Biomarkers for renal cell carcinoma

ABSTRACT

The present invention relates to methods for the screening, diagnosis and/or prognosis of renal cell carcinoma. The methods of the invention are based on the determination of expression profiles of sets of miRNAs representative for renal cell carcinoma optionally associated with genotype analysis, in particular of uromodulin SNP variants. The invention also refers to a kit to perform such methods.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a 371 of PCT/EP2020/051053, filed Jan. 16, 2020, which claims the benefit of European Patent Application No. 19152126.9, filed Jan. 16, 2019.

TECHNICAL FIELD

The present invention relates to methods for the screening, diagnosis and/or prognosis of renal cell carcinoma. In particular, the methods of the invention allow (i) to predict the presence of a renal mass; (ii) to predict if such renal mass is benign or malignant, (iii) to predict its aggressiveness status and the clinical severity of RCC (stage, grade, and metastasis); (iv) to monitor the progression or regression of RCC in a subject (eg in “watchful waiting” before treatment or surgery or during an oncological therapy to evaluate the effect of the treatment), (v) to monitor the occurrence of RCC in a subject at risk (obese patients, autosomal dominant polycystic kidney disease patients, diabetes, etc), (vi) to detect the recurrence of RCC (eg after partial nephrectomy in the remnant part of the operated kidney or after radical nephrectomy in the contralateral organ or after any type of surgery in other distant organs for metastatic patients), (vii) to distinguish RCC from other renal functional diseases or other malignant diseases (eg, infections, inflammatory or fibrotic systemic diseases or other aetiology of tumors which involve the kidney, eg sarcoma, urothelial cancer, etc).

The methods of the invention are based on the determination of expression profiles of sets of miRNAs representative for renal cell carcinoma compared to a reference and it may be associated with genotype analysis, in particular of uromodulin SNP variants. The invention also refers to a kit to perform such methods.

BACKGROUND ART

Renal Cell Carcinoma

Epidemiology Renal cell carcinoma (RCC) in adults comprehends a heterogeneous group of tumours which derive from renal tubular epithelial cells and represents the most common type of kidney cancer (80%) [Znaor et al., 2015; Chow et al., 2010; Siegel et al., 2017].

Every year more than 350,000 patients have a new diagnosis worldwide, which made it the seventh most common site for tumours [Pantucka et al., 2001]. This cancer is associated with more than 140,000 deaths per year; only in Europe, it was estimated an incidence of 84,400 new cases of RCC and 34,700 kidney cancer-related deaths [Siemer et al., 2006]. RCC has a male-female ratio of 2:17 and occurs most commonly in the fifth to sixth decade, with cancer-specific mortality extremely heterogeneous according to host characteristics [Thompson et al., 2008]. The incidence of RCC has increased since the 1980s by an average of 3% per year, largely related to incidental detection secondary to the more prevalent use of ultrasonography and CT scan [Adams et al., 2008]. The most generally accepted risk factor for RCC is cigarette smoking, although the relative associated risks have been modest, ranging from 1.4 to 2.5 compared with controls [Cumberbatch et al., 2016]. Other established risk factors for RCC include excess body weight and hypertension [Lipworth et al., 2006]. Medical conditions that have been associated with RCC in epidemiological studies include chronic kidney disease, haemodialysis, kidney transplantation, acquired kidney cystic disease, a previous RCC diagnosis and, possibly, diabetes mellitus [Dellavalle et al., 2013].

Histological Classification

Renal cell carcinoma (RCC) classification is based on cytogenetic, genetic and histological studies on both familiar and sporadic tumors [Pantucka et al., 2001]. According to the World Health Organization there are three major histological subtypes of RCC, all differentiated by histological and molecular genetic changes: clear cell (70-80%), papillary (10-15%) and chromophobe (4-5%). The remaining 10-15% of renal tumors include a variety of uncommon, sporadic, familiar carcinomas, and a group of unclassified carcinomas [Cumberbatch et al., 2016].

Among the minor histological subtypes there are oncocytoma and angiomyolipoma which represent renal tumours with a benign prognosis [Ljungberg B et al., 2016].

Clear cell renal cell carcinoma (ccRCC) represents the most common type of RCC. Most ccRCC are composed predominantly of cells containing clear cytoplasm, although eosinophilic cytoplasm predominates in some cells. The growth pattern may be solid, tubular and cystic. Grossly, ccRCC is well circumscribed, capsule is usually absent [D′Avella C et al., 2018]. The cut surface is golden-yellow, often with haemorrhage and necrosis. The indolent variant of ccRCC is multilocular cystic and accounts for approximately 4% of all ccRCC. Up to 95% of ccRCC are sporadic. The most common genetic alteration reported is loss of sequence in the short arm of chromosome 3 [Bex a et al., 2018]. This happens because of a deletion (3p-) or because of a chromosomic translocation (3;6, 3;8, 3;11) that results in the loss of chromosome 3 sequences from 3p12 to 3p26. This is the region where VHL gene is located (3p25.3). Other associated molecular changes may be duplication of the chromosome band 5q22, deletion of chromosome 6q, 8p, 9p and 14q. Sequencing studies have identified other driver genes that are involved in the pathogenesis of renal cell carcinoma, including PBRM1, BAP1, SETD2, TCEB1 and KDM5C32,33. Studies analyzing the effects of these mutations on clinical outcomes, however, are limited by small sample sizes, short-term follow-up, and lack of assessment of multiple markers in the same cohort [Lalani A A, et al., 2018].

Papillary renal cell carcinoma (pRCC) comprehends up to 10-15% of all renal cell carcinomas. Macroscopically, pRCC is well circumscribed with pseudocapsule, yellow or brown in color, and a soft structure. Its growth pattern is typically papillary and it can arise both in a sporadic or familiar way. Pseudocapsules and extensive necrotic changes cause a spherical tumor in the extra renal section [BhindiB et al., 2018]. Tumors with massive necrosis are fragile and vulnerable to spontaneous rupture or rupture resulting from minimal trauma followed by retroperitoneal bleeding. Necrosis cohere with a hypodense central area of tumor on postcontrast CT. This area is surrounded by a vital tumor tissue, seen as a serpiginous contrast-enhancing margin on CT. Papillary renal cell carcinoma is not associated with deletion of chromosome 3p. The most common cytogenetic abnormalities found are trisomies of chromosomes 3q, 7, 8, 12, 16, 17, the loss of Y chromosome in men within the sporadic form and the trisomy of chromosome 7 within the familiar one. Trisomy of chromosome 7, which contains both MET and HGF/SF genes, occurs in 95% of sporadic papillary renal carcinoma. Unlike clear cell RCC, papillary RCC is frequently multifocal from its origin [Wagener N et al., 2018]. Papillary RCCs can be divided into type 1 and type 2 lesions based upon histopathologic features. Type 1 and type 2 papillary carcinomas differ in both clinical features and in their underlying genetic abnormalities:

-   -   Type 1 papillary RCC (p1RCC): p1RCC typically presents with         stage I or II disease, and these patients have a relatively         favourable prognosis. Although type 1 lesions usually occur in         patients with hereditary papillary RCC, most these reports are         sporadic. In the hereditary form this disease, activating         germline mutations are seen in MET. In non-hereditary forms of         the disease, somatic mutations in MET have been identified in         approximately 10 to 20 percent of cases. Type 1 tumors are         papillary lesions covered by small cells with pale cytoplasm and         small oval nuclei with indistinct nucleoli [Pal S K et al.,         2018].     -   Type 2 papillary RCC (p2RCC): p2RCC is frequently associated         with aggressive tumors that are stage III or IV at presentation         and are associated with a poor prognosis. These tumors have also         been seen in the hereditary leiomyomatosis and renal cell cancer         syndrome, which is caused by germline mutation in the gene for         fumarate hydratase (FH). Very few patients had alterations in         the MET pathway. Type 2 tumors are papillary lesions covered by         large cells with abundant eosinophilic cytoplasm. Type 2 cells         are typified by pseudo stratification and large, spherical         nuclei with distinct nucleoli [Pal S K et al., 2018].

Chromophobe (chRCC): The chromophobe variant of renal cell carcinoma also accounts for 4 percent of all cases of renal cell carcinoma and may have a benign course after surgery, provided that the tumor stage and grade are favorable. The cells of chRCC may have pail or eosinophilic granular cytoplasm. Growth usually occurs in solid sheets. The genetic characteristic of chromophobe RCC is a combination of loss of chromosomes 1, 2, 6, 10, 13 and 17. It is thought to arise from type B intercalated cells of the collecting ducts [Leibovich B C et al, 2018]. Oncocytoma: Oncocytomas, which are benign, account for about 4 percent of nephrectomies performed because renal cell carcinoma is suspected. Oncocytoma is thought to originate from type A intercalated cells of the collecting duct [Valdes Olmos R A et al., 2016].

Diagnosis

The major clinical obstacles in RCC diagnosis and therapy are the unspecific symptoms and the absence of predictive biomarkers for RCC [Heidenreich et al., 2004]. In many cases, RCC remains clinically silent, as the simultaneous presence of haematuria, pain and palpable mass at the side, considered the classic presentation triad, is actually very rare (1%) [Ljungberg et al., 2014]. Symptoms of systemic disease, such as persistent cough, bone pain, cervical lymphadenopathy, constitutional symptoms, weight loss, fever, malaise, lead to a diagnosis in up to 30% of metastatic patients [Hollingsworth et al., 2007].

Historically, survival outcomes for patients with advanced disease have been poor even with oncological treatment. On the contrary, if renal cancer is detected at early stages, surgical treatment remains the unique resolutive therapy with a free survival from metastatic disease around 95% in five years. [Hollingsworth et al., 2007].

RCC is detected mostly by abdominal ultrasound scanning by chance in day to day clinical practice; however, due to its limitations in specificity and accuracy, only CT scan and MRI technologies represent the gold standard tools for renal masses identification [Kutikov et al., 2009]. Unfortunately, both techniques are still unable to distinguish the presence of a benign lesion (e.g. oncocytoma and fat-free angiomyolipoma) from a malignant one (RCC) and this misleading error leads every year up to 20% of unnecessary surgical operations [Linehan et al., 2007]. Percutaneous renal tumor biopsies are increasingly being used for histological diagnosis when the radiological exams are confused and not able to identify clearly a malignant neoplasm; however, due to RCC heterogenicity, renal biopsies do not determine the aggressiveness of cancer [Richard et al., 2015].

Therefore, there is still the need for clinical and molecular strategies capable of stratifying the population according to the risk of developing RCC.

Staging and Grading

RCC tends to spread either by direct invasion through the renal capsule into perinephric fat and adjacent visceral structures or by direct extension into the renal vein. The most common site of distant metastases is the lung [Taneja K et al., 2018] However, liver, bone, adrenal gland, brain, the contralateral kidney and the subcutaneous tissue are potential sites of disease spread. The current International Union Against Cancer (UICC) 2017 TNM (Tumour Node Metastasis) classification is recommended for the staging of RCC (Table 1), where stages I-II represent low risk tumours whereas stages III-IV are high risk neoplasm with a considerable metastatic power dissemination [Brookman-May S D et al., 2015].

TABLE 1 TNM classification system (2017). T - Primary tumor TX Primary tumor cannot be assessed T0 No evidence of primary tumor T1 Tumor <7 cm in greatest dimension, limited to the kidney T1a Tumor ≤4 cm in greatest dimension, limited to the kidney T1b Tumor >4 cm but ≤7 cm in greatest dimension T2 Tumor >7 cm in greatest dimension, limited to the kidney T2a Tumor >7 cm but ≤10 cm in greatest dimension, limited to the kidney T2b Tumors >10 cm, limited to the kidney T3 Tumor extends into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and not beyond Gerota's fascia T3a Tumor extends into the renal vein or its segmental branches, or invades the pelvicalyceal system, or invades perirenal and/or renal sinus fat but not beyond Gerota's fascia T3b Tumor extends into the vena cava below the diaphragm T3c Tumor extends into the vena cava above the diaphragm or invades the wall of the vena cava T4 Tumor invades beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland) N - Regional lymph nodes NX Regional lymph nodes cannot be assessed N0 No regional lymph node metastasis N1 Metastasis in regional lymph node(s) M - Distant metastasis M0 No distant metastasis M1 Distant metastasis TNM stage grouping Stage I T1 N0 M0 Stage II T2 N0 M0 Stage III T1, T2 N1 M0 T3 Any N M0 Stage IV T4 Any N M0 Any T Any N M1

The Fuhrman system was the most frequently used grading system in RCC but should not be applied for chromophobe RCC [Zhang G et al., 2018]. Furthermore, the Fuhrman system has not been validated for most of the new subtypes of renal carcinoma. For these reasons, the four-tiered WHO/ISUP grading system is recommended by the WHO. For grade 1-3 tumours, the system defines tumour grade based on nucleolar prominence. Grade 4 is defined by the presence of pronounced nuclear pleomorphism, tumour giant cells, and/or rhabdoid and/or sarcomatoid differentiation [Nini et al., 2018]. This grading system has been validated for ccRCC and papillary RCC. It has not yet been validated for other tumour types because of the small numbers of reported cases.

Treatment Surgery remains the basis of the curative treatment, despite advances in understanding the biology of RCC. Historically radical nephrectomy was the standard of care for management of renal tumours but the developing of chronic kidney disease and hypertension after the acute nephron mass loss in several patients have led to a more conservative approach with nephron sparing technique [Capitanio et al., 2015].

Uromodulin

Tamm-Horsfall protein was discovered by Igor Tamm and Frank Horsfall in 1950 when they precipitated a protein from the urine that inhibited hemagglutination of viruses [Pennica et al., 1987]. This glycoprotein is exclusively expressed in the kidney, specifically by cells lining the thick ascending limb of the nephron [Muchmore et al., 1985]. The domain composition of uromodulin includes a leader peptide directing its entry in the secretory pathway, four epidermal growth factor (EGF)-like domains (EGF-II and EGF-III predicted to be calcium binding), a central domain of unknown function (named D8C as it contains eight conserved cysteines), a zona pellucida domain, and a glycosylphosphatidylinositol-anchoring site [Rampoldi et al., 2012].

Given its abundance, unique structure and evolutionary conservation through all vertebrate species, a number of physiological and pathological roles have been hypothesized for uromodulin [Bachmann et al., 1985]. These include its role in defence against urinary tract infection, prevention of kidney stone formation, modulation of salt and water retention, hypertension, and more recently its possible role in inflammation and immunomodulation during acute kidney injury as well as in the pathogenesis of CKD [El-achkar et al., 2012]. The potential link between uromodulin and kidney function has been emphasized by some innovative studies that investigated for the first time the role of UMOD variants in regulating UMOD excretion in urine and the possibility that this could affect tubular function and progressive chronic kidney disease [Rampoldi et al., 2003]. Later, several genome-wide association studies revealed that variants in the UMOD gene are strongly associated with markers of renal function and risk of developing CKD in the general population [Bleyer et al., 2010; Trudu et al., 2014]. The biological role of uromodulin in the background of renal cancer occurrence, onset and development has not been clarified yet. The first studies in this field demonstrated the presence of uromodulin in samples of renal cell carcinomas [Kottgen et al., 2010]. Recently, there has been a growing interest in applying proteomics approaches in research on clinical diagnostics and predictive medicine, and uromodulin was one of the investigated proteins in the context of renal cell carcinoma [Eikrem et al., 2016]. The main proteomic goals are to detect quantitative and qualitative differences between normal and pathological samples and to identify these differentially expressed proteins [Eikrem et al., 2016]. The possible role of uromodulin as a specific biomarker of RCC in biological fluids such as urine remains uncertain and demands further investigation.

Micro RNAs

In biology, miRNAs are epigenetic regulators of gene expression able to modulate several cellular processes, from development to disease condition [Krol et al., 2010]. The process of epigenetic regulation is accomplished through binding of miRNAs to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization [Lim et al., 2005]. The human miRNAome is composed of 1,881 precursors and 2,588 mature miRNAs, which regulate at least 60% of protein-coding genes [Bracken et al., 2016]. Because of their broader targeting characteristics, miRNAs are expected to be involved in most biological pathways and cellular processes including cell proliferation, apoptosis, cellular development and cellular signalling [Zhu et al., 2016]. Since 2010, the number of miRNAs included in miRBase has grown by approximately two-thirds owing to the advent of small RNA deep sequencing techniques[Lorenzen et al., 2012].

The majority of miRNAs are located within the tissue's cell, but some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media [Trevisani et al., 2016]. Transcription of miRNAs occurs from individual or clustered genes, although some miRNAs can be encoded from distinct genomic loci. Genes encoding miRNAs are located in non-coding sequences or in introns of either protein-coding genes (miRtrons) or non-coding RNA [Lytle et al., 2007]. Intronic miRNAs are usually co-ordinately expressed with their host gene and most of the time they both affect the same signalling pathway [Baek, D. et al, 2008]. RNA polymerase II transcribes miRNAs in the nucleus as long capped and polyadenylated hairpin transcripts, called primary miRNAs (pri-miRNAs) [Eichhorn et al., 2004]. These are processed into smaller ^(˜)70 nucleotide stem-looped structures, called precursor miRNAs (pre-miRNAs) by the ribonuclease III-like enzyme Drosha together with the microprocessor complex subunit DGCR8. Pre-miRNAs are then exported to the cytoplasm by exportin-5/GTP-binding nuclear protein Ran, where the ribonuclease Dicer yields 22 nucleotide miRNA duplexes consisting of the guide and passenger strands [Acunzo et al., 2015]. The guide strands are finally assembled into the RNA-induced silencing complex (RISC) and bind through their ‘seed sequence’ (nucleotides 2-8) to fully or partially complementary sites within the 3′ untranslated region of target mRNAs [Yamaguchi et al., 2017].

MiRNAs also have a key role as regulators of cellular crosstalk. They can be actively secreted into the extracellular microenvironment or into body fluids and captured by other cells, thus altering their transcriptional programme [Lampis et al., 2018]. In addition, circulating miRNAs can be derived from apoptotic cells, with the likely purpose of carrying alarm signals from apoptotic cells to other cells [Calin et al., 2004]. miRNAs circulate in blood, urine and other body fluids either packaged into microvesicles and/or exosomes or transported by RNA binding proteins (Argonaute2 complexes) and lipoproteins, which protect them from degradation by ribonucleases [Trionfini et al., 2015]. Given their ease of access, abundance, and stability, circulating miRNAs are novel promising minimally-invasive biomarkers for diagnosis and prognosis of plenty kinds of diseases, such as cancer [Mitchell et al., 2008]. Indeed, there is increasing evidence that miRNAs are involved in oncogenesis and tumour progression [Iorio et al., 2012]. In addition, miRNA signatures in blood are similar in men and women, and independent of patients' age [Mooney et al., 2015; Hunter et al., 2008]. Specific expression profiles of miRNAs have been shown in a variety of cancers, including RCC [Weng et al., 2010; Schaefer et al., 2010]. More importantly, miRNAs are thought to be excellent biomarkers not only for the diagnosis, but also for the prognosis and the classification of cancer [Schaefer et al., 2010]. Differences in the miRNA profiles of tumours versus adjacent renal tissues have been extensively explored [Tang et al., 2015; Li et al., 2015]. However, not always miRNAs deregulated in tissue are also deregulated in blood and vice versa [Keller et al., 2011]. Recently, few studies have assessed circulating levels of miRNA in the blood of RCC patients, but no consistent circulating miRNA signatures of renal cancer have emerged. Authors have often used a candidate miRNA approaches for their investigations [Zhao et al., 2013; Zhang et al., 2013; Zhai et al., 2012; Iwamoto et al., 2014; Hauser et al., 2012; Fedorko et al., 2015; Teixeira et al., 2014] and in the four genome-wide studies performed to date there was no obvious overlap between the miRNA expression profiles obtained [Chanud et et al., 2017; Wulfken et al., 2011; Redova et al., 2012; Wang et al., 2015]. Variability in plasma/serum expression levels of miRNAs in different works could be due to several critical factors: sample collection and processing (es. serum samples could present an altered miRNAs composition due to the coagulation process [Wang et al., 2012]), RNA extraction, and normalization methods. In addition, in three out of four of the genome-wide studies mentioned before, screening was limited to small numbers of samples (6, 15 and 25 RCC patients respectively) [Wulfken et al., 2011; Redova et al., 2012; Wang et al., 2015].

Consequently, lager and deeper research are needed in the novel field of circulating miRNAs in renal cancer.

SUMMARY OF THE INVENTION

In the present invention, the inventors surprisingly found an association of UMOD SNP variants with renal mass presence, malignancy, and aggressiveness in patients. Further specific plasma-circulating miRNAs were found to discriminate renal cancer patients from controls, to discriminate patients with a malignant lesion from those with a benign mass, to determine aggressiveness of RCC.

UMOD genotype may be combined with miRNA profile and optionally together with clinical parameters to provide a screening test and to improve the accuracy and specificity of diagnosis, prognosis, and classification of renal cancer.

In particular, the methods of the invention allow (i) to predict the presence of a renal mass; (ii) to predict if such renal mass is benign or malignant, (iii) to predict its aggressiveness status and the clinical severity of RCC (stage, grade, and metastasis); (iv) to monitor the progression or regression of RCC in a subject (eg in “watchful waiting” before treatment or surgery or during an oncological therapy to evaluate the effect of the treatment), (v) to monitor the occurrence of RCC in a subject at risk (obese patients, autosomal dominant polycystic kidney disease patients, diabetes, etc), (vi) to detect the recurrence of RCC (eg after partial nephrectomy in the remnant part of the operated kidney or after radical nephrectomy in the contralateral organ or after any type of surgery in other distant organs for metastatic patients), (vii) to distinguish RCC from other renal functional diseases or other malignant diseases (eg, infections, inflammatory or fibrotic systemic diseases or other aetiology of tumors which involve the kidney, eg sarcoma, urothelial cancer, etc).

Therefore the invention provides a method to determine if a renal mass present in a subject is a benign or a malignant renal mass or a method to predict if a renal mass present in a subject is a renal cell carcinoma (RCC) or a method to detect the recurrence of a renal mass or a method to identify if a subject is affected by RCC or by other renal functional diseases (diseases that affects the renal parenchyma as a result of a systemic pathological process) or by other malignant diseases (other types of tumours that affect kidneys except RCC) said method comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 11 or Table 21 or is selected from the group consisting of: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p and wherein said combination is indicated in Table 16 or Table 25.

Preferably the method according further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs11647727, rs28640218, rs7193058, rs76563024, rs11862974, rs13329952, rs7203642, rs7204342, and rs28688991 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs are selected from the group consisting of: rs7204775, rs4997081, rs12922822, rs12917707, rs9933330, rs13334589, rs13333226, rs28362063, rs4293393, rs35650857, rs34882080, rs13335818, rs28544423, rs9928003, rs12934320, rs34356953, rs34115067, rs60136849, rs9928936, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71149135, rs71377648, rs80159442, rs11342813, rs6497476, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs74842838, rs143657120, rs145915865, rs75645968, rs114333799, rs114112267, rs75459600, rs76625281, rs76236484, rs4500734, rs58351658, rs4490010, rs147846395, rs34857077, rs6497475, rs7204210, rs6497474, rs8060932, rs8062123, and rs4238595.

The invention also provides a method to discriminate a subject affected by a low stage RCC from a subject affected by a high stage RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one is indicated in Table 13 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p and wherein said combination is indicated in Table 17 or Table 26.

Preferably said method further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs11647727, rs34356953, rs12934320, rs12934455, rs28640218, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs is selected from the group consisting of: rs12922822, rs9933330, rs13334589, rs34115067, rs9928936, rs71149134, rs7204775, rs71377648, rs9924088, rs9923990, rs9926225, rs111483946, rs112166439, rs113923200, rs554722277, rs111992415, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs8060932, rs8062123, rs4238595, rs7193058, rs34857077, rs6497475, rs6497474, rs181820305, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, and rs372456426.

The invention also provides a method to discriminate a subject affected by a low grade RCC from a subject affected by a high grade RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 22 or is selected from the group consisting of: hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 18 or Table 27.

Preferably said method further comprises determining the genotype of UMOD SNP rs13333226 or of any other UMOD SNPs in linkage disequilibrium with rs13333226 (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNP is selected from the group consisting of: rs7204775, rs7203642, rs4293393, rs4997081, rs28688991, rs28640218, rs13329952, rs13335818, rs34115067, rs60136849, rs9928936, rs35650857, rs34882080, rs71149135, rs34356953, rs11862974, rs6497476, rs11342813, rs7204342, rs76563024, rs80159442, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs28362063, rs13334589, rs9933330, rs12922822, rs12917707, rs28544423, rs9928003, rs12934320, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71377648, rs9928757, and rs71384446.

The invention also provides a method to determine the presence of clinical metastasis in a RCC patient comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 14 or is selected from the group consisting of: hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, and wherein the combination is indicated in Table 19.

Preferably said method further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs34356953, rs12934320, rs12934455, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs12922822, rs9933330, rs13334589, rs35650857, rs34882080, rs9928003, rs34115067, rs9928936, rs36060036, rs71149135, rs71149134, rs34262842, rs35830321, rs7204775, rs4997081, rs28640218, rs71377648, rs9924088, rs9923990, rs9926225, rs369494277, rs111483946, rs112166439, rs188045848, rs111904030, rs113923200, rs149786037, rs554722277, rs113452476, rs111992415, rs377257136, rs114997829, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs372456426, rs6497475, rs34857077, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, rs181820305, rs4238595, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs8060932, and rs8062123.

The invention also provides a method for the prognosis of RCC or a method to monitor the effect of a therapy on RCC in a subject comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 13 or Table 14 or Table 22 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, and hsa-miR-15a-5p, hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-3613-3p, hsa-miR-5481, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 17 or Table 18 or Table 19 or Table 26 or Table 27.

Preferably, said method further comprises determining the genotype of UMOD SNPs rs11647727, rs12917707, rs12934320, rs12934455, rs13329952, rs13333226, rs13335818, rs28362063, rs28544423, rs28640218, rs28688991, rs34356953, rs4293393, rs60136849, rs71384446, rs7203642, rs9928757 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs111266260, rs111483946, rs111904030, rs111992415, rs112166439, rs11342813, rs113452476, rs113923200, rs113957052, rs114997829, rs116563128, rs117774819, rs118059635, rs11862974, rs12102292, rs12922822, rs13334589, rs138755971, rs145279202, rs147946789, rs149233634, rs149786037, rs150044343, rs150052437, rs181711435, rs181820305, rs182188833, rs182605229, rs182744661, rs183590048, rs184483102, rs185128245, rs185578691, rs185630961, rs186260541, rs187620954, rs188045848, rs189908977, rs190450490, rs191065984, rs191171015, rs192180621, rs192280820, rs34115067, rs34262842, rs34857077, rs34882080, rs35650857, rs35830321, rs36060036, rs369494277, rs372456426, rs377257136, rs4238595, rs4997081, rs528859496, rs544951514, rs554722277, rs55808501, rs58768874, rs59027126, rs6497474, rs6497475, rs6497476, rs71149134, rs71149135, rs71377648, rs7193058, rs7204342, rs7204775, rs74011921, rs74011925, rs75864273, rs76563024, rs77225526, rs77875418, rs78052469, rs79245268, rs80142672, rs80159442, rs8060932, rs8062123, rs9923990, rs9924088, rs9926225, rs9928003, rs9928936, rs9933330, rs9937393.

The invention also provides a method to predict the presence of a renal mass in a subject comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 10 or Table 20 or is selected from the group consisting of: hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-28-3p, hsa-miR-15b, 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, and hsa-miR-494-3p and wherein the combination is indicated in Table 15 or Table 24.

Preferably in any of herein disclosed methods the subject is affected by obesity, autosomal polycystic kidney disease, multicystic kidney disease, hypertension or diabetes or wherein the subject is a smoker or has a family history of kidney cancer

In a still preferred embodiment any of disclosed herein method further comprises measuring the level of uromodulin in a biological sample of the subject and comparing said measured level to a reference level, preferably the biological sample is selected from the group consisting of: plasma, serum and urine sample.

In a still preferred embodiment any of disclosed herein method further comprises the analysis of a phenotypic characteristic, preferably selected from the group consisting of:

-   -   clinical parameters, such as age at diagnosis/treatment,         comorbidity index and specific comorbidities or history of         previous renal or non-renal cancer;     -   radiological parameters, such as clinical size defined as         clinical diameter at axial imaging, tumor volume, clinical tumor         stage, clinical nodal stage, PADUA score, RENAL score, ABC score         or other nephrometric scores;     -   biohumoral parameters, such as hemoglobin, platelets,         creatinine, urea, blood electrolytes, total protein serum level         and electrophoresis, measured and estimated glomerular         filtration rate, proteinuria and urine tests.

In a still preferred embodiment, any of disclosed herein method the biological sample is selected from: blood, blood cells, serum, plasma, urine, saliva, sputum, tears, kidney tissue.

The present invention also provides a kit for use in a method according to any one of previous claim comprising means to quantify said miRNA and control means and optionally comprising means to determine at least one UMOD genotype, preferably said kit comprises an array. Clinical metastasis is revealed by the most common and standard radiological imaging tests (CT, MRI) and is detected before surgery (e.g. renal tumor mass) or after diagnosis of renal tumor. In the present invention the reference level to which the measured miRNA is to be compared with is the value measured in a biological sample of a healthy subject, or the value measured in a biological sample of a subject that does not have a renal mass and/or any previous history of any type of cancer (non-renal mass control). It can also be the value measured in a biological sample of a subject without a renal mass, the value measured in a biological sample of a subject with oncocytoma or other benign renal mass, the value measured in a biological sample of a subject with RCC, the value measured in a biological sample of a subject with low or high grade RCC, the value measured in a biological sample of a subject with low stage or high stage RCC, the value measured in a biological sample of a subject with or without clinical metastasis, the value measured in a biological sample of a subject with RCC before starting a therapy or throughout the course of therapy treatment, the value measured in a biological sample of a subject with RCC in active surveillance, the value measured in a biological sample of a subject with a previous surgery for RCC. The skilled person will choose the appropriate reference value according to the comparison to be made.

Indicated miRNA can be found in the miRbase Version v22.

In the methods of the present invention, the nucleotide sequences of said miRNAs can be found in the miRbase Version v22 and are selected from the group consisting of (i) a nucleotide sequence according to the miRbase Version v22, (ii) a nucleotide sequence that is a fragment of the nucleotide sequence according to (i), preferably, a nucleotide sequence that is a fragment which is between 1 and 12, more preferably between 1 and 8, and most preferably between 1 and 5 or 1 and 3, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, nucleotides shorter than the nucleotide sequence according to (i), and (iii) a nucleotide sequence that has at least 80%, preferably at least 85%, more preferably at least 90%, and most preferably at least 95% or 99%, i.e. 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99%, sequence identity to the nucleotide sequence according to (i) or nucleotide sequence fragment according to (ii).

MiRNAs of the present invention may be detected and quantify according to any method known in the art, including methods disclosed herein.

In some aspects, the miRNAs of the present invention are upregulated or overexpressed in renal cell carcinoma or depending on the stage/grade of the carcinoma, the presence or not of clinical metastasis, as well as the histotype of renal mass; In some aspects, the miRNAs of the present invention are downregulated or under-expressed in renal cell carcinoma or depending on the stage/grade of the carcinoma, the presence or not of clinical metastasis, as well as the histotype of renal mass.

The present invention also provides miRNA signatures or “expression signatures”, as indicated in herein tables.

An “expression signature” is a group of two or more genes or gene-related molecules (e.g., DNA, RNA, amino acids and proteins) that exist in a cell, tissue fluid or other sample whose combined expression pattern is characteristic of a particular tissue or is characteristic of a particular condition, or disease state. The expression signature can be used to select or stratify a group of subjects based on, for example, a specific stage of a disease, a risk of developing a particular disease or state of disease or a probability or prediction of a prognosis, with sufficient accuracy to facilitate diagnosis or selection of treatment.

MiRNA is a group of small non-coding RNAs that regulate gene expression during development and differentiation (Bartel 2004). miRNA expression is very tissue-specific (Bartel 2004). Some miRNAs that are stably expressed in certain tissue types might be expressed differently in other tissue types. In some embodiments, the miRNA molecules are present in tissues and/or organs at normal physiological conditions but may be expressed at a much higher or lower level in diseased tissue or cells and are indicative of a change in health status. In other embodiments, the biomarkers may be absent in tissues and/or organs under normal physiological conditions but are specifically expressed in diseased tissue or cells. In other embodiments, the biomarkers may be specifically released to the bloodstream under conditions of RCC, and/or are over- or under-expressed as compared to normal levels. Measurement of miRNA, alone or in combination, in patient samples provides information that may correlate with a diagnosis of the selected disease. Therefore, a set of one or more miRNA molecules may be used in screening, diagnostic and prognostic assays.

As used herein the phrase “diagnostic” or means identifying the presence or nature of a pathologic condition. Diagnostic methods differ in their sensitivity and specificity. The “sensitivity” of a diagnostic assay is the percentage of diseased individuals who test positive (percent of “true positives”). Diseased individuals not detected by the assay are “false negatives.” Subjects who are not diseased and who test negative in the assay may be termed “true negatives.” The “specificity” of a diagnostic assay is 1 minus the false positive rate, where the “false positive” rate is defined as the proportion of those without the disease who test positive. While a particular diagnostic method may not provide a definitive diagnosis of a condition, it suffices if the method provides a positive indication that aids in diagnosis. As used herein the phrase “diagnosing” refers to classifying a disease or a symptom, determining a severity of the disease, monitoring disease progression, forecasting an outcome of a disease and/or prospects of recovery. The term “detecting” may also optionally encompass any of the above.

A “prognosis” may be measured as any outcome of illness. In some embodiments a prognosis is a measurement of or prediction of overall survival, recurrence-free survival, or progression of a disease. A good prognosis indicates, for example, that the disease is less likely to progress, the chance of survival after diagnosis or treatment is high or the length of time a subject is likely to live after diagnosis or after treatment is a relatively long period of time. A poor prognosis indicates, for example, that the disease is more likely to progress, the chance of survival after diagnosis or treatment is low or the length of time a subject is likely to live after diagnosis or after treatment is relatively short.

Alteration of miRNA expression has been shown in malignancies (Michael et al. 2003; Calin et al. 2005; Yanaihara et al. 2006) and plays an important role in tumorigenesis and cancer progression (Esquela-Kerscher & Slack 2006). Studies have shown that certain miRNAs play important roles in various steps of the metastatic cascade, such as the endothelial-mesenchymal transition (EMT), adhesion, migration, invasion, apoptosis and angiogenesis. Because the expression of multiple genes can be regulated by a single miRNA, miRNA expression profiles may be more accurate in determining cancer subtypes than RNA profiles of protein-coding genes (Calin& Croce 2006; Volinia et al. 2006). Expression signatures based on miRNA expression have been shown to aid in diagnosis and prognostication of cancer (Yu et al. 2008; Hiroki et al. 2010).

In the current study, miRNA expression levels in patients affected by a renal mass or RCC were profiled. MiRNA expression levels be profiled using a microarrays or PCR-based assay, as further discussed herein.

miRNA expression may be detected by any suitable method for RNA detection including, but not limited to, microarray, reverse transcriptase polymerase chain reaction (RT-PCR) or other PCR-based assays (e.g. quantitative or real time RT-PCR) or mass spectrometry.

A method for generating a miRNA expression signature may comprises performing a logistic regression analysis to identify a set of one or more miRNAs associated with presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or a specific kidney cancer histotype.

A method for generating a miRNA expression signature may also include a step assigning a risk score to each patient with a renal mass by calculating a risk score formula and determining a cut-off risk score to stratify the cohort subjects into one or more risk groups (e.g., high risk, low risk, intermediate risk) as described in further detail in the examples below.

In other embodiments, methods for predicting a presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or a specific kidney cancer histotype, hence aiding clinical decision making in the screening, diagnosis and prognostication of the disease, are provided. These methods may include detecting a test expression level of one or more miRNAs as part of a cancer-specific expression signature in a biological sample from a subject having a cancer, assigning a risk score to the test expression level; and predicting a presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or specific kidney cancer histotype, hence aiding clinical decision making in the screening, diagnosis and prognostication of the disease.

When the test expression level is assigned a high-risk score, the subject is likely to have kidney cancer, presence of adverse phenotypic kidney cancer characteristics. When the test expression level is assigned a low risk score, the subject is not likely to have kidney cancer, presence of adverse phenotypic kidney cancer characteristics.

In some embodiments, the methods of the present invention provide for utilizing a biological sample of a subject or patient received from a third party; or obtaining a biological sample from a subject or a patient. Examples of suitable biological samples which may optionally be used with the embodiments of the present invention include but are not limited to blood, serum, plasma, blood cells, urine, sputum, saliva, stool, spinal fluid or CSF, lymph fluid, the external secretions of the skin, respiratory, intestinal, and genitourinary tracts, tears, milk, neuronal tissue, lung tissue, any human organ or tissue, including any tumor or normal tissue, any sample obtained by lavage (for example of the bronchial system or of the breast ductal system), and also samples of in vivo cell culture constituents. The sample can optionally be diluted with a suitable eluant before contacting the sample to an antibody and/or performing any other diagnostic assay.

Numerous well-known tissues or fluid collection methods can be utilized to collect a biological sample from the subject in order to genotype and/or sequence DNA regions, determine the level of RNA and/or polypeptide of the variant of interest in the subject. Examples include, but are not limited to, liquid biopsy, fine needle biopsy, needle biopsy, core needle biopsy and surgical biopsy (e.g., brain biopsy), and lavage. Regardless of the procedure employed or where the biopsy or sample is obtained, the level of the variant can be determined, and a diagnosis can thus be made.

The present invention will be illustrated by means of non-limiting examples in reference to the following figures.

FIG. 1 . Pairwise r² values among the 22 UMOD SNPs genotyped in this study.

Linkage disequilibrium (LD) map for the 22 UMOD SNPs genotyped in this study. Variants are ordered by chromosomal position. A pairwise r² value is shown in each square. Darker blocks correspond to higher r² values. LD r² values were from 1000 Genomes Phase 3 genotypes for the Tuscan population (TSI, Toscani in Italy).

FIG. 2 . Schematic representation of human UMOD gene structure. The position of the 22 UMOD SNP variants is shown.

DETAILED DESCRIPTION OF THE INVENTION

Patients

The study population consisted of 276 patients with a diagnosis of a first episode of renal mass, elected for surgical treatment via nephron sparing surgery or radical nephrectomy, together to 83 non renal mass controls consisted of patients affected by urological functional diseases (kidney stones, benign prostate hypertrophy, etc).

This total cohort of patients was included in the analysis of UMOD genotypes. A subgroup of 120 cases (patients affected by renal masses) together to 78 controls (patients affected by urological benign disfunctions) were included in the analysis of circulating miRNAs. This cohort of patients was composed by a retrospective monocentric phase together with a prospective European multicentric phase.

The prospective cohort was formed by 110 patients (59 case and 51 controls). It is important to underline that each control patient was submitted to an abdominal CT scan to exclude the concomitant presence of a renal mass.

A retrospective cohort refers to patients whose biological samples have been already collected and stored in a biobank and clinical data have been reported in a dataset.

A prospective cohort refers to patients, which are followed over time, whose biological samples and clinical data are collected.

The study population was enrolled from 2011 to 2018 in a single tertiary care institution. From 2019, in addition to this center, other four European centers were involved into the prospectively maintained dataset and specimen collection.

Study Outcomes

The aim of the study was to identify novel biomarkers that can improve the management of patients with RCC at all the stages of clinical decision-making, in particular in 3 specific clinical settings:

1. Screening

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the presence of a renal mass, defined as a mass either benign or malignant recorded at axial imaging examination (either CT or MRI). In the model, the inventors compared the above-mentioned markers in patients diagnosed with a renal mass relative to controls. The clinical implication of this information is the identification of patients with high risk of a renal mass to axial imaging.

2. Diagnosis of Kidney Cancer

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the presence of RCC, defined as a renal malignancy. In the model, the inventors compared the above-mentioned markers in patients diagnosed with any RCC histological subtype (ccRCC, p1RCC, p2RCC, chRCC) relative to patients diagnosed with a benign renal mass (oncocytoma, angymyolipoma, benign cyst or other benign histotype). The clinical implication of this information is the selection or identification of patients with high risk of RCC and of patients with low risk of RCC to be inserted in specific treatment or surveillance protocol.

3. Prognostic

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the prognosis of patients diagnosed with aggressive RCC. Inventors relied on established predictors of RCC prognosis that are direct markers of clinical aggressiveness, namely

-   -   a. tumour stage, defined using the AJCC 2018 staging system and         grouped as pT1-pT2 (low stage) vs pT3-pT4 (high stage) [Edge et         al., 2010];     -   b. pathologic N stage, defined using the AJCC 2018 staging         system and grouped as pN0-pNx vs pN1 [Edge et al., 2010];     -   c. tumour grade, defined according to the Furhman classification         system or WHO/ISUP and grouped as G1-G2 (low grade) vs G3-G4         (high grade) [Delahunt et al., 2013—Delahunt et al., 2016];     -   d. presence of clinical metastasis, defined as cM1 stage at         systemic clinical staging [Edge et al., 2010].

The clinical implication of this information is the identification of patients with high risk of aggressive RCC for specific treatment. The model allows to spare an aggressive treatment in older and more frail patients. Moreover, the model allows the identification of patients that could benefit from post-treatment follow-up based on the aggressiveness of the disease.

Study Population

The study population consisted of 276 patients with a diagnosis of a first episode of renal mass, elected for surgical treatment via nephron sparing surgery or radical nephrectomy, together to 83 non renal mass controls consisted of patients affected by urological functional diseases (kidney stones, benign prostate hypertrophy, etc).

Among those with a renal mass, the median age was 64 years old with a male predominance on female patients (65.6% vs 34.4%) as reported in literature. In the final pathology evaluation, the 16.3% of patients demonstrated a benign lesion whereas the 83.7% a malignant one. High stage (pT3-pT4) was diagnosed in the 36.4% while low stage (pT1-pT2) was reported in the 63.6%: in the 59.7% the population displayed low grade tumors (G1-G2) while 40.3% high grade neoplasms (G3-G4). The discrepancy (patients with T1 or T2 staging but G3 or G4 grading and vice versa) between TNM staging and Furman/WHO-ISUP grading was about 24.3%. The 12.3% of patients was affected by a metastatic process.

In the controls group, median age was 58 years old, with a male-female percentage of 62.7% and 37.3%, respectively (Table 2).

TABLE 2 Descriptive analysis of UMOD genotypes total cohort of patients Renal mass patients Controls Number of patients, n 276 83 Age, median (range)  64 (55-72) 58 (50-66)  Gender, n (%) Male 181 (65.6%) 52 (62.7%) Female  95 (34.4%) 31 (37.3%) Malignancy, n (%) NA Benign  45 (16.3%) Malignant 231 (83.7%) Pathologic T stage, n (%) NA pT1-pT2 147 (63.6%) pT3-pT4  84 (36.4%) Pathologic grade, n (%) NA G1-G2 138 (59.7%) G3-G4  93 (40.3%) Clinicalmetastasis, n (%) NA cM0 242 (87.7%) cM1  34 (12.3%)

In the subgroup of patients where miRNAs were analyzed the inventors considered 120 case patients vs 78 controls with the previous same clinical and pathological criteria.

Medium age was 66 years old for renal mass pts while 57 years old for controls. Male/female percentages were 54.2% vs 45.8% for cases and 62.82% vs 37.18% for controls.

Patients affected by a benign lesion were 21.7%. High stage tumours were 28.7% and high-grade neoplasms were 28.7%, with a discrepancy of 15% between stage and grade classifications. Metastatic patients were the 6.7% of the total malignant cancers (Table 3).

TABLE 3 Descriptive analysis of miRNAs total cohort of patients Renal mass patients Controls Number of patients, n 120 78 Age, median (range) 66 (54-73)  57 (49-66)  Gender, n (%) Male 65 (54.2%) 49 (62.8%) Female 55 (45.8%) 29 (37.2%) Malignancy, n (%) NA Benign 26 (21.7%) Malignant 94 (78.3%) Pathologic T stage, n (%) NA pT1-pT2 67 (71.3%) pT3-pT4 27 (28.7%) Pathologic grade, n (%) NA G1-G2 66 (71.3%) G3-G4 28 (28.7%) Clinicalmetastasis, n (%) NA cM0 112 (93.3%)  cM1 8 (6.7%)

Then, the inventors decided to consider for the miRNAs analysis also a restricted cohort of patients related to the prospective multicentric study (Table 4).

TABLE 4 Descriptive analysis of miRNAs prospective multicentric cohort of patients Renal mass patients Controls Number of patients, n 59 51 Age, median (range) 66 (59-75)  59 (53-67)  Gender, n (%) Male 37 (62.7%) 35 (68.6%) Female 27 (37.3%) 16 (31.4%) Malignancy, n (%) NA Benign 17 (28.8%) Malignant 42 (72.2%) Pathologic T stage, n (%) NA pT1-pT2 34 (81%)  pT3-pT4 8 (19%)  Pathologic grade, n (%) NA G1-G2 31 (73.8%) G3-G4 11 (26.2%) Clinicalmetastasis, n (%) NA cM0 58 (98.3%) cM1 1 (1.7%)

Medium age was 66 years old for renal mass pts while 59 years old for controls. Male/female percentages were 62.7% vs 37.3% for cases and 68.6% vs 31.4% for controls.

Patients affected by a benign lesion were 28.8%. High stage tumours were 19% and high-grade neoplasms were 26.2%, with a discrepancy of 15% between stage and grade classifications. Only one patient was affected by metastasis (1.7%).

Methods

Single Nucleotide Polymorphisms (SNPs) Genotyping in the UMOD Gene

Genomic DNA was extracted from whole blood, leukocytes, or normal kidney tissue (depending on individual sample availability) using the QIAamp DNA Mini Kit (QIAGEN), according to manufacturer's instructions. Purity and concentration of recovered DNA were determined with a NanoDrop spectrophotometer (ND-1000, NanoDrop Technologies, Wilmington, Del., USA). Genotyping of 22 single nucleotide polymorphisms (SNPs) in the UMOD gene (r54293393 (ASSAY ID C_27865986_10), rs13335818 (ASSAY ID C_136431_10), rs28544423 (ASSAY ID C_136432_20), rs11647727 (ASSAY ID C_11844689_10), rs28640218 (ASSAY ID C_27398349_10), rs12934320 (ASSAY ID C_27435435_10), rs12934455 (ASSAY ID C_27435436_10), rs34356953 (ASSAY ID C_27435446_10), rs7193058 (ASSAY ID C_29095382_10), rs4297685 (ASSAY ID C_30368496_10), rs9928757 (ASSAY ID C_30613644_10), rs13333226 (ASSAY ID C_31122293_10), rs11862974 (ASSAY ID C_31122295_10), rs13329952 (ASSAY ID C_31122297_10), rs12917707 (ASSAY ID C_31122302_20), rs28362063 (ASSAY ID C_60216431_10), rs28688991 (ASSAY ID C_60216441_10), rs60136849 (ASSAY ID C_89248696_10), rs71384446 (ASSAY ID C_97852849_10), rs76563024 (ASSAY ID C_102020079_10), rs7203642 (ASSAY ID C_189262956_10), rs7204342 (ASSAY ID C_189263753_10), ThermoFisher, Cat. No.: 4351379) was performed by using the TaqMan Open Array technology (ThermoFisher), following the manufacturer's protocol. DNA was combined with TaqMan OpenArray Genotyping Master Mix, loaded onto the OpenArray™ plates (AccuFill™ system, Cat. No. 4471021) and amplified with the QuantStudio 12K Flex Real-Time PCR System (ThermoFisher, Cat. No. 4472379). All analyses were performed in duplicate to ensure reproducibility of the results. Human gDNA samples from the NHGRI Sample Repository for Human Genetic Research at Coriell Institute for Medical Research were also included as positive controls for each variant, as well as non-template control (NTC), consisting of DNase-free double-distilled water.

Genotype clustering and calling were carried out by using TaqMan Genotyper Software version 1.5 (call rate 99.14%; ThermoFisher).

TaqMan MicroRNA Profiling Using the QuantStudio 12K Flex Real-Time PCR System with OpenArray

Total RNA was isolated from 200 μL of plasma using miRNeasy Serum/Plasma Advanced Kit (QIAGEN, Cat No. 217204) according to manufacturer's instructions, with a little modification. Briefly, during the isolation procedure, 0.001 pmol of synthetic miRNA-39 from Caenorhabditis elegans (cel-miR-39, Accession number MIMAT0000010 miRBase v22, synthesized by ThermoFisher) was added as a spike-in control before the addition of Buffer RPP. In humans, a cel-miR-39-sequence does not exist and thus its quantification enables quality control of the RNA isolation, cDNA synthesis and PCR amplification steps.

cDNA was generated using 2 μl of purified total RNA with the TaqMan Advanced miRNA cDNA Synthesis kit (ThermoFisher, Cat. No. A28007). Expression levels of 668 miRNAs (hsa-let-7a-3p (Assay ID 477861_mir), hsa-let-7a-5p (Assay ID 478575_mir), hsa-let-7b-3p (Assay ID 478221_mir), hsa-let-7b-5p (Assay ID 478576_mir), hsa-let-7c-5p (Assay ID 478577_mir), hsa-let-7d-3p (Assay ID 477848_mir), hsa-let-7d-5p (Assay ID 478439_mir), hsa-let-7e-3p (Assay ID 479281_mir), hsa-let-7e-5p (Assay ID 478579_mir), hsa-let-7f-1-3p (Assay ID 477801_mir), hsa-let-7f-2-3p (Assay ID 477843_mir), hsa-let-7f-5p (Assay ID 478578_mir), hsa-let-7g-3p (Assay ID 477850_mir), hsa-let-7g-5p (Assay ID 478580_mir), hsa-let-7i-3p (Assay ID 477862_mir), hsa-let-7i-5p (Assay ID 478375_mir), hsa-miR-100-3p (Assay ID 478619_mir), hsa-miR-100-5p (Assay ID 478224_mir), hsa-miR-101-3p (Assay ID 477863_mir), hsa-miR-101-5p (Assay ID 478620_mir), hsa-miR-10399-3p (Assay ID 483065_mir), hsa-miR-10399-5p (Assay ID 483087_mir), hsa-miR-103a-2-5p (Assay ID 477864_mir), hsa-miR-103a-3p (Assay ID 478253_mir), hsa-miR-103b (Assay ID 478621_mir), hsa-miR-106a-3p (Assay ID 478623_mir), hsa-miR-106a-5p (Assay ID 478225_mir), hsa-miR-106b-3p (Assay ID 477866_mir), hsa-miR-106b-5p (Assay ID 478412_mir), hsa-miR-107 (Assay ID 478254_mir), hsa-miR-10a-3p (Assay ID 478624_mir), hsa-miR-10a-5p (Assay ID 479241_mir), hsa-miR-10b-3p (Assay ID 477868_mir), hsa-miR-10b-5p (Assay ID 478494_mir), hsa-miR-11400 (Assay ID 483092_mir), hsa-miR-1179 (Assay ID 478626_mir), hsa-miR-1180-3p (Assay ID 477869_mir), hsa-miR-1185-5p (Assay ID 480633_mir), hsa-miR-1197 (Assay ID 478630_mir), hsa-miR-12116 (Assay ID 483094_mir), hsa-miR-12118 (Assay ID 483119_mir), hsa-miR-12135 (Assay ID 483153_mir), hsa-miR-12136 (Assay ID 483118_mir), hsa-miR-122-3p (Assay ID 477874_mir), hsa-miR-122-5p (Assay ID 477855_mir), hsa-miR-1226-5p (Assay ID 478641_mir), hsa-miR-1227-3p (Assay ID 478642_mir), hsa-miR-1228-5p (Assay ID 478644_mir), hsa-miR-122b-3p (Assay ID 479677_mir), hsa-miR-124-3p (Assay ID 480901_mir), hsa-miR-1246 (Assay ID 477881_mir), hsa-miR-1247-5p (Assay ID 477882_mir), hsa-miR-1248 (Assay ID 478653_mir), hsa-miR-1249-3p (Assay ID 478654_mir), hsa-miR-1250-5p (Assay ID 478655_mir), hsa-miR-1255a (Assay ID 478661_mir), hsa-miR-1255b-5p (Assay ID 478662_mir), hsa-miR-1256 (Assay ID 478663_mir), hsa-miR-125a-3p (Assay ID 477883_mir), hsa-miR-125a-5p (Assay ID 477884_mir), hsa-miR-125b-2-3p (Assay ID 478666_mir), hsa-miR-125b-5p (Assay ID 477885_mir), hsa-miR-1260a (Assay ID 478476_mir), hsa-miR-1260b (Assay ID 477886_mir), hsa-miR-126-3p (Assay ID 477887_mir), hsa-miR-126-5p (Assay ID 477888_mir), hsa-miR-1268b (Assay ID 480790_mir), hsa-miR-1270 (Assay ID 478673_mir), hsa-miR-1271-5p (Assay ID 478674_mir), hsa-miR-1273h-3p (Assay ID 479563_mir), hsa-miR-127-3p (Assay ID 477889_mir), hsa-miR-1275 (Assay ID 477890_mir), hsa-miR-127-5p (Assay ID 477891_mir), hsa-miR-1277-3p (Assay ID 478219_mir), hsa-miR-1277-5p (Assay ID 480875_mir), hsa-miR-1283 (Assay ID 478685_mir), hsa-miR-128-3p (Assay ID 477892_mir), hsa-miR-1284 (Assay ID 478686_mir), hsa-miR-1285-3p (Assay ID 478687_mir), hsa-miR-1285-5p (Assay ID 479565_mir), hsa-miR-1287-5p (Assay ID 477894_mir), hsa-miR-1290 (Assay ID 477895_mir), hsa-miR-1291 (Assay ID 478690_mir), hsa-miR-129-1-3p (Assay ID 480873_mir), hsa-miR-129-2-3p (Assay ID 478544_mir), hsa-miR-1292-5p (Assay ID 478691_mir), hsa-miR-1293 (Assay ID 478692_mir), hsa-miR-1294 (Assay ID 478693_mir), hsa-miR-129-5p (Assay ID 477896_mir), hsa-miR-1296-5p (Assay ID 479451_mir), hsa-miR-1298-5p (Assay ID 479452_mir), hsa-miR-1299 (Assay ID 478696_mir), hsa-miR-1301-3p (Assay ID 477897_mir), hsa-miR-1302 (Assay ID 478697_mir), hsa-miR-1303 (Assay ID 478698_mir), hsa-miR-1306-3p (Assay ID 479575_mir), hsa-miR-1306-5p (Assay ID 478701_mir), hsa-miR-1307-3p (Assay ID 483036_mir), hsa-miR-1307-5p (Assay ID 479576_mir), hsa-miR-130a-3p (Assay ID 477851_mir), hsa-miR-130a-5p (Assay ID 483130_mir), hsa-miR-130b-3p (Assay ID 477840_mir), hsa-miR-130b-5p (Assay ID 477899_mir), hsa-miR-132-3p (Assay ID 477900_mir), hsa-miR-132-5p (Assay ID 478705_mir), hsa-miR-133a-3p (Assay ID 478511_mir), hsa-miR-133b (Assay ID 480871_mir), hsa-miR-134-5p (Assay ID 477901_mir), hsa-miR-135a-5p (Assay ID 478581_mir), hsa-miR-136-3p (Assay ID 477902_mir), hsa-miR-136-5p (Assay ID 478307_mir), hsa-miR-137-3p (Assay ID 477904_mir), hsa-miR-138-5p (Assay ID 477905_mir), hsa-miR-139-3p (Assay ID 477906_mir), hsa-miR-139-5p (Assay ID 478312_mir), hsa-miR-1-3p (Assay ID 477820_mir), hsa-miR-140-3p (Assay ID 477908_mir), hsa-miR-140-5p (Assay ID 477909_mir), hsa-miR-141-3p (Assay ID 478501_mir), hsa-miR-142-3p (Assay ID 477910_mir), hsa-miR-142-5p (Assay ID 477911_mir), hsa-miR-143-3p (Assay ID 477912_mir), hsa-miR-143-5p (Assay ID 478713_mir), hsa-miR-144-3p (Assay ID 477913_mir), hsa-miR-144-5p (Assay ID 477914_mir), hsa-miR-145-3p (Assay ID 477915_mir), hsa-miR-145-5p (Assay ID 477916_mir), hsa-miR-146a-3p (Assay ID 478714_mir), hsa-miR-146a-5p (Assay ID 478399_mir), hsa-miR-146b-3p (Assay ID 483103_mir), hsa-miR-146b-5p (Assay ID 483144_mir), hsa-miR-148a-3p (Assay ID 477814_mir), hsa-miR-148a-5p (Assay ID 478718_mir), hsa-miR-148b-3p (Assay ID 477824_mir), hsa-miR-148b-5p (Assay ID 478719_mir), hsa-miR-150-3p (Assay ID 478721_mir), hsa-miR-150-5p (Assay ID 477918_mir), hsa-miR-151a-3p (Assay ID 477919_mir), hsa-miR-151a-5p (Assay ID 478505_mir), hsa-miR-151b (Assay ID 477811_mir), hsa-miR-152-3p (Assay ID 477921_mir), hsa-miR-153-3p (Assay ID 477922_mir), hsa-miR-1537-3p (Assay ID 477923_mir), hsa-miR-154-3p (Assay ID 478725_mir), hsa-miR-154-5p (Assay ID 477925_mir), hsa-miR-155-5p (Assay ID 483064_mir), hsa-miR-15a-3p (Assay ID 477928_mir), hsa-miR-15a-5p (Assay ID 477858_mir), hsa-miR-15b-3p (Assay ID 477929_mir), hsa-miR-15b-5p (Assay ID 478313_mir), hsa-miR-16-1-3p (Assay ID 478727_mir), hsa-miR-16-2-3p (Assay ID 477931_mir), hsa-miR-16-5p (Assay ID 477860_mir), hsa-miR-17-3p (Assay ID 477932_mir), hsa-miR-17-5p (Assay ID 478447_mir), hsa-miR-181a-2-3p (Assay ID 479478_mir), hsa-miR-181a-3p (Assay ID 479405_mir), hsa-miR-181a-5p (Assay ID 477857_mir), hsa-miR-181b-5p (Assay ID 478583_mir), hsa-miR-181c-3p (Assay ID 477933_mir), hsa-miR-181c-5p (Assay ID 477934_mir), hsa-miR-181d-5p (Assay ID 479517_mir), hsa-miR-182-5p (Assay ID 477935_mir), hsa-miR-183-3p (Assay ID 477936_mir), hsa-miR-183-5p (Assay ID 477937_mir), hsa-miR-184 (Assay ID 477938_mir), hsa-miR-1843 (Assay ID 483104_mir), hsa-miR-185-3p (Assay ID 478732_mir), hsa-miR-185-5p (Assay ID 477939_mir), hsa-miR-186-3p (Assay ID 479544_mir), hsa-miR-186-5p (Assay ID 477940_mir), hsa-miR-187-3p (Assay ID 477941_mir), hsa-miR-188-3p (Assay ID 477942_mir), hsa-miR-188-5p (Assay ID 477943_mir), hsa-miR-18a-3p (Assay ID 477944_mir), hsa-miR-18a-5p (Assay ID 478551_mir), hsa-miR-18b-3p (Assay ID 478734_mir), hsa-miR-18b-5p (Assay ID 478584_mir), hsa-miR-1908-5p (Assay ID 478735_mir), hsa-miR-190a-5p (Assay ID 478358_mir), hsa-miR-190b-5p (Assay ID 483105_mir), hsa-miR-191-3p (Assay ID 477951_mir), hsa-miR-191-5p (Assay ID 477952_mir), hsa-miR-192-3p (Assay ID 478741_mir), hsa-miR-192-5p (Assay ID 478262_mir), hsa-miR-193a-3p (Assay ID 478306_mir), hsa-miR-193a-5p (Assay ID 477954_mir), hsa-miR-193b-3p (Assay ID 478314_mir), hsa-miR-193b-5p (Assay ID 478742_mir), hsa-miR-194-5p (Assay ID 477956_mir), hsa-miR-195-3p (Assay ID 478744_mir), hsa-miR-195-5p (Assay ID 477957_mir), hsa-miR-196a-5p (Assay ID 478230_mir), hsa-miR-196b-3p (Assay ID 477958_mir), hsa-miR-196b-5p (Assay ID 478585_mir), hsa-miR-197-3p (Assay ID 477959_mir), hsa-miR-1976 (Assay ID 478365_mir), hsa-miR-199a-3p (Assay ID 477961_mir), hsa-miR-199a-5p (Assay ID 478231_mir), hsa-miR-199b-5p (Assay ID 478486_mir), hsa-miR-19a-3p (Assay ID 479228_mir), hsa-miR-19b-1-5p (Assay ID 477962_mir), hsa-miR-19b-3p (Assay ID 478264_mir), hsa-miR-200a-3p (Assay ID 478490_mir), hsa-miR-200b-3p (Assay ID 477963_mir), hsa-miR-200c-3p (Assay ID 478351_mir), hsa-miR-202-5p (Assay ID 478755_mir), hsa-miR-203a-3p (Assay ID 478316_mir), hsa-miR-203b-3p (Assay ID 478757_mir), hsa-miR-203b-5p (Assay ID 478758_mir), hsa-miR-204-5p (Assay ID 478491_mir), hsa-miR-205-5p (Assay ID 477967_mir), hsa-miR-206 (Assay ID 477968_mir), hsa-miR-208a-3p (Assay ID 477819_mir), hsa-miR-208b-3p (Assay ID 477806_mir), hsa-miR-20a-3p (Assay ID 478317_mir), hsa-miR-20a-5p (Assay ID 478586_mir), hsa-miR-20b-5p (Assay ID 477804_mir), hsa-miR-210-3p (Assay ID 477970_mir), hsa-miR-2110 (Assay ID 477971_mir), hsa-miR-211-5p (Assay ID 478507_mir), hsa-miR-212-3p (Assay ID 478318_mir), hsa-miR-21-3p (Assay ID 477973_mir), hsa-miR-214-3p (Assay ID 477974_mir), hsa-miR-214-5p (Assay ID 478768_mir), hsa-miR-215-5p (Assay ID 478516_mir), hsa-miR-21-5p (Assay ID 477975_mir), hsa-miR-216b-5p (Assay ID 479456_mir), hsa-miR-218-5p (Assay ID 477977_mir), hsa-miR-219a-1-3p (Assay ID 477978_mir), hsa-miR-219a-5p (Assay ID 477980_mir), hsa-miR-219b-3p (Assay ID 478776_mir), hsa-miR-221-3p (Assay ID 477981_mir), hsa-miR-221-5p (Assay ID 478778_mir), hsa-miR-222-3p (Assay ID 477982_mir), hsa-miR-223-3p (Assay ID 477983_mir), hsa-miR-223-5p (Assay ID 477984_mir), hsa-miR-22-3p (Assay ID 477985_mir), hsa-miR-224-3p (Assay ID 478780_mir), hsa-miR-224-5p (Assay ID 483106_mir), hsa-miR-22-5p (Assay ID 477987_mir), hsa-miR-2355-3p (Assay ID 477989_mir), hsa-miR-23a-3p (Assay ID 478532_mir), hsa-miR-23a-5p (Assay ID 478782_mir), hsa-miR-23b-3p (Assay ID 483150_mir), hsa-miR-23b-5p (Assay ID 477991_mir), hsa-miR-24-1-5p (Assay ID 478784_mir), hsa-miR-24-2-5p (Assay ID 478785_mir), hsa-miR-24-3p (Assay ID 477992_mir), hsa-miR-25-3p (Assay ID 477994_mir), hsa-miR-25-5p (Assay ID 478786_mir), hsa-miR-26a-1-3p (Assay ID 478787_mir), hsa-miR-26a-5p (Assay ID 477995_mir), hsa-miR-26b-3p (Assay ID 483077_mir), hsa-miR-26b-5p (Assay ID 478418_mir), hsa-miR-27a-3p (Assay ID 478384_mir), hsa-miR-27a-5p (Assay ID 477998_mir), hsa-miR-27b-3p (Assay ID 478270_mir), hsa-miR-27b-5p (Assay ID 478789_mir), hsa-miR-28-3p (Assay ID 477999_mir), hsa-miR-28-5p (Assay ID 478000_mir), hsa-miR-296-5p (Assay ID 477836_mir), hsa-miR-299-3p (Assay ID 478792_mir), hsa-miR-299-5p (Assay ID 478793_mir), hsa-miR-29a-3p (Assay ID 478587_mir), hsa-miR-29a-5p (Assay ID 478002_mir), hsa-miR-29b-1-5p (Assay ID 478794_mir), hsa-miR-29b-2-5p (Assay ID 478003_mir), hsa-miR-29b-3p (Assay ID 478369_mir), hsa-miR-29c-3p (Assay ID 479229_mir), hsa-miR-29c-5p (Assay ID 478005_mir), hsa-miR-301a-3p (Assay ID 477815_mir), hsa-miR-301b-3p (Assay ID 477825_mir), hsa-miR-302b-3p (Assay ID 478591_mir), hsa-miR-302d-3p (Assay ID 478237_mir), hsa-miR-3065-3p (Assay ID 479605_mir), hsa-miR-3065-5p (Assay ID 478802_mir), hsa-miR-3074-5p (Assay ID 479606_mir), hsa-miR-30a-3p (Assay ID 478273_mir), hsa-miR-30a-5p (Assay ID 479448_mir), hsa-miR-30b-3p (Assay ID 478804_mir), hsa-miR-30b-5p (Assay ID 478007_mir), hsa-miR-30c-1-3p (Assay ID 479412_mir), hsa-miR-30c-5p (Assay ID 478008_mir), hsa-miR-30d-5p (Assay ID 478606_mir), hsa-miR-30e-3p (Assay ID 478388_mir), hsa-miR-30e-5p (Assay ID 479235_mir), hsa-miR-3115 (Assay ID 479607_mir), hsa-miR-3120-3p (Assay ID 478009_mir), hsa-miR-3120-5p (Assay ID 479611_mir), hsa-miR-3130-5p (Assay ID 479621_mir), hsa-miR-31-3p (Assay ID 478012_mir), hsa-miR-3140-3p (Assay ID 479626_mir), hsa-miR-3158-5p (Assay ID 479644_mir), hsa-miR-31-5p (Assay ID 478015_mir), hsa-miR-3173-5p (Assay ID 479656_mir), hsa-miR-3177-3p (Assay ID 479658_mir), hsa-miR-3184-3p (Assay ID 479662_mir), hsa-miR-3184-5p (Assay ID 478817_mir), hsa-miR-3194-5p (Assay ID 479673_mir), hsa-miR-320a-3p (Assay ID 478594_mir), hsa-miR-320b (Assay ID 478588_mir), hsa-miR-320e (Assay ID 478022_mir), hsa-miR-323a-3p (Assay ID 477853_mir), hsa-miR-323b-3p (Assay ID 478825_mir), hsa-miR-323b-5p (Assay ID 478826_mir), hsa-miR-32-3p (Assay ID 478827_mir), hsa-miR-324-3p (Assay ID 483109_mir), hsa-miR-324-5p (Assay ID 483066_mir), hsa-miR-325 (Assay ID 478025_mir), hsa-miR-32-5p (Assay ID 478026_mir), hsa-miR-326 (Assay ID 478027_mir), hsa-miR-328-3p (Assay ID 478028_mir), hsa-miR-329-3p (Assay ID 478029_mir), hsa-miR-330-3p (Assay ID 478030_mir), hsa-miR-330-5p (Assay ID 478830_mir), hsa-miR-331-3p (Assay ID 478323_mir), hsa-miR-331-5p (Assay ID 478032_mir), hsa-miR-335-3p (Assay ID 478033_mir), hsa-miR-335-5p (Assay ID 478324_mir), hsa-miR-337-3p (Assay ID 478035_mir), hsa-miR-337-5p (Assay ID 478036_mir), hsa-miR-338-3p (Assay ID 478037_mir), hsa-miR-338-5p (Assay ID 478038_mir), hsa-miR-339-3p (Assay ID 478325_mir), hsa-miR-339-5p (Assay ID 478040_mir), hsa-miR-33a-3p (Assay ID 478831_mir), hsa-miR-33a-5p (Assay ID 478347_mir), hsa-miR-33b-5p (Assay ID 478479_mir), hsa-miR-340-3p (Assay ID 478041_mir), hsa-miR-340-5p (Assay ID 478042_mir), hsa-miR-342-3p (Assay ID 478043_mir), hsa-miR-342-5p (Assay ID 478044_mir), hsa-miR-345-5p (Assay ID 478366_mir), hsa-miR-346 (Assay ID 478046_mir), hsa-miR-34a-3p (Assay ID 478047_mir), hsa-miR-34a-5p (Assay ID 478048_mir), hsa-miR-34c-3p (Assay ID 478051_mir), hsa-miR-34c-5p (Assay ID 478052_mir), hsa-miR-3529-3p (Assay ID 480652_mir), hsa-miR-3611 (Assay ID 480655_mir), hsa-miR-3613-3p (Assay ID 478434_mir), hsa-miR-3613-5p (Assay ID 479424_mir), hsa-miR-361-3p (Assay ID 478055_mir), hsa-miR-3615 (Assay ID 478837_mir), hsa-miR-361-5p (Assay ID 478056_mir), hsa-miR-362-3p (Assay ID 478058_mir), hsa-miR-362-5p (Assay ID 478059_mir), hsa-miR-363-3p (Assay ID 478060_mir), hsa-miR-363-5p (Assay ID 478840_mir), hsa-miR-365a-3p (Assay ID 478065_mir), hsa-miR-3667-5p (Assay ID 479704_mir), hsa-miR-367-3p (Assay ID 478066_mir), hsa-miR-369-3p (Assay ID 478067_mir), hsa-miR-369-5p (Assay ID 478068_mir), hsa-miR-370-3p (Assay ID 478326_mir), hsa-miR-373-3p (Assay ID 478363_mir), hsa-miR-373-5p (Assay ID 478073_mir), hsa-miR-374a-3p (Assay ID 478855_mir), hsa-miR-374a-5p (Assay ID 478238_mir), hsa-miR-374b-3p (Assay ID 479421_mir), hsa-miR-374b-5p (Assay ID 478389_mir), hsa-miR-374c-3p (Assay ID 478856_mir), hsa-miR-375-3p (Assay ID 478074_mir), hsa-miR-376a-2-5p (Assay ID 478858_mir), hsa-miR-376a-3p (Assay ID 478240_mir), hsa-miR-376a-5p (Assay ID 478859_mir), hsa-miR-376b-3p (Assay ID 478860_mir), hsa-miR-376b-5p (Assay ID 478861_mir), hsa-miR-376c-3p (Assay ID 478459_mir), hsa-miR-377-3p (Assay ID 478075_mir), hsa-miR-377-5p (Assay ID 478863_mir), hsa-miR-378a-3p (Assay ID 478349_mir), hsa-miR-378a-5p (Assay ID 478076_mir), hsa-miR-378c (Assay ID 478864_mir), hsa-miR-3781 (Assay ID 478305_mir), hsa-miR-379-5p (Assay ID 478077_mir), hsa-miR-380-3p (Assay ID 477854_mir), hsa-miR-381-3p (Assay ID 477816_mir), hsa-miR-381-5p (Assay ID 478866_mir), hsa-miR-382-3p (Assay ID 479458_mir), hsa-miR-382-5p (Assay ID 478078_mir), hsa-miR-3913-3p (Assay ID 479734_mir), hsa-miR-3913-5p (Assay ID 479735_mir), hsa-miR-3928-3p (Assay ID 479749_mir), hsa-miR-3940-3p (Assay ID 479759_mir), hsa-miR-409-3p (Assay ID 478084_mir), hsa-miR-409-5p (Assay ID 478872_mir), hsa-miR-410-3p (Assay ID 478085_mir), hsa-miR-411-3p (Assay ID 479526_mir), hsa-miR-411-5p (Assay ID 478086_mir), hsa-miR-421 (Assay ID 478088_mir), hsa-miR-422a (Assay ID 478481_mir), hsa-miR-423-3p (Assay ID 478327_mir), hsa-miR-423-5p (Assay ID 478090_mir), hsa-miR-424-3p (Assay ID 478091_mir), hsa-miR-424-5p (Assay ID 478092_mir), hsa-miR-4253 (Assay ID 480774_mir), hsa-miR-425-3p (Assay ID 478093_mir), hsa-miR-425-5p (Assay ID 478094_mir), hsa-miR-4286 (Assay ID 478096_mir), hsa-miR-429 (Assay ID 477849_mir), hsa-miR-4306 (Assay ID 478392_mir), hsa-miR-431-3p (Assay ID 478888_mir), hsa-miR-431-5p (Assay ID 478889_mir), hsa-miR-432-3p (Assay ID 478892_mir), hsa-miR-432-5p (Assay ID 478101_mir), hsa-miR-433-3p (Assay ID 478102_mir), hsa-miR-4429 (Assay ID 480852_mir), hsa-miR-4433a-3p (Assay ID 478897_mir), hsa-miR-4433a-5p (Assay ID 479801_mir), hsa-miR-4433b-3p (Assay ID 479802_mir), hsa-miR-4433b-5p (Assay ID 479803_mir), hsa-miR-4444 (Assay ID 479810_mir), hsa-miR-4446-3p (Assay ID 479812_mir), hsa-miR-4448 (Assay ID 480683_mir), hsa-miR-4454 (Assay ID 478104_mir), hsa-miR-4466 (Assay ID 483160_mir), hsa-miR-448 (Assay ID 478105_mir), hsa-miR-4488 (Assay ID 478906_mir), hsa-miR-449a (Assay ID 478561_mir), hsa-miR-450a-5p (Assay ID 478106_mir), hsa-miR-450b-3p (Assay ID 478913_mir), hsa-miR-450b-5p (Assay ID 478914_mir), hsa-miR-4516 (Assay ID 478303_mir), hsa-miR-451a (Assay ID 478107_mir), hsa-miR-4523 (Assay ID 479852_mir), hsa-miR-452-3p (Assay ID 478917_mir), hsa-miR-452-5p (Assay ID 478109_mir), hsa-miR-4537 (Assay ID 480691_mir), hsa-miR-4538 (Assay ID 478110_mir), hsa-miR-454-3p (Assay ID 478329_mir), hsa-miR-454-5p (Assay ID 478919_mir), hsa-miR-455-3p (Assay ID 478112_mir), hsa-miR-455-5p (Assay ID 478113_mir), hsa-miR-4662a-5p (Assay ID 479896_mir), hsa-miR-4669 (Assay ID 478925_mir), hsa-miR-4684-5p (Assay ID 479920_mir), hsa-miR-4685-3p (Assay ID 479921_mir), hsa-miR-4689 (Assay ID 478117_mir), hsa-miR-4690-3p (Assay ID 480702_mir), hsa-miR-4732-3p (Assay ID 478118_mir), hsa-miR-4732-5p (Assay ID 478119_mir), hsa-miR-4747-5p (Assay ID 480001_mir), hsa-miR-483-3p (Assay ID 478122_mir), hsa-miR-483-5p (Assay ID 478432_mir), hsa-miR-484 (Assay ID 478308_mir), hsa-miR-485-3p (Assay ID 478125_mir), hsa-miR-485-5p (Assay ID 478126_mir), hsa-miR-486-3p (Assay ID 478422_mir), hsa-miR-486-5p (Assay ID 478128_mir), hsa-miR-487a-3p (Assay ID 477826_mir), hsa-miR-487b-3p (Assay ID 477835_mir), hsa-miR-489-3p (Assay ID 478130_mir), hsa-miR-490-3p (Assay ID 478131_mir), hsa-miR-491-5p (Assay ID 478132_mir), hsa-miR-493-3p (Assay ID 478134_mir), hsa-miR-493-5p (Assay ID 478943_mir), hsa-miR-494-3p (Assay ID 478135_mir), hsa-miR-495-3p (Assay ID 478136_mir), hsa-miR-496 (Assay ID 478335_mir), hsa-miR-497-5p (Assay ID 478138_mir), hsa-miR-499a-5p (Assay ID 478139_mir), hsa-miR-499b-3p (Assay ID 478949_mir), hsa-miR-500a-3p (Assay ID 478951_mir), hsa-miR-500a-5p (Assay ID 478309_mir), hsa-miR-5010-3p (Assay ID 480086_mir), hsa-miR-501-3p (Assay ID 478350_mir), hsa-miR-501-5p (Assay ID 478142_mir), hsa-miR-502-3p (Assay ID 478348_mir), hsa-miR-502-5p (Assay ID 478954_mir), hsa-miR-503-5p (Assay ID 478143_mir), hsa-miR-504-5p (Assay ID 478144_mir), hsa-miR-505-3p (Assay ID 478145_mir), hsa-miR-505-5p (Assay ID 478957_mir), hsa-miR-509-3-5p (Assay ID 478963_mir), hsa-miR-5100 (Assay ID 480099_mir), hsa-miR-513b-5p (Assay ID 479297_mir), hsa-miR-513c-5p (Assay ID 479349_mir), hsa-miR-515-3p (Assay ID 478976_mir), hsa-miR-516a-5p (Assay ID 478978_mir), hsa-miR-516b-5p (Assay ID 478979_mir), hsa-miR-517a-3p (Assay ID 479485_mir), hsa-miR-517c-3p (Assay ID 479487_mir), hsa-miR-5187-5p (Assay ID 480101_mir), hsa-miR-518c-3p (Assay ID 478982_mir), hsa-miR-518d-3p (Assay ID 479393_mir), hsa-miR-518d-5p (Assay ID 479530_mir), hsa-miR-518e-3p (Assay ID 479408_mir), hsa-miR-518f-3p (Assay ID 478984_mir), hsa-miR-519a-3p (Assay ID 479534_mir), hsa-miR-519d-3p (Assay ID 478986_mir), hsa-miR-520d-3p (Assay ID 478990_mir), hsa-miR-520d-5p (Assay ID 478616_mir), hsa-miR-523-3p (Assay ID 478994_mir), hsa-miR-524-3p (Assay ID 479338_mir), hsa-miR-525-3p (Assay ID 478995_mir), hsa-miR-532-3p (Assay ID 478336_mir), hsa-miR-532-5p (Assay ID 478151_mir), hsa-miR-539-5p (Assay ID 478152_mir), hsa-miR-541-3p (Assay ID 478999_mir), hsa-miR-542-3p (Assay ID 478153_mir), hsa-miR-542-5p (Assay ID 478337_mir), hsa-miR-543 (Assay ID 478155_mir), hsa-miR-544a (Assay ID 478156_mir), hsa-miR-545-3p (Assay ID 479002_mir), hsa-miR-545-5p (Assay ID 479003_mir), hsa-miR-548a-3p (Assay ID 478157_mir), hsa-miR-548a-5p (Assay ID 479501_mir), hsa-miR-548aa (Assay ID 479004_mir), hsa-miR-548aj-5p (Assay ID 479009_mir), hsa-miR-548 am-5p (Assay ID 480872_mir), hsa-miR-548b-3p (Assay ID 479018_mir), hsa-miR-548b-5p (Assay ID 478589_mir), hsa-miR-548c-3p (Assay ID 479537_mir), hsa-miR-548d-3p (Assay ID 477833_mir), hsa-miR-548d-5p (Assay ID 480870_mir), hsa-miR-548e-3p (Assay ID 478362_mir), hsa-miR-548g-3p (Assay ID 479020_mir), hsa-miR-548h-5p (Assay ID 479503_mir), hsa-miR-5481 (Assay ID 480874_mir), hsa-miR-548j-5p (Assay ID 479022_mir), hsa-miR-548k (Assay ID 479374_mir), hsa-miR-5481 (Assay ID 479391_mir), hsa-miR-548m (Assay ID 479023_mir), hsa-miR-548n (Assay ID 479024_mir), hsa-miR-548p (Assay ID 479025_mir), hsa-miR-550a-3-5p (Assay ID 479031_mir), hsa-miR-550a-3p (Assay ID 479032_mir), hsa-miR-550a-5p (Assay ID 477852_mir), hsa-miR-550b-2-5p (Assay ID 479033_mir), hsa-miR-551a (Assay ID 478158_mir), hsa-miR-551b-3p (Assay ID 478159_mir), hsa-miR-552-3p (Assay ID 479036_mir), hsa-miR-553 (Assay ID 479038_mir), hsa-miR-556-3p (Assay ID 479041_mir), hsa-miR-5582-3p (Assay ID 480123_mir), hsa-miR-5588-5p (Assay ID 480135_mir), hsa-miR-562 (Assay ID 479047_mir), hsa-miR-570-3p (Assay ID 479053_mir), hsa-miR-574-3p (Assay ID 478163_mir), hsa-miR-574-5p (Assay ID 479357_mir), hsa-miR-576-3p (Assay ID 478164_mir), hsa-miR-576-5p (Assay ID 478165_mir), hsa-miR-579-3p (Assay ID 479059_mir), hsa-miR-580-3p (Assay ID 479061_mir), hsa-miR-582-5p (Assay ID 478166_mir), hsa-miR-583 (Assay ID 479065_mir), hsa-miR-584-5p (Assay ID 478167_mir), hsa-miR-585-3p (Assay ID 479067_mir), hsa-miR-589-3p (Assay ID 479072_mir), hsa-miR-589-5p (Assay ID 479073_mir), hsa-miR-590-3p (Assay ID 478168_mir), hsa-miR-590-5p (Assay ID 478367_mir), hsa-miR-592 (Assay ID 479075_mir), hsa-miR-593-3p (Assay ID 479076_mir), hsa-miR-597-5p (Assay ID 478339_mir), hsa-miR-598-3p (Assay ID 478172_mir), hsa-miR-605-5p (Assay ID 478174_mir), hsa-miR-606 (Assay ID 479087_mir), hsa-miR-608 (Assay ID 479089_mir), hsa-miR-615-3p (Assay ID 478175_mir), hsa-miR-616-5p (Assay ID 479099_mir), hsa-miR-618 (Assay ID 479101_mir), hsa-miR-619-5p (Assay ID 479103_mir), hsa-miR-624-3p (Assay ID 479108_mir), hsa-miR-624-5p (Assay ID 478178_mir), hsa-miR-625-3p (Assay ID 478179_mir), hsa-miR-625-5p (Assay ID 479469_mir), hsa-miR-627-3p (Assay ID 479111_mir), hsa-miR-627-5p (Assay ID 478427_mir), hsa-miR-628-3p (Assay ID 478181_mir), hsa-miR-628-5p (Assay ID 479112_mir), hsa-miR-629-3p (Assay ID 478182_mir), hsa-miR-629-5p (Assay ID 478183_mir), hsa-miR-633 (Assay ID 479115_mir), hsa-miR-636 (Assay ID 478185_mir), hsa-miR-641 (Assay ID 479120_mir), hsa-miR-642a-5p (Assay ID 479121_mir), hsa-miR-643 (Assay ID 479123_mir), hsa-miR-6501-5p (Assay ID 480194_mir), hsa-miR-6503-5p (Assay ID 480197_mir), hsa-miR-6513-5p (Assay ID 480213_mir), hsa-miR-651-5p (Assay ID 479131_mir), hsa-miR-652-3p (Assay ID 478189_mir), hsa-miR-652-5p (Assay ID 479132_mir), hsa-miR-653-5p (Assay ID 479134_mir), hsa-miR-654-3p (Assay ID 479135_mir), hsa-miR-654-5p (Assay ID 478368_mir), hsa-miR-655-3p (Assay ID 478191_mir), hsa-miR-656-3p (Assay ID 479137_mir), hsa-miR-660-3p (Assay ID 479143_mir), hsa-miR-660-5p (Assay ID 478192_mir), hsa-miR-663b (Assay ID 479146_mir), hsa-miR-664a-3p (Assay ID 478193_mir), hsa-miR-665 (Assay ID 479150_mir), hsa-miR-668-3p (Assay ID 479151_mir), hsa-miR-671-3p (Assay ID 478194_mir), hsa-miR-671-5p (Assay ID 483035_mir), hsa-miR-6727-5p (Assay ID 480235_mir), hsa-miR-6729-3p (Assay ID 480238_mir), hsa-miR-6734-5p (Assay ID 480247_mir), hsa-miR-6741-5p (Assay ID 480260_mir), hsa-miR-6748-3p (Assay ID 480270_mir), hsa-miR-675-5p (Assay ID 478196_mir), hsa-miR-6757-5p (Assay ID 480286_mir), hsa-miR-6765-5p (Assay ID 480300_mir), hsa-miR-6803-3p (Assay ID 480372_mir), hsa-miR-6852-5p (Assay ID 480461_mir), hsa-miR-6881-5p (Assay ID 480513_mir), hsa-miR-6882-5p (Assay ID 480515_mir), hsa-miR-708-3p (Assay ID 479162_mir), hsa-miR-708-5p (Assay ID 478197_mir), hsa-miR-7114-3p (Assay ID 480554_mir), hsa-miR-7-1-3p (Assay ID 478198_mir), hsa-miR-744-3p (Assay ID 479165_mir), hsa-miR-744-5p (Assay ID 478200_mir), hsa-miR-758-3p (Assay ID 479166_mir), hsa-miR-7-5p (Assay ID 483061_mir), hsa-miR-766-3p (Assay ID 478342_mir), hsa-miR-766-5p (Assay ID 479174_mir), hsa-miR-769-3p (Assay ID 479177_mir), hsa-miR-769-5p (Assay ID 478203_mir), hsa-miR-7704 (Assay ID 480576_mir), hsa-miR-770-5p (Assay ID 479178_mir), hsa-miR-7706 (Assay ID 480578_mir), hsa-miR-7847-3p (Assay ID 480584_mir), hsa-miR-7976 (Assay ID 480595_mir), hsa-miR-7977 (Assay ID 479180_mir), hsa-miR-8077 (Assay ID 480619_mir), hsa-miR-873-5p (Assay ID 478204_mir), hsa-miR-874-3p (Assay ID 478205_mir), hsa-miR-876-3p (Assay ID 479186_mir), hsa-miR-877-3p (Assay ID 477856_mir), hsa-miR-877-5p (Assay ID 478206_mir), hsa-miR-885-3p (Assay ID 479188_mir), hsa-miR-885-5p (Assay ID 478207_mir), hsa-miR-887-3p (Assay ID 479189_mir), hsa-miR-888-5p (Assay ID 479192_mir), hsa-miR-889-3p (Assay ID 478208_mir), hsa-miR-891a-5p (Assay ID 479196_mir), hsa-miR-92a-1-5p (Assay ID 479205_mir), hsa-miR-92a-3p (Assay ID 477827_mir), hsa-miR-92b-3p (Assay ID 477823_mir), hsa-miR-92b-5p (Assay ID 479207_mir), hsa-miR-933 (Assay ID 479208_mir), hsa-miR-93-3p (Assay ID 478209_mir), hsa-miR-935 (Assay ID 479210_mir), hsa-miR-93-5p (Assay ID 478210_mir), hsa-miR-937-3p (Assay ID 479212_mir), hsa-miR-939-5p (Assay ID 478245_mir), hsa-miR-9-3p (Assay ID 478211_mir), hsa-miR-941 (Assay ID 479217_mir), hsa-miR-942-5p (Assay ID 478212_mir), hsa-miR-943 (Assay ID 479219_mir), hsa-miR-944 (Assay ID 479220_mir), hsa-miR-95-3p (Assay ID 478213_mir), hsa-miR-9-5p (Assay ID 478214_mir), hsa-miR-96-5p (Assay ID 478215_mir), hsa-miR-98-3p (Assay ID 479223_mir), hsa-miR-98-5p (Assay ID 478590_mir), hsa-miR-99a-3p (Assay ID 479224_mir), hsa-miR-99a-5p (Assay ID 478519_mir), hsa-miR-99b-3p (Assay ID 478216_mir), hsa-miR-99b-5p (Assay ID 478343_mir), hsa-miR-199a-3p (Assay ID 477961_mir), hsa-miR-365a-3p (Assay ID 478065_mir), ThermoFisher, Cat. No. A25576), including cel-miR-39-3p (Assay ID 478293_mir, ThermoFisher, Cat. No. A25576), were quantified using the TaqMan Open Array technology (ThermoFisher), as per the manufacturer's instructions. cDNA was diluted 1:20 in 0.1×TE (pH 8.0), combined with TaqMan OpenArray Real-TimePCR Master Mix, loaded onto the OpenArray™ plates (AccuFill™ system, Cat. No. 4471021) and amplified with the QuantStudio 12K Flex Real-Time PCR System (ThermoFisher, Cat. No. 4472379). Technical duplicates were performed in each OpenArray™ plates. OpenArray® microRNA profiling data were processed and filtered using Python scripts. Briefly, QuantStudio 12K Flex Software assigns a Cq value and an Amplification score (Amp Score) and a Cq Confidence (Cq Conf.) value to each reaction for rapid assessment of data reliability. Data were filtered to exclude reactions with Amp Score <1.00, Cq Conf. <0.8, and Cq below 10 or above 28. In addition, a miRNA was considered as detected only if passes that criteria in at least 70% of the samples.

The concentrations from plasma samples were normalized using the global mean normalization method: the value of ΔCq was calculated by subtracting the mean of Cq values of all analyzed miRNAs from the mean of Cq values of each miRNA, in each patient sample. Statistical analysis was performed on the ΔCq values. In order to assess the change in gene expression, the values of ΔΔCq were then calculated by subtracting the mean of ΔCq of a group of samples from the mean of ΔCq of the comparison group of samples. The fold changes were calculated as 2^(−ΔΔCq).

Statistical Analysis

As regarding the analysis of UMOD genotype, the chi-square test was used to determine significant differences in genotype frequencies in the UMOD gene between different patients' groups, defined on the basis of the different outcomes (screening, diagnosis, and prognosis). As regarding the analysis of circulating plasma miRNAs, the Mann-Whitney test was used for the identification of statistically differentially regulated miRNAs between different patients' groups, defined on the basis of the different outcomes (screening, diagnosis, and prognosis). Any miRNA with Amp Score <1.00 and/or Cq Conf. <0.8 and/or Cq below 10 or above 28 in >30% of the samples were filtered out, resulting in 274 miRNAs, including cel-miR-39-3p. miRNAs which exhibit high percentage of missing values were removed only after checking through statistical test that the missingness pattern is not associated with the outcome.

The small percentage (1.68%) of missing values were imputed through an iterative procedure based on Bayesian Linear Regression. All statistical tests were two-sided with a significance level set at p<0.05 and were performed using python version 3.7.

In addition to this single biomarker analysis, a machine learning supervised classification of samples for the various forecasting tasks was performed by using Support Vector Machines (SVM) as implemented in the Scikit-Learn package for the python programming languages (python, version 3.7). As parameters, a linear kernel together with I1/I2 penalties and a cost parameter sampled from 0.01 to 10 was evaluated. As subset selection technique, a bootstrap simulation based on recursive feature elimination was used. This allowed to rank by importance the variables in analysis. A further reduction of the dimensionality of the obtained features was achieved by means of Bayesian optimisation. The most performing subsets were used to train the SVM and to carry out the prediction of the test samples in a 10-fold cross validation procedure (stratifying by outcome in order to account for class imbalances). To test for overfitting, permutation simulations were performed.

In order to evaluate the performances of each classification models the inventors investigated three different metrics: accuracy, recall, Receiver Operating Characteristic Area Under the Curve (ROC AUC). Accuracy is the ratio between the actual correctly predicted population on the total population. Recall is the ratio between the actual positive predicted population on all the positive predicted population. The ROC AUC is the area under the Receiver Operating Characteristic curve, created by plotting the recall against 1—specificity.

EXAMPLES Example 1: Variants in the UMOD Gene Associated with High Risk of RCC and High Risk of Aggressive RCC

The inventors have previously demonstrated in a cohort of 211 patients diagnosed with a renal mass and treated with surgery that the TT-rs4293393 variant in the UMOD gene is associated with a more aggressive clinical and pathological RCC phenotype and, in particular, with clinical metastasis, and high stage. [Trevisani et al., 2017].

The inventors extended their analysis to other 21 UMOD SNP variants: 15 (r512917707, rs12934320, rs12934455, rs13329952, rs13333226, rs13335818, rs28362063, rs28544423, rs28640218, rs28688991, rs34356953, rs60136849, rs71384446, rs7203642, r59928757) and 3 (r511647727, rs4297685, r57193058) SNPs in linkage disequilibrium (LD) with rs4293393 with a r²>0.8 and a 0.5≤r≤0.7, respectively; and 3 SNPs (r511862974, rs7204342, r576563024) not in LD with rs4293393 in the European/Caucasoid population.

Pairwise r² values for those SNPs are reported in FIG. 1 .

Those SNPs have a different location in the UMOD locus: 1 SNPs is upstream of UMOD gene promoter; 9 SNPs are in the UMOD gene promoter; 9 SNPs are intron variants, located in introns 1, 4, 5, and 7; and 3 SNPs are synonymous variant, two of them in the exon 3 and the other in the exon 4 (FIG. 2 ).

All those variants are important for different reasons: variants located in the UMOD gene promoter could be associated with an effect on gene expression [Trudu et al., 2013]; intronic variants can lead to pseudo-exon inclusion, due to activation of non-canonical splice sites or changes in splicing regulatory elements, or disrupt transcription regulatory motifs and non-coding RNA genes [Vaz-Drago et al., 2017]; synonymous variants could affect protein function altering RNA secondary structures, affecting RNA stability, and subsequently reducing protein expression [Nackley et al., 2006] and possibly affecting protein folding and function [Kimchi-Sarfaty et al. 2007]; synonymous variants could also affect splicing regulatory sequences as enhancers or silencers of splicing.

A total of 276 renal mass patients and 83 controls were genotyped for the 22 SNPs listed above. Minor allele frequencies (MAF), ranging from 0.03 to 0.3 (MAF observed), were similar to those reported in the literature (MAF (100Genome, EUR) (Table 4).

TABLE 4 Minor allele frequency (MAF) among the overall population (n = 359). bp Minor MAF MAF position SNP Allele (1000Genome, EUR) (observed) 20339137 rs71384446 G 0.25 0.23 20341541 rs9928757 G 0.23 0.20 20342493 rs60136849 G 0.20 0.18 20344843 rs11647727 T 0.28 0.30 20345004 rs34356953 A 0.20 0.18 20345933 rs12934320 A 0.20 0.18 20345959 rs12934455 A 0.19 0.15 20347945 rs28640218 A 0.21 0.20 20348311 rs28544423 A 0.20 0.18 20348509 rs13335818 A 0.20 0.18 20348779 rs7193058 C 0.28 0.30 20352517 rs76563024 C 0.01 0.03 20353266 rs4293393 C 0.20 0.18 20353690 rs28362063 G 0.20 0.18 20354332 rs13333226 C 0.20 0.19 20354903 rs11862974 T 0.01 0.03 20355185 rs13329952 G 0.22 0.21 20355808 rs7203642 C 0.22 0.20 20355917 rs7204342 A 0.01 0.04 20356228 rs28688991 A 0.22 0.22 20356368 rs12917707 A 0.20 0.18 20357242 rs4297685 G 0.33 0.30 * Information available at: http://www.ncbi.nlm.nih.gov/projects/SNP/.

For statistical analysis of the SNPs with a MAF between 0.03 and 0.23, the inventors grouped patients carrying one or two copies of the minor allele variant and compared them with patients homozygous for the major allele variant. For statistical analysis of rs11647727, rs7193058, and rs4297685 the inventors maintained the three genotypic classes.

As shown in Table 5, rs4293393 as well as 14 SNPs having strong or perfect LD (linkage disequilibrium) with rs4293393 (r513333226, rs12917707, rs13335818, rs28362063, rs28544423, rs34356953, rs60136849, rs12934320, rs13329952, rs28688991, rs7203642, rs9928757, rs12934455, r528640218) were significantly associated with pT3-pT4 stage, most of them showing a very similar or identical p value, as expected, ranging from 0.001 and 0.01. Only rs71384446, even if in LD with rs4293393 with a r²>0.8, were not significantly associated with pT3-pT4 stage with a p value of 0.06, which could reach statistical significance by increasing the study cohort.

On the other hand, none of the SNPs having a weak or no LD with rs4293393 were significantly associated with pT3-pT4 stage. Only rs11647727 showed a p value of 0.05, at the limits of significance.

TABLE 5 Association between UMOD SNP variants and higher pathologic T stage (pT3-pT4). RCC patients p SNP Variable (n = 231) Genotypic frequencies (%) value rs71384446 0.06 pT3-pT4 84 GG + GT 30.95 TT 68.05 pT1-pT2 147 GG + GT 43.54 TT 56.46 rs9928757 0.009 pT3-pT4 84 GG + CG 22.62 CC 77.38 pT1-pT2 147 GG + CG 39.46 CC 60.54 rs63136849 0.004 pT3-pT4 84 GG + GA 19.05 AA 80.95 pT1-pT2 147 GG + GA 37.41 AA 62.59 rs11647727 0.05 pT3-pT4 84 TT 2.38 CT 34.52 CC 63.10 pT1-pT2 147 TT 6.80 CT 45.58 CC 47.62 rs34356953 0.003 pT3-pT4 84 AA + AC 19.05 CC 80.95 pT1-pT2 147 AA + AC 38.10 CC 61.90 rs12934320 0.005 pT3-pT4 84 AA + AG 19.05 GG 80.95 pT1-pT2 147 AA + AG 36.73 GG 63.27 rs12934455 0.01 pT3-pT4 84 AA + AG 16.67 GG 83.33 pT1-pT2 147 AA + AG 31.97 GG 68.03 rs2

218 0.01 pT3-pT4 84 AA + AC 22.62 CC 77.38 pT1-pT2 147 AA + AC 38.78 CC 61.22 rs28544423 0.003 pT3-pT4 84 AA + AG 19.05 GG 80.95 pT1-pT2 147 AA + AG 38.10 GG 61.90 rs13335818 0.003 pT3-pT4 84 AA + AG 19.05 GG 80.95 pT1-pT2 147 AA + AG 38.10 GG 61.90 rs7193058 0.2 pT3-pT4 84 CC 3.57 CT 34.52 TT 61.90 pT1-pT2 147 CC 7.48 CT 42.86 TT 49.66 rs76563024 0.6 pT3-pT4 84 CC + CT 4.76 TT 95.24 pT1-pT2 147 CC + CT 3.40 TT 96.

rs429

0.003 pT3-pT4 84 CC + CT 19.05 TT 80.95 pT1-pT2 147 CC + CT 38.10 TT 61.90 rs28362063 0.003 pT3-pT4 84 GG + AG 19.05 AA 80.95 pT1-pT2 147 GG + AG 38.10 AA 61.90 rs13333226 0.001 pT3-pT4 84 CC + CT 19.05 TT 80.95 pT1-pT2 147 CC + CT 39.46 TT 80.54 rs11862974 0.8 pT3-pT4 84 TT + GT 4.76 GG 95.24 pT1-pT2 147 TT + GT 5.44 GG 94.56 rs13329952 0.005 pT3-pT4 84 GG + AG 23.81 AA 76.19 pT1-pT2 147 GG + AG 42.18 AA 57.82 rs7203642 0.007 pT3-pT4 84 CC + CT 23.81 TT 76.19 pT1-pT2 147 CC + CT 41.50 TT 58.50 rs7204342 0.8 pT3-pT4 84 AA + AC 4.76 CC 95.24 pT1-pT2 147 AA + AC 5.44 CC 94.56 rs28688891 0.005 pT3-pT4 84 AA + AG 23.81 GG 76.19 pT1-pT2 147 AA + AG 42.18 GG 57.82 rs12917707 0.003 pT3-pT4 84 AA + AC 19.05 CC 80.95 pT1-pT2 147 AA + AC 38.10 CC 61.90 rs4297685 0.1 pT3-pT4 84 GG 9.52 AG 33.33 AA 57.14 pT1-pT2 147 GG 9.52 AG 46.26 AA 44.22

indicates data missing or illegible when filed

Similarly, as shown in Table 6, rs4293393 as well as 14 SNPs having strong or perfect LD with rs4293393 (r59928757, rs13333226, rs12917707, rs13335818, rs28362063, rs28544423, rs34356953, rs60136849, rs12934320, rs71384446,rs13329952,rs28688991,rs7203642, r512934455) were significantly associated with clinical metastasis, most of them showing a very similar or identical p value, as expected, ranging from 0.005 and 0.03.

Only rs12934455 and rs28640218, even if in LD with rs4293393 with a r²>0.8, were not significantly associated with clinical metastasis, with a p value of 0.06 and 0.1, respectively. However, rs12934455 only marginally failed to meet statistical significance. On the other hand, none of the SNPs having a weak or no LD with rs4293393 were significantly associated with clinical metastasis.

TABLE 6 Association between UMOD SNP variants and presence of clinical metastasis (cM1). Renal mass patients p SNP Variable (n = 276) Genotypic frequencies (%) value rs71384446 0.02 cM1 34 GG + GT 23.53 TT 76.47 cM0 242 GG + GT 43.80 TT 56.20 rs9928757 0.005 cM1 34 GG + CG 14.71 CC 85.29 cM0 242 GG + CG 3

.67 CC

0.33 rs

136849 0.02 cM1 34 GG + GA 14.71 AA 85.29 cM0 242 GG + GA 34.71 AA 65.29 rs11647727 0.3 cM1 34 TT 2.94 CT 35.29 CC 61.76 cM0 242 TT 7.44 CT 42.98 CC 4

.59 rs3435

53 0.02 cM1 34 AA + AC 14.71 CC 85.29 cM0 242 AA + AC 35.12 CC 64.88 rs12934320 0.02 cM1 34 AA + AG 14.71 GG 85.29 cM0 242 AA + AG 35.12 GG 65.70 rs129

4455 0.06 cM1 34 AA + AG 14.71 GG 85.29 cM0 242 AA + AG 30.17 GG 68.83 rs2864

218 0.1 cM1 34 AA + AC 23.53 CC 76.47 cM0 242 AA + AC 37.19 CC 62.81 rs28544423 0.02 cM1 34 AA + AG 14.71 GG 85.29 cM0 242 AA + AG 35.12 GG 64.88 rs13335818 0.02 cM1 34 AA + AG 14.71 GG 85.29 cM0 242 AA + AG 35.12 GG 64.88 rs7193058 0.3 cM1 34 CC 5.88 CT 29.41 TT 64.71 cM0 242 CC 8.26 CT 41.74 TT 50.00 rs76563024 0.9 cM1 34 CC + CT 5.88 TT 94.12 cM0 242 CC + CT 5.37 TT 94.63 rs42

9 0.02 cM1 34 CC + CT 14.71 TT 85.29 cM0 242 CC + CT 35.12 TT 64.88 rs2

3 0.02 cM1 34 GG + AG 14.71 AA 85.29 cM0 242 GG + AG 35.12 AA 64.88 rs13333226 0.01 cM1 34 CC + CT 14.71 TT 85.29 cM0 242 CC + CT 35.95 TT 64.05 rs11862974 0.9 cM1 34 TT + GT 5.88 GG 94.12 cM0 242 TT + GT 6.61 GG 93.39 rs13329952 0.03 cM1 34 GG + AG 20.59 AA 79.41 cM0 242 GG + AG 40.08 AA 58.92 rs720

642 0.03 cM1 34 CC + CT 20.59 TT 79.41 cM0 242 CC + CT 39.67 TT 60.33 rs7204342 0.9 cM1 34 AA + AC 5.88 CC 94.12 cM0 242 AA + AC 6.81 CC 93.39 rs28688991 0.03 cM1 34 AA + AG 20.59 GG 79.41 cM0 242 AA + AG 40.08 GG 59.92 rs12917707 0.2 cM1 34 AA + AC 14.71 CC 85.29 cM0 242 AA + AC 35.12 CC 64.88 rs4297

5 0.7 cM1 34 GG 5.88 AG 41.18 AA 52.94 cM0 242 GG 10.33 AG 42.15 AA 47.52

indicates data missing or illegible when filed

No SNP showed a significant association with high grade (Table 7). However, rs13333226 variant showed a p value of 0.096, on the very limits of significance.

TABLE 7 Association between UMOD SNP variant and higher pathologic grade (G3-G4). RCC patients p SNP Variable (n = 231) Genotypic frequencies (%) value rs71384446 0.5 G3-G4 93 GG + GT 36.56 TT 63.44 G1-G2 138 GG + GT 40.58 TT 59.42 rs9928757 0.3 G3-G4 93 GG + CG 29.03 CC 70.97 G1-G2 138 GG + CG 36.23 CC 63.77 rs60136849 0.2 G3-G4 93 GG + GA 25.81 AA 74.19 G1-G2 138 GG + GA 34.06 AA 65.94 rs11647727 0.3 G3-G4 93 TT 4.30 CT 36.56 CC 59.14 G1-G2 138 TT 5.80 CT 44.93 CC 49.28 rs34356953 0.1 G3-G4 93 AA + AC 25.81 CC 74.19 G1-G2 138 AA + AC 34.78 CC 65.22 rs12934320 0.2 G3-G4 93 AA + AG 25.81 GG 74.19 G1-G2 138 AA + AG 33.33 GG 66.67 rs12934455 0.6 G3-G4 93 AA + AG 24.73 GG 75.27 G1-G2 138 AA + AG 27.54 GG 72.46 rs28640218 0.6 G3-G4 93 AA + AC 31.18 CC 68.82 G1-G2 138 AA + AC 34.06 CC 65.94 rs28544423 0.1 G3-G4 93 AA + AG 25.81 GG 74.19 G1-G2 138 AA + AG 34.78 GG 65.22 rs13335818 0.1 G3-G4 93 AA + A6 25.81 GG 74.19 G1-G2 138 AA + AG 34.78 GG 65.22 rs7193058 0.2 G3-G4 93 CC 5.38 CT 33.33 TT 61.29 G1-G2 138 CC 6.52 CT 44.20 TT 49.28 rs76563024 0.8 G3-G4 93 CC + CT 4.30 TT 95.70 G1-G2 138 CC + CT 3.62 TT 96.38 rs4293393 0.1 G3-G4 93 CC + CT 25.81 TT 74.19 G1-G2 138 CC + CT 34.78 TT 65.22 rs28362063 0.1 G3-G4 93 GG + AG 25.81 AA 74.19 G1-G2 138 GG + AG 34.78 AA 65.22 rs13333226 0.096 G3-G4 93 CC + CT 25.81 TT 74.19 G1-G2 138 CC + CT 36.23 TT 63.77 rs11862974 0.9 G3-G4 93 TT + GT 5.38 GG 94.62 G1-G2 138 TT + GT 5.07 GG 94.93 rs13329952 0.3 G3-G4 93 GG + AG 31.18 AA 68.82 G1-G2 138 GG + AG 38.41 AA 61.59 rs7203642 0.3 G3-G4 93 CC + CT 31.18 TT 68.82 G1-G2 138 CC + CT 37.68 TT 62.32 rs7204342 0.9 G3-G4 93 AA + AC 5.38 CC 94.62 G1-G2 138 AA + AC 5.07 CC 94.93 rs28688991 0.3 G3-G4 93 AA + AG 31.18 GG 68.82 G1-G2 138 AA + AG 38.41 GG 61.59 rs12917707 0.1 G3-G4 93 AA + AC 25.81 CC 74.19 G1-G2 138 AA + AC 34.78 CC 65.22 rs429768S 0.8 G3-G4 93 GG 10.75 AG 41.94 AA 47.31 G1-G2 138 GG 8.70 AG 4130 AA 50.00

As shown in Table 8, there are 7 SNPs, rs76563024, rs9928757, rs7193058, rs11862974, rs7204342, rs28640218, and rs11647727, which showed a statistically significant association with patients with a malignant lesion (kidney cancer), with respect to patients with a benign mass. rs76563024, rs11862974, and rs7204342 were in strong LD among each other, as well as rs7193058 was in strong LD with rs11647727, as shown in FIG. 1 .

On the other hand, rs71384446, rs7203642, rs13329952, rs28688991, showed a similar association with malignant histotypes with a p value between 0.07 and 0.09 (Table 8). This suggest a trend for association that could become significant by increasing the study cohort.

TABLE 8 Association between UMOD SNP variants and risk of RCC. Renal mass patients p SNP Variable (n = 276) Genotypic frequencies (%) value rs71384446 0.07 Malignant lesion 231 GT + GG 38.96 TT 61.04 Benign mass 45 GT + GG 53.33 TT 46.67 rs9928757 0.01 Malignant lesion 231 CG + GG 33.33 CC 66.67 Benign mass 45 CG + GG 53.33 CC 46.67 rs

0.2 Malignant lesion 231 GA + GG 30.74 AA 6

.26 Benign mass 45 GA + GG 40.00 AA 60.00 rs11647727 0.03 Malignant lesion 231 TT 5.19 CT 41.56 CC 53.25 Benign mass 45 TT 15.56 CT 4.44 CC 40.00 rs34356953 0.2 Malignant lesion 231 AC + AA 31.17 CC 68.83 Benign mass 45 AC + AA 40.00 CC 80.00 rs12934320 0.2 Malignant lesion 231 AG + AA 30.30 GG 69.70 Benign mass 45 AG + AA 40.00 GG 60.00 rs12934455 0.1 Malignant lesion 231 AG + AA 26.41 GG 73.58 Benign mass 45 AG + AA 37.78 GG 62.22 rs28640218 0.04 Malignant lesion 231 AC + AA 32.90 CC 67.10 Benign mass 45 AC + AA 48.89 CC 51.11 rs28544423 0.2 Malignant lesion 231 AG + AA 31.17 GG

8.83 Benign mass 45 AG + AA 40.00 GG 60.00 rs13335818 0.2 Malignant lesion 231 AG + AA 31.17 GG 68.83 Benign mass 45 AG + AA 40.00 GG 60.00 rs7193058 0.02 Malignant lesion 231 CC 6.06 CT 3

.83 TT 54.11 Benign mass 45 CC 17.78 CT 42.22 TT 40.00 rs76563024 0.01 Malignant lesion 231 CT + CC 3.90 TT 96.10 Benign mass 45 CT + CC 13.33 TT 86.67 rs4293393 0.2 Malignant lesion 231 CT + CC 31.17 TT 68.83 Benign mass 45 CT + CC 40.00 TT 60.00 rs28362053 0.2 Malignant lesion 231 AG + GG 31.17 AA 68.83 Benign mass 45 AG + GG 40.00 AA 60.00 rs13333226 0.3 Malignant lesion 231 CT + CC 32.03 TT 67.97 Benign mass 45 CT + CC 40.00 TT 60.00 rs11862974 0.04 Malignant lesion 231 GT + TT 5.19 GG 94.81 Benign mass 45 GT + TT 13.33 GG 86.67 rs13329952 0.09 Malignant lesion 231 AG + GG 35.50 AA 64.50 Benign mass 45 AG + GG 48.89 AA 51.11 rs7204342 0.08 Malignant lesion 231 CT + CC 35.06 TT 64.94 Benign mass 45 CT + CC 48.89 TT 51.11 rs7204342 0.04 Malignant lesion 231 AC + AA 5.19 CC 94.81 Benign mass 45 AC + AA 13.33 CC 86.67 rs28688991 0.09 Malignant lesion 231 AG + AA 35.50 GG 64.50 Benign mass 45 AG + AA 48.89 GG 51.11 rs12917707 0.2 Malignant lesion 231 AC + AA 31.17 CC 68.83 Benign mass 45 AC + AA 40.00 CC 60.00 rs4297685 0.8 Malignant lesion 231 GG 9.52 AG 41.56 AA 48.92 Benign mass 45 GG 11.11 AG 44.44 AA 44.44

indicates data missing or illegible when filed

As showed in Table 9, rs7193058 and rs11647727 variants showed a statistically significant association with renal mass patients with respect to controls, with a p value of 0.03 and 0.04, respectively. Of note, most of the controls are patients with kidney stones and it is known that some UMOD variants, especially those located in the UMOD gene promoter, are associated with reduced risk of kidney stones [Gudbjartsson et al., 2010]. Since the UMOD promoter top variant rs4293393 shows a higher p value of 0.2, the inventors believe that the association of rs11647727 and rs7193058 variants is not driven by an enrichment of renal lithiasis-related variants in the control population.

TABLE 9 Association between UMOD SNP variants and risk of renal mass. Overall population p SNP Variable (n =

) Genotypic frequencies (%) value rs

0.4 Renal mass patients 276 GT + GG 41.30 TT 58.70 Controls 83 GT + GG 4#z,899.99 TT

rs

0.5 Renal mass patients 276 CG + GG

CC 65.41 Controls 83 CG + GG 40.95 CC 5

.04 rs

0.1 Renal mass patients 276 GA + GG 32.25 AA 67.75 Controls 83 GA + GG 40.96 AA 5

.04 rs

0.04 Renal mass patients 276 TT

CT 42.03 CC 51.09 Controls 83 TT

.02 CT 57.83 CC 36.14 rs

0.2 Renal mass patients 276 AC + AA 32.61 CC 67.39 Controls 83 AC + AA 40.

CC 5

.04 rs

0.1 Renal mass patients 276 AG + AA 31.88 GG 68.12 Controls 83 AG + AA 40.95 GG 59.04 rs

0.5 Renal mass patients 276 AG + AA 28.25 GG 71.74 Controls 83 AG + AA

.55 GG 57.47 rs

0.2 Renal mass patients 276 AC + AA 35.51 CC

4.49 Controls 83 AC + AA 43.37 CC

rs

0.2 Renal mass patients 276 AG + AA 37.61 GG 67.39 Controls 83 AG + AA 40.96 GG 59.04 rs

0.2 Renal mass patients 276 AG + AA 32.61 GG 87.38 Controls 83 AG + AA 39.76 GG 60.24 rs

0.03 Renal mass patients 276 CC 7.97 CT 40.22 TT 51.81 Controls 83 CC 5.02 CT 56.63 TT 37.35 rs

0.5 Renal mass patients 276 CT + CC 5.43 TT 94.57 Controls 83 CT + CC 7.23 TT 92.77 rs

0.2 Renal mass patients 276 CT + CC

TT 67.39 Controls 83 CT + CC 42.95 TT 59.04 rs

0.2 Renal mass patients 276 AG + GG 32.61 AA 67.39 Controls 83 AG + GG 39.76 AA 50.24 rs

0.1 Renal mass patients 276 CT + CC 33.33 TT 56.67 Controls 83 CT + CC 42.17 TT 57.83 rs

0.3 Renal mass patients 276 GT + TT 6.52 GG 95.48 Controls 83 GT + TT 8.43 GG

rs

0.3 Renal mass patients 276 AG + GG 37.68 AA 62.32 Controls 83 AG + GG 44.58 AA 55.42 rs7208642 0.2 Renal mass patients 276 CT + CC 57.32 TT 62.68 Controls 83 CT + CC 45.78 TT 55.42 rs7204342 0.3 Renal mass patients 276 AC + AA 6.52 CC

Controls 83 AC + AA 9.64 CC 90.56 rs

0.2 Renal mass patients 276 AG + AA 37.68 GG

.32 Controls 83 AG + AA 45.78 GG

.22 rs12917707 0.2 Renal mass patients 276 AC + AA 32.61 CC 67.39 Controls 83 AC + AA 39.76 CC 60.24 rs4297685 0.4 Renal mass patients 276 GG 9.78 AG 42.05 AA 48.19 Controls 83 GG 4.82 AG 43.37 AA

indicates data missing or illegible when filed

Example 2: Circulating Plasma miRNAs Profiling in the Total Study Population

To develop specific miRNA signatures for RCC screening, diagnosis, and prognosis, a TaqMan-based high-throughput screen of 668 miRNAs was performed in plasma samples of 120 patients with a renal mass (either benign or malignant) and 78 controls.

MiRNAs previously described as readily detectable in human plasma samples—including hsa-miR-16-5p, and hsa-miR-21-3p—were detected in all samples. Following the inventors' filtering criteria, a total of 273 miRNAs were subjected to differential expression analyses. The inventors found a set of 54 miRNAs that was significantly differentially expressed (p value <0.05) in plasma of patients with a renal mass (n=115) compared with controls (n=78). In addition, 18 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (0.05<p value <0.1) (Table 10).

TABLE 10 Differentially expressed miRNAs in patients with a renal mass (n = 115) compared with controls (n = 78). miRNA FC* p value hsa-miR-423-5p 1.28 0.0001 hsa-miR-186-5p 1.18 0.0002 hsa-miR-877-5p 1.46 0.0004 hsa-miR-378a-3p 1.28 0.0004 hsa-miR-320e 1.27 0.001 hsa-miR-652-3p 1.26 0.001 hsa-miR-598-3p 1.19 0.002 hsa-miR-197-3p 0.65 0.002 hsa-miR-500a-5p 1.39 0.003 hsa-miR-205-5p 0.71 0.003 hsa-miR-6803-3p 0.73 0.003 hsa-miR-125a-5p 0.86 0.003 hsa-miR-320a-3p 1.18 0.006 hsa-let-7e-5p 0.87 0.007 hsa-miR-362-5p 1.28 0.007 hsa-miR-21-5p 1.14 0.008 hsa-miR-132-3p 0.79 0.008 hsa-miR-375-3p 0.71 0.009 hsa-miR-1260a 0.73 0.01 hsa-miR-331-3p 0.85 0.01 hsa-miR-128-3p 1.12 0.01 hsa-miR-532-5p 1.23 0.01 hsa-miR-29c-5p 1.16 0.01 hsa-miR-378a-5p 0.82 0.01 hsa-miR-28-3p 1.24 0.01 hsa-miR-145-5p 0.85 0.01 hsa-miR-151b 0.91 0.01 hsa-miR-361-5p 1.22 0.02 hsa-miR-501-5p 1.26 0.02 hsa-miR-369-3p 0.84 0.02 hsa-miR-4286 0.89 0.02 hsa-miR-505-3p 1.15 0.02 hsa-miR-10a-5p 0.86 0.02 hsa-miR-2110 1.24 0.02 hsa-miR-193b-3p 0.83 0.02 hsa-miR-224-5p 0.80 0.02 hsa-miR-214-3p 0.77 0.02 hsa-miR-181a-5p 1.28 0.02 hsa-miR-628-3p 0.76 0.02 hsa-miR-550a-3-5p 1.57 0.03 hsa-miR-339-3p 1.18 0.03 hsa-miR-323a-3p 1.41 0.03 hsa-miR-500a-3p 1.15 0.03 hsa-miR-125b-5p 0.84 0.03 hsa-miR-483-3p 0.81 0.03 hsa-miR-151a-3p 1.20 0.04 hsa-miR-499a-5p 1.29 0.04 hsa-miR-21-3p 1.15 0.04 hsa-miR-3940-3p 0.89 0.04 hsa-miR-10b-5p 0.75 0.04 hsa-miR-769-5p 1.26 0.04 hsa-miR-30d-5p 1.09 0.04 hsa-miR-181b-5p 1.16 0.04 hsa-miR-448 0.83 0.049 hsa-miR-377-3p 0.86 0.05 hsa-miR-4306 1.16 0.05 hsa-miR-22-5p 1.08 0.05 hsa-miR-380-3p 0.84 0.05 hsa-miR-103a-2-5p 0.91 0.06 hsa-miR-130b-5p 0.81 0.06 hsa-miR-146a-5p 1.19 0.06 hsa-miR-188-5p 1.18 0.06 hsa-miR-210-3p 1.13 0.07 hsa-miR-885-5p 0.68 0.07 hsa-miR-320b 1.12 0.07 hsa-miR-26b-3p 0.88 0.07 hsa-miR-421 0.89 0.08 hsa-miR-7-5p 0.85 0.08 hsa-miR-579-3p 0.78 0.08 hsa-miR-17-3p 1.08 0.08 hsa-miR-24-3p 1.16 0.09 hsa-miR-660-5p 1.18 0.09 *FC: fold changes (>1 increased; <1 decreased expression in in patients with a renal mass)

Then, the inventors investigated whether patients with a benign mass were associated with a specific miRNA signature that significantly differs (p value <0.05) from patients with a malignant lesion (RCC). The inventors observed 6 miRNAs significantly differentially expressed in patients with a benign mass (n=24) compared with RCC patients (n=91). In addition, 12 miRNAs showed a trend towards statistical significance (0.05<p value <0.1) (Table 11).

TABLE 11 Differentially expressed miRNAs in patients with a benign mass (n = 24) compared with RCC patients (n = 91). miRNA FC* p value* hsa-miR-337-5p 1.23 0.01 hsa-miR-99a-3p 1.68 0.02 hsa-miR-331-5p 1.52 0.02 hsa-miR-221-5p 1.26 0.03 hsa-miR-1290 1.35 0.04 hsa-miR-196b-5p 1.36 0.048 hsa-miR-550a-3-5p 1.49 0.06 hsa-miR-548l 1.35 0.06 hsa-miR-152-3p 1.09 0.06 hsa-miR-501-5p 1.23 0.06 hsa-miR-125b-5p 0.79 0.08 hsa-miR-34a-3p 0.60 0.08 hsa-miR-410-3p 1.28 0.08 hsa-miR-485-3p 0.59 0.08 hsa-miR-192-5p 0.80 0.08 hsa-miR-361-3p 0.85 0.098 hsa-miR-877-5p 1.16 0.098 hsa-miR-215-5p 0.79 0.099 *fold changes (>1 increased; <1 decreased expression in RCC patients)

The inventors also analyzed whether specific miRNA expression patterns were correlated to established predictors of RCC prognosis that are direct markers of clinical aggressiveness, namely tumour stage, tumour grade, and presence of clinical metastasis (cM1).

A panel of 43miRNAs was found to be significantly differentially expressed between low grade RCC patients (n=64) and high grade cases (27). 36 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (Table 12).

TABLE 12 Differentially expressed miRNAs (p value ≤ 0.05) in low grade RCC patients (n = 64) compared with high grade RCC patients (n = 27). miRNA FC* p value hsa-miR-382-5p 2.50 0.0004 hsa-miR-18a-5p 0.73 0.0006 hsa-miR-125b-5p 0.57 0.0009 hsa-miR-20a-5p 0.71 0.002 hsa-miR-429 0.55 0.002 hsa-miR-17-5p 0.70 0.002 hsa-miR-369-3p 1.41 0.002 hsa-miR-21-3p 1.44 0.002 hsa-miR-382-3p 1.80 0.003 hsa-miR-134-5p 1.81 0.004 hsa-miR-433-3p 1.81 0.004 hsa-miR-100-5p 0.50 0.005 hsa-miR-125a-5p 0.79 0.006 hsa-miR-584-5p 1.24 0.006 hsa-miR-93-5p 0.79 0.006 hsa-miR-20b-5p 0.77 0.007 hsa-miR-18a-3p 0.80 0.008 hsa-miR-374a-3p 0.64 0.009 hsa-miR-410-3p 1.42 0.01 hsa-let-7b-5p 0.71 0.01 hsa-miR-424-3p 1.43 0.01 hsa-miR-101-3p 0.69 0.01 hsa-miR-32-3p 1.19 0.02 hsa-miR-154-5p 1.87 0.02 hsa-miR-409-3p 2.18 0.02 hsa-miR-130b-3p 1.10 0.02 hsa-miR-193b-3p 0.66 0.02 hsa-miR-484 0.80 0.02 hsa-miR-3613-3p 0.81 0.02 hsa-miR-629-5p 1.35 0.02 hsa-miR-151a-3p 1.25 0.02 hsa-miR-493-5p 1.67 0.02 hsa-let-7d-3p 1.15 0.03 hsa-miR-144-3p 0.59 0.03 hsa-miR-885-5p 0.54 0.03 hsa-miR-655-3p 1.32 0.03 hsa-miR-106b-3p 0.85 0.03 hsa-miR-942-5p 1.23 0.04 hsa-miR-374a-5p 0.72 0.04 hsa-miR-148a-3p 0.83 0.04 hsa-let-7e-3p 0.74 0.04 hsa-miR-127-3p 1.79 0.04 hsa-miR-103a-3p 0.77 0.046 hsa-miR-323b-3p 1.79 0.05 hsa-miR-337-5p 1.18 0.05 hsa-miR-376c-3p 1.54 0.05 hsa-miR-195-5p 0.83 0.06 hsa-miR-181a-3p 1.17 0.06 hsa-miR-483-5p 1.54 0.06 hsa-miR-590-3p 0.85 0.06 hsa-let-7d-5p 0.68 0.06 hsa-miR-151a-5p 1.22 0.06 hsa-miR-324-5p 0.83 0.06 hsa-miR-500a-5p 0.70 0.06 hsa-miR-331-3p 0.84 0.06 hsa-miR-7-l-3p 1.18 0.06 hsa-miR-154-3p 1.21 0.06 hsa-miR-10a-5p 0.78 0.07 hsa-miR-194-5p 0.71 0.07 hsa-miR-22-5p 1.11 0.07 hsa-miR-423-5p 1.25 0.07 hsa-miR-142-3p 0.79 0.07 hsa-miR-30b-5p 0.85 0.07 hsa-miR-548a-3p 1.32 0.07 hsa-miR-1537-3p 1.17 0.07 hsa-miR-221-3p 1.19 0.07 hsa-miR-495-3p 1.66 0.07 hsa-miR-1290 1.44 0.08 hsa-miR-455-3p 0.64 0.08 hsa-miR-377-3p 1.30 0.08 hsa-miR-451a 0.70 0.08 hsa-miR-16-5p 0.78 0.08 hsa-miR-301a-3p 0.81 0.08 hsa-miR-376a-3p 1.43 0.09 hsa-miR-122-5p 0.57 0.09 hsa-miR-1301-3p 1.12 0.09 hsa-miR-374b-5p 0.81 0.09 hsa-let-7g-5p 0.83 0.098 hsa-miR-144-5p 0.74 0.098 *fold changes (>1 increased; <1 decreased expression in high grade RCC patients)

Similarly, the inventors found that 38 miRNAs can significantly distinguish (p value <0.05) between low stage RCC patients (n=65) and high stage RCC patients (n=26), while 20 miRNAs showed a trend towards statistical significance (0.05<p value <0.1)(Table 13).

TABLE 13 Differentially expressed miRNAs in low stage RCC patients (n = 65) compared with high stage RCC patients (n = 26). miRNA FC* p value hsa-miR-629-5p 1.55 0.0004 hsa-miR-320a-3p 1.38 0.001 hsa-miR-423-5p 1.43 0.002 hsa-miR-30b-5p 0.78 0.002 hsa-miR-320e 1.44 0.003 hsa-miR-374a-5p 0.67 0.004 hsa-miR-100-5p 0.47 0.005 hsa-miR-374a-3p 0.60 0.006 hsa-miR-30c-5p 0.81 0.007 hsa-miR-2110 1.37 0.007 hsa-miR-27b-3p 0.74 0.008 hsa-miR-664a-3p 0.69 0.008 hsa-let-7d-3p 1.17 0.01 hsa-miR-548k 1.29 0.01 hsa-miR-26b-5p 0.75 0.01 hsa-miR-374b-5p 0.76 0.01 hsa-miR-483-5p 1.71 0.01 hsa-miR-378a-3p 1.31 0.01 hsa-miR-769-5p 1.54 0.02 hsa-miR-34a-3p 1.72 0.02 hsa-miR-125a-5p 0.83 0.02 hsa-miR-224-5p 0.70 0.02 hsa-miR-320b 1.29 0.02 hsa-miR-27a-3p 0.77 0.02 hsa-miR-545-3p 0.79 0.02 hsa-miR-335-5p 0.84 0.03 hsa-miR-140-3p 1.21 0.03 hsa-miR-126-3p 0.82 0.03 hsa-miR-382-5p 1.77 0.03 hsa-miR-484 0.81 0.03 hsa-miR-18a-5p 0.85 0.03 hsa-miR-29c-3p 1.09 0.04 hsa-miR-26a-5p 0.74 0.04 hsa-miR-339-3p 1.33 0.04 hsa-miR-202-5p 1.38 0.04 hsa-miR-133b 0.55 0.045 hsa-miR-590-3p 0.83 0.048 hsa-miR-15a-3p 0.83 0.049 hsa-miR-324-3p 0.87 0.05 hsa-miR-628-3p 1.28 0.06 hsa-miR-17-5p 0.80 0.06 hsa-miR-1290 1.33 0.06 hsa-miR-502-3p 1.26 0.07 hsa-miR-424-3p 1.28 0.07 hsa-miR-301a-3p 0.83 0.07 hsa-miR-139-5p 0.80 0.08 hsa-miR-148b-3p 0.88 0.08 hsa-miR-142-3p 0.78 0.08 hsa-miR-133a-3p 0.73 0.08 hsa-miR-20a-5p 0.83 0.08 hsa-miR-942-5p 1.19 0.08 hsa-miR-190a-5p 0.85 0.09 hsa-miR-1307-5p 0.73 0.09 hsa-miR-885-5p 0.64 0.09 hsa-miR-1180-3p 1.59 0.09 hsa-miR-29c-5p 1.10 0.09 hsa-miR-4306 1.30 0.09 hsa-miR-1249-3p 0.77 0.098 *fold changes (>1 increased; <1 decreased expression in high stage RCC patients)

Finally, 15 miRNAs were found to be significantly differentially expressed between cM0 RCC patients (n=84) and cM1 RCC patients (n=7), while 21 miRNAs show a p value between 0.05 and 0.098, indicating a trend towards statistical significance (Table 14).

TABLE 14 Differentially expressed miRNAs in cM0 RCC patients (n = 84) compared with cM1 RCC patients (n = 7). miRNA FC* p value hsa-miR-337-5p 1.44 0.006 hsa-miR-410-3p 1.72 0.008 hsa-miR-374a-3p 0.52 0.01 hsa-miR-590-3p 0.71 0.01 hsa-miR-377-3p 1.92 0.02 hsa-miR-548k 1.49 0.02 hsa-miR-382-5p 2.68 0.03 hsa-miR-655-3p 1.49 0.03 hsa-miR-378a-5p 1.50 0.03 hsa-let-7d-3p 1.19 0.04 hsa-miR-1290 2.05 0.04 hsa-miR-483-5p 1.75 0.04 hsa-miR-323b-3p 2.76 0.047 hsa-miR-376c-3p 2.00 0.048 hsa-miR-590-5p 0.75 0.048 hsa-miR-374a-5p 0.57 0.05 hsa-let-7g-3p 0.67 0.05 hsa-miR-18a-5p 0.81 0.06 hsa-miR-142-3p 0.66 0.06 hsa-miR-125a-5p 0.79 0.07 hsa-miR-130b-3p 1.22 0.07 hsa-miR-429 0.53 0.07 hsa-miR-15a-3p 0.73 0.08 hsa-miR-20a-5p 0.72 0.08 hsa-miR-134-5p 1.67 0.08 hsa-miR-369-3p 1.31 0.08 hsa-miR-548l 1.61 0.08 hsa-miR-127-3p 2.18 0.08 hsa-miR-196b-5p 1.41 0.08 hsa-miR-877-5p 1.60 0.08 hsa-miR-671-5p 1.47 0.09 hsa-miR-17-5p 0.75 0.09 hsa-miR-532-3p 0.76 0.09 hsa-miR-409-3p 2.40 0.09 hsa-miR-484 0.78 0.09 hsa-miR-376a-3p 1.81 0.098 *fold changes (>1 increased; <1 decreased expression in cM1 RCC patients)

Since in most cases it is very difficult to reach high accuracy, specificity and sensitivity for discrimination between two clinical conditions (i.e. renal mass patients vs controls, patients with a benign mass vs patients with a malignant lesion, patients with high grade RCC vs patients with low grade RCC, patients with high stage RCC vs patients with low stage RCC, patients with clinical metastasis (cM1) vs patients without clinical metastasis (cM0)) using a single miRNA biomarker, no simple threshold method can be used. Therefore, in addition to single biomarker analysis, the inventors identified unique sets of miRNAs (miRNA signatures), leading to a significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms.

The inventors investigated also clinical parameters in association with miRNAs biomarkers, using the feature selection algorithm, and the variable age resulted predictive in association with some miRNAs in screening, and clinical metastasis.

It is important to underline that the single variable age, using the same evaluation metric, performed significantly less than the presented combinations with an accuracy of 52.10%, recall of 48.69%, and ROC AUC of 54.13% for screening and an accuracy of 74.44%, recall of 20%, and ROC AUC of 22.78% for clinical metastasis.

In addition, the inventors combined some of the identified miRNAs signatures (together or not with age) with SNPs, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms (Table 15, 16, 17, 18, 19).

This is the list of the best 29 mRNAs selected by the algorithm sorted by importance for screening outcome: hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-28-3p, hsa-miR-15b, 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5, hsa-miR-423-5p, hsa-miR-29a-3p, and hsa-miR-7-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening (Table 15).

TABLE 15 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for screening. N Combinations Accuracy ROC AUC Recall 1 hsa-miR-197-3p 63.42 63.58 86.89 2 hsa-miR-197-3p, hsa-miR-378a-3p 67.53 71.47 84.24 3 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136 68.58 72.54 81.74 4 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 72.29 78.01 82.5 28-3p 5 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 75.42 78.52 81.67 28-3p, hsa-miR-15b-3p 6 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 74.37 78.5 80.0 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p 7 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 75.95 80.29 83.41 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p 8 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 73.87 79.82 81.67 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p 9 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 75.97 80.63 84.32 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age 10 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 74.89 81.16 84.32 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p 11 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 76.5 80.78 85.15 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p 12 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 74.95 81.94 83.33 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326 13 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 74.39 80.91 83.41 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p 14 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 75.95 82.08 81.67 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p 15 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 75.95 81.96 80.83 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p 16 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 77.00 84.11 84.24 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p 17 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 76.47 83.69 83.33 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b 18 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 79.61 84.79 83.33 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306 19 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 82.24 85.88 83.41 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p 20 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.16 85.09 81.67 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p 21 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.16 85.21 85.15 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p 22 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.18 85.55 85.15 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p 23 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.18 85.70 82.65 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p 24 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 82.21 86.38 82.65 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p 25 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.71 88.13 84.32 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p 26 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.71 88.26 84.32 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p 27 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 81.71 87.57 85.15 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p 28 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 80.11 87.19 83.41 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-423-5p 29 hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR- 80.16 87.40 86.97 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p 30 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 81.76 85.90 86.06 3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR- 423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, 31 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 81.74 85.94 86.21 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa- miR-323b-3p, 32 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 81.71 85.52 84.39 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 33 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 81.18 83.44 83.64 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b- 3p, 34 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 80.68 83.34 81.89 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 35 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 80.68 84.57 83.56 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 36 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 80.68 85.08 85.3 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 37 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 80.68 84.63 85.3 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 38 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 80.68 85.56 82.8 3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR- 423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 39 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 80.68 84.00 85.38 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 40 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 80.68 85.17 84.47 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR- 323b-3p, 41 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 80.66 86.09 82.73 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 42 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 80.66 84.60 82.58 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803- 3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa- miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 43 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 80.66 84.33 87.05 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 44 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 80.66 85.02 83.64 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 45 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 80.66 86.31 82.8 4306, hsa-miR-1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 46 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 80.63 85.41 86.14 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 47 hsa-miR-326, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195- 80.63 84.69 85.38 5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa- miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 48 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 80.18 85.15 81.89 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 49 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p, 80.16 86.05 84.55 hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 50 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 80.16 85.47 81.89 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 51 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21- 80.16 81.61 82.58 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 52 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 80.13 84.73 83.48 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 53 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21- 80.13 84.75 84.47 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR- 550a-3-5p, age, hsa-miR-323b-3p, 54 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 80.13 82.8 85.3 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 55 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 80.13 84.05 81.74 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 56 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 80.13 83.98 85.3 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 57 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 80.13 84.72 84.39 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, 58 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 80.13 85.77 83.56 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, 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hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 79 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 79.63 84.19 83.48 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa- miR-323b-3p, 80 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 79.61 83.47 84.39 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 81 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 79.61 83.84 84.39 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-28-3p, 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hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, hsa-miR-323b-3p, 86 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 79.61 84.89 83.56 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 87 hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 79.61 84.46 85.38 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 88 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 79.58 83.01 84.55 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, 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82.77 81.89 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 93 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 79.13 84.56 84.55 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 94 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.13 85.02 85.3 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 95 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.13 84.27 83.56 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, 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hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa- miR-323b-3p, 106 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.08 85.14 83.56 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 107 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 79.08 83.49 84.55 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 108 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.08 85.37 84.39 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3- 5p, age, hsa-miR-323b-3p, 109 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hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 113 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 79.08 81.09 83.56 21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 114 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.08 84.61 86.06 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 115 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 79.08 83.48 82.88 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 116 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 79.08 83.31 83.71 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 117 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 79.08 84.69 82.65 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 118 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 79.08 82.03 82.65 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 119 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 79.08 83.1 84.32 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 120 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 79.08 84.6 81.74 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 121 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 79.08 80.71 83.64 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, age, hsa-miR-323b-3p, 122 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 79.05 84.67 83.48 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 123 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 79.05 84.18 86.06 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b- 3p, 124 hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 79.05 84.75 82.73 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 125 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 79.05 82.92 85.15 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 126 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.63 83.14 81.06 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, 127 hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.63 83.52 80.98 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 128 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 78.61 85.42 83.56 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 129 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 78.61 83.65 82.65 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 130 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.61 83.28 84.55 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 131 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.61 86.04 84.62 hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 132 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 78.61 84.62 83.48 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 133 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.61 86.2 82.8 hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 134 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.61 85.22 82.8 hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 135 hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 78.61 84.25 81.89 1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 136 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 78.61 84.27 83.48 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 137 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.58 82.64 84.47 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, 138 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 78.58 86.71 83.56 3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR- 423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 139 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 78.58 83.41 83.64 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 140 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 78.58 86 82.58 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, hsa-miR-323b-3p, 141 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a- 78.58 84.13 81.06 5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p, 142 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.58 84.42 80.83 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 143 hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-21-5p, hsa-miR-377- 78.58 81.07 85.98 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa- miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 144 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.58 84.58 81.89 4306, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa- miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 145 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 78.58 82.71 81.97 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-374a- 5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 146 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 78.58 84.47 83.56 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 147 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.58 85.35 83.64 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 148 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.58 83.55 80.83 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 149 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 78.55 84.62 82.73 1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 150 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.55 84.55 83.56 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 151 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, 78.55 85.2 83.56 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 152 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 78.55 86.36 82.73 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 153 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 78.55 85.55 82.8 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423- 5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 154 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 78.55 85.3 83.64 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 155 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.55 84.2 83.56 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR- 550a-3-5p, age, hsa-miR-323b-3p, 156 hsa-miR-326, hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR- 78.55 84.2 83.41 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423- 5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 157 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 78.55 82.4 81.82 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, 158 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 78.11 83 81.89 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, 159 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 78.11 81.18 84.7 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, hsa-miR-323b-3p, 160 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.11 84.64 82.73 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, 161 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.11 83.96 82.8 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 162 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 78.11 83.02 81.74 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3- 5p, hsa-miR-323b-3p, 163 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.08 84.56 81.89 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 164 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.08 85.91 83.64 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 165 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 78.08 85.23 82.88 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 166 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.08 82.82 83.56 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 167 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p, 78.08 85.99 81.89 hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, 168 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.08 81.83 81.74 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 169 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.08 83.22 83.56 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423- 5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, 170 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.08 84.46 81.89 hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 171 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 78.08 84.22 83.64 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 172 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 78.08 84.94 80.08 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 173 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21- 78.05 85.03 81.89 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa- miR-323b-3p, 174 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.05 84.83 82.8 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 175 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 78.05 84.14 83.71 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 176 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 78.05 82.7 84.47 377-3p, hsa-miR-483-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, 177 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 78.05 85.44 80.98 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p, 178 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.05 84.96 83.56 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 179 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.05 84.97 84.55 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 180 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 78.05 84.83 80.15 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803- 3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, hsa-miR-323b-3p, 181 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 78.05 85.93 82.73 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 182 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21- 78.05 83.66 80.76 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 183 hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 78.05 83.56 81.82 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 184 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.05 85.64 80.83 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 185 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 78.05 84.2 82.65 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 186 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 78.03 84.38 82.73 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR- 550a-3-5p, age, hsa-miR-323b-3p, 187 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-5p, 78.03 84.61 80.98 hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR- 181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 188 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 78.03 81.71 82.65 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 189 hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 78.03 85.03 80.76 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 190 hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, 78.03 85.73 79.17 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 191 hsa-miR-326, hsa-miR-142-5p, hsa-miR-4306, hsa-miR-1301- 78.03 82.66 82.58 3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 192 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 78.03 81.43 81.74 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, 193 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-377- 77.58 80.76 82.58 3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa- miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR- 323b-3p, 194 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195- 77.58 79.56 81.97 5p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 195 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 77.58 81.72 80.83 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa- miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 196 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21- 77.58 85.14 82.73 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 197 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.58 83.11 80.98 1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, age, 198 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 77.58 84.61 82.73 1260b, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR- 423-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 199 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.55 85 81.89 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, 200 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 77.55 83.38 82.73 3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa- miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR- 323b-3p, 201 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 77.55 81.7 81.89 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 202 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 77.55 84.81 80.98 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 203 hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, 77.55 85.01 81.82 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 204 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 77.55 84.94 85.23 130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa- miR-323b-3p, 205 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.55 83.36 80.98 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 206 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 77.55 84.67 80.91 4306, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR- 323b-3p, 207 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 77.55 81.54 79.92 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 208 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 77.55 84.74 80.23 3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa- miR-181c-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, 209 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 77.53 81.83 84.32 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 210 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a- 77.53 85.09 81.67 5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa- miR-323a-3p, age, hsa-miR-323b-3p, 211 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 77.53 82.44 82.8 3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, age, 212 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 77.53 82.71 79.24 1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 213 hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.5 84.91 80.76 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa- miR-323b-3p, 214 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 77.5 83.41 83.64 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, 215 hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 77.5 82.7 82.73 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 216 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 77.5 83.3 82.65 4306, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 217 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 77.5 83.51 81.82 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803- 3p, hsa-miR-101-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 218 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 77.5 86.62 80.98 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 219 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR- 77.5 82.39 82.73 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 220 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.5 84.6 81.67 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 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hsa-miR-483-5p, hsa-miR-181c-3p, hsa- miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 225 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 77.05 84.49 82.65 130a-3p, hsa-miR-1260b, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, 226 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 77.05 82.85 80.91 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, age, 227 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 77.05 82.19 81.82 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 228 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.05 84.64 80.15 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 229 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 77.03 82.41 82.65 3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, 230 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 77.03 83.45 80.15 1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 231 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 77.03 82.72 82.5 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, 232 hsa-miR-326, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-4306, 77.03 83.56 81.89 hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 233 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 77.03 84.13 81.06 hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 234 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 77.03 82.35 80.91 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa- miR-323a-3p, age, 235 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 77.03 78.58 79.02 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 236 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 77.03 82.22 81.89 hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a- 3p, age, hsa-miR-323b-3p, 237 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 77.03 82.8 81.82 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, age, hsa- miR-323b-3p, 238 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 77.03 84.3 80.98 21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 239 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 77.03 84.79 81.74 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 240 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 77.00 83.30 82.65 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 241 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 77.00 82.07 81.67 1260b, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa- miR-323b-3p, 242 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 76.97 83.16 84.39 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 243 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, 76.97 84.41 80.83 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 244 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 76.97 84.74 81.06 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a- 3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 245 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 76.97 84.57 82.65 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 246 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b- 76.97 81.69 84.17 3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423- 5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, 247 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 76.95 84.4 79.92 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 248 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, 76.95 85.22 82.73 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, age, 249 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 76.55 84.65 80.15 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa- miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 250 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 76.53 85.34 81.82 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 251 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR- 76.53 82.56 81.59 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 252 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b- 76.53 82.83 81.97 3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, 253 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 76.53 83.43 79.32 1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR- 15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p, 254 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 76.5 85.53 81.21 3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 255 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 76.5 83.58 83.56 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa- miR-323b-3p, 256 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 76.5 82.09 81.74 21-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 257 hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 76.5 83.47 82.8 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 258 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 76.5 82.57 81.89 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, 259 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 76.47 82.33 83.56 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 260 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-4306, hsa-miR- 76.47 83.33 80.15 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 261 hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 76.47 83.18 79.24 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, 262 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 76.47 84.77 80.91 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 263 hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, 76.47 83.55 80.91 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 264 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 76.47 79.71 81.82 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 265 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 76.45 79.86 79.85 21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 266 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 76.45 84.64 80.91 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 267 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 76.45 78.29 80.83 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 268 hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, 76.42 84.16 81.97 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 269 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 76.03 79.86 78.26 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, 270 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 76 80.16 79.09 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 271 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a- 76 83.5 79.17 5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR- 15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b- 3p, 272 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 75.97 84.22 78.33 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 273 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 75.97 84.25 81.74 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-181c-3p, hsa- miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, age, hsa-miR-323b-3p, 274 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 75.97 84.16 80.08 1260b, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 275 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 75.97 83.38 80.08 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 276 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 75.97 83.61 81.74 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, age, 277 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 75.97 79.33 82.58 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-323a-3p, age, 278 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 75.95 82.4 80.76 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 279 hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 75.95 81 83.33 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa- miR-550a-3-5p, age, 280 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 75.92 83.11 81.97 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 281 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 75.92 80.55 81.82 1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 282 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 75.89 81.9 80.91 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 283 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 75.47 84.86 80 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 284 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 75.47 79.79 77.27 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b- 3p, 285 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 75.47 80.85 81.82 1260b, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a- 5p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-323a-3p, age, hsa- miR-323b-3p, 286 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 75.47 79.28 78.18 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, 287 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301- 75.45 86.11 79.24 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 288 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 75.45 81.38 81.89 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 289 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 75.45 82.33 80 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 290 hsa-miR-30b-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21- 75.45 82.6 80 5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa- miR-181c-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-550a-3-5p, hsa- miR-323b-3p, 291 hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p, 75.42 84.63 79.17 hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a- 3-5p, age, 292 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 75.42 83.22 79.17 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 293 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 75.42 80.4 79.24 1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-550a- 3-5p, hsa-miR-323b-3p, 294 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 75.42 81.62 79.77 21-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 295 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, 75.42 82.24 78.33 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR- 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR- 28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p, 296 hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR- 75.39 83.93 77.27 195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, age, hsa-miR-323b-3p, 297 hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-195-5p, hsa-miR- 75.39 82.98 81.06 377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 298 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 75.39 82.11 81.21 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803- 3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 299 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 74.97 81.08 81.74 3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 300 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195- 74.97 80.05 80.98 5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa- miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 301 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.97 81.39 80.15 1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 302 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.97 81.58 79.17 1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 303 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, 74.95 81.24 81.21 hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-28-3p, hsa-miR- 15b-3p, hsa-miR-328-3p, age, hsa-miR-323b-3p, 304 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.95 84.63 81.06 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa- miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 305 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301- 74.92 84.45 77.58 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR- 550a-3-5p, age, 306 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 74.92 83.27 80.08 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 307 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 74.92 83.38 80.08 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 308 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 74.92 84.13 81.59 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, 309 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.92 79.02 78.18 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-3- 5p, hsa-miR-323b-3p, 310 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 74.92 84.55 80.15 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-550a-3-5p, age, 311 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 74.89 82.61 80 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, age, 312 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.89 81.47 79.02 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-3- 5p, age, hsa-miR-323b-3p, 313 hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, 74.89 82.58 79.92 hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, 314 hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 74.87 80.22 78.11 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR- 323b-3p, 315 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 74.87 81.69 78.11 1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 316 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.45 79.57 80 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR- 181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 317 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.42 80.83 79.09 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa- miR-328-3p, hsa-miR-323b-3p, 318 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 74.42 79.78 79.92 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa- miR-550a-3-5p, 319 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.42 82.89 77.27 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, 320 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.42 81.51 79.47 4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, 321 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.42 82.19 78.33 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 322 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.42 79.07 80 1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-323a-3p, hsa-miR-550a-3-5p, 323 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 74.42 82.46 80.68 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 324 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 74.42 82.34 79.17 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, 325 hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 74.39 81.12 79.09 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, age, 326 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 74.39 81.78 81.67 3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa- miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-15b- 3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 327 hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 74.37 83.35 79.92 1260b, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa- miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR- 323b-3p, 328 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a- 73.89 80.88 78.18 5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa- miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b- 3p, 329 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-92b- 73.87 81.85 80.08 3p, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-323b-3p, 330 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 73.87 80.9 80.08 1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p, 331 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR- 73.87 80.45 80.15 195-5p, hsa-miR-483-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa- miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa- miR-323b-3p, 332 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 73.84 84.07 77.5 1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa- miR-550a-3-5p, age, 333 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 73.84 82.21 77.42 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR- 328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p, 334 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 73.82 80.7 79.24 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa- miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 335 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 73.42 78.81 78.26 195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, 336 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 73.39 83.36 76.52 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa- miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 337 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 73.37 78.46 76.29 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa- miR-550a-3-5p, hsa-miR-323b-3p, 338 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 73.37 78.99 78.26 1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b- 3p, 339 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 73.37 81.54 76.36 21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 340 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 73.34 80.92 78.11 130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323b-3p, 341 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 73.34 79.57 76.52 195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 342 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR- 73.32 80.36 78.11 1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa- miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, age, 343 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-21- 73.32 81.65 78.41 5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa- miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 344 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 73.32 81.51 77.95 1260b, hsa-miR-1301-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 345 hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 73.29 81.76 80.91 1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR- 328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 346 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 72.87 77.4 79.02 6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, hsa-miR-323b-3p, 347 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 72.87 80.77 79.09 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa- miR-423-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328- 3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 348 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 72.84 80.24 78.11 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, 349 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 72.84 81.71 77.35 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, 350 hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR- 72.82 82.27 78.33 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101- 3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR- 323a-3p, hsa-miR-550a-3-5p, age, 351 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 72.82 83.55 75.91 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-28- 3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, 352 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR- 72.82 81.54 78.18 1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa- miR-423-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a- 3-5p, age, hsa-miR-323b-3p, 353 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 72.79 82.57 77.35 1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR- 29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, 354 hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 72.76 81.94 76.44 4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR- 101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa- miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, 355 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 72.32 81.14 79.02 3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR- 6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, age, hsa-miR-323b-3p, 356 hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 72.29 79.72 78.11 130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-423-5p, hsa-miR- 29a-3p, hsa-miR-15b-3p, hsa-miR-550a-3-5p, hsa-miR-323b- 3p, 357 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 72.26 80.78 77.2 1301-3p, hsa-miR-21-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR- 7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, 358 hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR- 72.26 80.69 77.2 4306, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR- 374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, age, hsa-miR-323b-3p, 359 hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 71.82 76.62 77.27 1260b, hsa-miR-4306, hsa-miR-21-5p, hsa-miR-377-3p, hsa- miR-6803-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7- 5p, hsa-miR-328-3p, hsa-miR-323a-3p, 360 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR- 71.79 80.96 77.35 4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa- miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101- 3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, age, 361 hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR- 71.76 79.54 78.11 377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-15b-3p, age, 362 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR- 71.76 81.31 79.17 21-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa- miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, 363 hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR- 71.18 77.92 74.77 4306, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-374a-5p, hsa- miR-550a-3-5p, age, 364 hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-483- 70.76 76.96 78.33 5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa- miR-29a-3p, hsa-miR-7-5p, hsa-miR-323a-3p, age, 365 hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-195-5p, hsa-miR- 70.71 76.37 80.91 377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-323a-3p, hsa-miR-323b-3p, 366 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR- 70.21 77.87 76.36 483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, hsa-miR-323b-3p, 367 hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR- 70.16 80.7 74.77 1301-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR- 550a-3-5p, age, hsa-miR-323b-3p, 368 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301- 66.55 76.16 76.36 3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa- miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a- 3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-323b-3p, 369 combination 1 + rs11862974 67.11 64.36 87.8 370 combination 1 + rs7193058 74.89 79.03 86.97 371 combination 2 + rs12917707 69.63 70.47 70.15 372 combination 2 + rs11647727 68.58 71.76 83.56 373 combination 3 + rs7204342 69.13 73.18 83.48 374 combination 3 + rs7193058 69.11 72.14 83.23 375 combination 4 + rs12917707 73.84 77.37 80.3 376 combination 4 + rs11647727 72.79 77.42 83.4 377 combination 8 + rs76563024 74.92 81.29 83.56 378 combination 8 + rs7193058 74.89 79.03 80.7 379 combination 29 + rs76563024 80.18 87.08 87.08 380 combination 149 + rs76563024 78.57 85.51 84.51 381 combination 150 + rs76563024 77.3 85.51 86.71 382 combination 151 + rs76563024 75.3 85.01 84.17 383 combination 152 + rs76563024 75.3 84.7 84.20 384 combination 153 + rs76563024 74.4 83.51 85.17 385 combination 154 + rs76563024 74.3 82.5 86.18 386 combination 155 + rs76563024 74 82 84.20

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for diagnosis outcome: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, and hsa-miR-337-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for diagnosis (Table 16).

TABLE 16 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for diagnosis. N Combinations Accuracy ROC AUC Recall 387 hsa-miR-99a-3p 78.26 65.53 100.0 388 hsa-miR-99a-3p, hsa-miR-1180-3p 79.13 71.54 100.0 389 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p 78.26 75.95 100.0 390 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 79.13 77.85 100.0 4286 391 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 79.13 82.04 100.0 4286, hsa-miR-103a-2-5p 392 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 80 82.18 95.56 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p 393 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 80.87 82.62 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p 394 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 82.1 84.26 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p 395 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 84.5 81.67 92.22 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p 396 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 83.8 80.16 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p 397 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 84.5 89.17 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p 398 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 84.5 90.42 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p 399 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 83.8 91.45 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l 400 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 86.09 90.52 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p 401 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 87.83 90.38 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p 402 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 87.83 91.71 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p 403 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 86.09 90.82 94.44 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p 404 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 86.96 92.99 95.56 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p 405 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 89.7 95.25 92.22 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p 406 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 88.7 92.32 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p 407 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 90.3 95.96 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p 408 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 89.7 95.25 93.33 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a 409 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 90.3 95.29 90.0 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p 410 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 89.7 95.29 90.0 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p 411 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 90.3 93.33 90.0 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR- 30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa- miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR- 433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR- 4732-5p 412 hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR- 90.3 92.85 91.11 4286, hsa-miR-103a-2-5p, 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hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR- 1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR- 382-5p 616 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b- 86.21 94.5 91.33 5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa- miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa- miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 617 hsa-miR-20b-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR- 86.21 86.96 90.22 331-5p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR- 590-5p 618 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 86.21 90.06 92.44 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337- 5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 619 hsa-miR-30e-3p, hsa-miR-548l, 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hsa-miR- 103a-2-5p, hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p 651 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b- 85.23 93.89 90.22 5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa- miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa- miR-500a-5p, hsa-miR-382-5p 652 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 85.15 89.06 89.11 193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR- 103a-2-5p, hsa-miR-590-5p 653 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.5 87.81 90.33 193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 654 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.5 90.17 93.56 450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR- 1290, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa- miR-500a-5p 655 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.5 93.19 88.22 193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR- 103a-2-5p, hsa-miR-590-5p, hsa-miR-382-5p 656 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.7 91.02 89.22 193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132- 3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-590-3p, hsa-miR- 500a-5p 657 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.7 91.96 91.33 450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR- 1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p 658 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.7 87.39 92.44 193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132- 3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa- miR-500a-5p 659 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 86.83 90.22 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa- miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 660 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 93.81 89.11 193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485- 3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR- 4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p 661 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 85.85 90.11 193b-3p, hsa-miR-410-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-590-5p 662 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b- 84.9 89.11 89.11 5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa- miR-485-3p, hsa-miR-335-5p, hsa-miR-500a-5p, hsa-miR-590- 5p, hsa-miR-382-5p 663 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 86.83 90.22 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 664 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 92.04 92.33 450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR- 132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p 665 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 89 90.22 450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa- miR-491-5p, hsa-miR-132-3p, hsa-miR-103a-2-5p, hsa-miR- 215-5p, hsa-miR-590-3p, hsa-miR-500a-5p 666 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.9 90.56 91.33 193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR- 337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a- 5p, hsa-miR-382-5p 667 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.2 88.63 89.11 193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-132- 3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa- miR-500a-5p, hsa-miR-382-5p 668 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-491-5p, hsa-miR- 84.2 88 92.33 4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-382-5p 669 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.24 86.72 94.44 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa- miR-215-5p, hsa-miR-382-5p 670 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 84.24 89.5 89 193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR- 590-5p 671 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR- 84.17 91.96 89.11 433-3p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR- 4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p 672 hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR- 83.4 85.96 92.44 450a-5p, hsa-miR-221-5p, hsa-miR-451a, hsa-miR-491-5p, hsa- miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa- miR-500a-5p 673 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.4 87.39 90.22 193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 674 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.4 86.09 90.33 193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132- 3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa- miR-500a-5p 675 hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR- 83.6 85.41 89.11 410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-4732-5p, hsa-miR-1290, hsa-miR- 132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p 676 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR- 83.8 87.33 90 450a-5p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa- miR-4732-5p, hsa-miR-485-3p, hsa-miR-103a-2-5p, hsa-miR- 215-5p, hsa-miR-590-5p, hsa-miR-382-5p 677 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.8 89.43 89 193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-590-5p, hsa- miR-382-5p 678 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.8 90.06 89 193b-3p, hsa-miR-410-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p 679 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.8 85.41 92.44 193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa- miR-500a-5p, hsa-miR-590-5p 680 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.1 86.41 93.44 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 681 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 83.1 87.7 87.89 193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p 682 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 82.88 90.28 88.22 193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR- 485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa- miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR- 500a-5p 683 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 82.8 86.09 91.22 193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132- 3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa- miR-382-5p 684 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410- 82.73 83.69 92.44 3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR- 1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-382-5p 685 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410- 82.5 85.35 91.33 3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR- 485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa- miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR- 382-5p 686 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 82.5 87.02 89.11 193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-382-5p 687 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b- 82.5 89.11 91.44 5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa- miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-500a-5p, hsa-miR-382-5p 688 hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 82.8 88.44 90.11 193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-590- 5p, hsa-miR-382-5p 689 hsa-miR-30e-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR- 82.00 89.59 85.67 451a, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-335-5p, hsa- miR-1290, hsa-miR-337-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p 690 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 81.89 84.48 89.11 193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR- 103a-2-5p 691 hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR- 81.89 83.93 91.33 491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-590-3p, hsa-miR- 500a-5p, hsa-miR-590-5p, hsa-miR-382-5p 692 hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa- 81.89 84.3 94.67 miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR- 103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p 693 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR- 81.82 83.74 89.11 193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337- 5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p 694 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410- 81.82 85.85 91.22 3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-485-3p, hsa-miR- 1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p 695 hsa-miR-545-5p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR- 80.98 83.74 93.44 181c-3p, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-590-3p, hsa-miR-500a-5p 696 hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-501-5p, hsa-miR- 80.91 85.54 94.56 132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p 697 combination 387 + rs13335818 79.13 45.13 98.89 698 combination 388 + rs76563024 80 75.1 98.89 699 combination 389 + rs76563024 80.87 78.71 100.0 700 combination 390 + rs76563024 80.87 80.31 98.89 701 combination 392 + rs76563024 81.74 79.08 97.78 702 combination 393 + rs12934455 85.22 84.73 96.67 703 combination 395 + rs12934455 85.22 79.65 95.56 704 combination 397 + rs71384446 86.09 87.88 97.78 705 combiantion 399 + rs7203642 86.96 87.09 95.56 706 combination 400 + rs28688991 86.96 85.75 94.44 707 combination 652 + rs7203642 85.22 92.38 94.44 708 combination 653 + rs7203642 85.22 92.38 92.38 709 combination 654 + rs7203642 85.22 92.38 92.38

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for tumour stage: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, and hsa-miR-15a-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour stage (Table 17).

TABLE 17 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for tumour stage. N Combinations Accuracy ROCAUC Recall 710 hsa-miR-769-5p 72.57 66.51 0.0 711 hsa-miR-769-5p, hsa-miR-27b-3p 74.74 80.82 23.00 712 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p 78.19 83.28 50.67 713 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 78.13 86.31 58.00 629-5p 714 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 79.24 87.54 62.67 629-5p, hsa-miR-100-5p 715 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 80.23 87.59 66.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p 716 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 85.85 89.38 70.0 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p 717 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.9 90.46 69.33 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p 718 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 88.01 91.23 72.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 719 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 89.12 93.03 72.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p 720 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 88.01 93.23 76.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-5p 721 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 89.12 92.92 69.33 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p 722 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 90.06 95.64 81.33 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p 723 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 85.85 95.18 73.33 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p 724 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 89.12 94.87 65.33 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p 725 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.96 94.05 68.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p 726 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 85.85 92.26 68.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p 727 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 84.8 93.95 80.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p 728 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 85.73 94.05 72.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136 729 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.84 94.67 72.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p 730 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.9 94.1 72.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p 731 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 88.01 95.59 68.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p 732 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.9 94.92 68.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p 733 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.9 94.92 76.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p 734 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 86.9 94.72 76.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p 735 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 88.01 92.62 76.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306 736 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 90.12 94.97 76.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p 737 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 87.95 95.18 80.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p 738 hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR- 90.12 95.38 80.67 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22- 5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa- miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b- 5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR- 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 1296-5p 739 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 95.67 98.33 91.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 740 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 92.56 97.86 86.67 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p 741 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-10b-5p, hsa-miR- 92.56 97.38 90.00 12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa- miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183- 3p, hsa-miR-224-5p, hsa-miR-652-3p 742 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 92.44 98.81 88.33 195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR- 181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR- 652-3p 743 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 92.44 96.03 81.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 744 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 92.33 95.32 85.00 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 745 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.44 96.98 86.67 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p 746 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.44 97.86 86.67 12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa- miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629- 5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa- miR-652-3p 747 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.44 97.62 80.00 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652- 3p 748 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.44 96.19 86.67 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p 749 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 95.32 81.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 750 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 95.32 81.67 485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 751 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR- 91.33 96.75 81.67 10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR- 100-5p, hsa-miR-224-5p, hsa-miR-652-3p 752 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 96.9 85.00 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652- 3p 753 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 97.14 83.33 485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa- miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134- 5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa- miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 754 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 95.71 83.33 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-140-3p 755 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 94.21 81.67 485-3p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 756 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 96.03 81.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 757 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.33 96.27 78.33 195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 758 hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR- 91.33 93.41 78.33 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-15a-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p 759 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 91.22 94.21 81.67 485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa- miR-652-3p 760 hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a- 90.44 94.52 85.00 3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p 761 hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a- 90.44 96.35 85.00 3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-15a-5p, hsa- miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224- 5p, hsa-miR-652-3p 762 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hsa-miR-27a- 3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa- miR-224-5p, hsa-miR-652-3p 812 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR- 89.11 95.00 81.67 12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR- 100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 813 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 89.11 93.97 81.67 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140- 3p 814 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR- 89.11 92.46 78.33 195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa- miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR- 224-5p, hsa-miR-652-3p 815 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 89.11 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hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i- 3p 819 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR- 89.11 92.46 68.33 744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-let-7d-3p, hsa- miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-224-5p, hsa-miR- 652-3p, hsa-miR-140-3p 820 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR- 89.11 94.52 81.67 339-3p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188- 5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 821 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR- 89.11 93.65 73.33 744-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134- 5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa- miR-183-3p, hsa-miR-652-3p, hsa-miR-140-3p 822 hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR- 89.11 94.05 76.67 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa- miR-337-5p, hsa-miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629- 5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let- 7i-3p, hsa-miR-652-3p, hsa-miR-140-3p 823 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 89.11 95.95 78.33 195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188- 5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa- miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 824 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR- 89.00 96.59 80.00 195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa- miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c- 5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa- miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p 825 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 89.00 93.57 70.00 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-134-5p, hsa-miR- 1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-140-3p 826 hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR- 89.00 92.06 76.67 10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa- miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100- 5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR- 652-3p, hsa-miR-140-3p 827 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.22 93.33 73.33 195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134- 5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa- miR-224-5p, hsa-miR-652-3p 828 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR- 88.22 93.02 70.00 12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p 829 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.22 95.08 81.67 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p 830 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 88.11 95.24 85.00 10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR- 100-5p, hsa-miR-224-5p, hsa-miR-652-3p 831 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 93.57 73.33 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa- miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134- 5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa- miR-224-5p, hsa-miR-652-3p 832 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 92.94 81.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 833 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 95.24 81.67 195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a- 3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa- miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 834 hsa-miR-22-5p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR- 88.11 89.84 73.33 34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-181c-5p, hsa- miR-27a-3p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-224- 5p, hsa-let-7i-3p, hsa-miR-140-3p 835 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 95.56 81.67 744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p 836 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 97.06 80.00 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-652-3p 837 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR- 88.11 93.49 76.67 12136, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa- miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224- 5p, hsa-miR-652-3p 838 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR- 88.11 95.79 81.67 339-3p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-27a- 3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa- miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p, hsa-miR-140- 3p 839 hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 88.11 93.81 86.67 485-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p, hsa- miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224- 5p, hsa-miR-652-3p, hsa-miR-140-3p 840 hsa-miR-22-5p, hsa-miR-548a-3p, 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hsa-miR-1307-5p, hsa-miR- 84.67 92.94 71.67 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629- 5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa- miR-140-3p 977 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-10b-5p, hsa-miR- 84.67 92.46 68.33 12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa- miR-4306, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p, hsa-miR-140-3p 978 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 84.67 95.4 78.33 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 979 hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR- 83.78 89.76 68.33 10b-5p, hsa-let-7d-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa- miR-1296-5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140- 3p 980 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR- 83.78 90.16 71.67 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR- 183-3p, hsa-miR-224-5p, hsa-miR-652-3p 981 hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR- 83.78 88.97 76.67 34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa- miR-188-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR- 652-3p 982 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-485-3p, hsa-miR- 83.67 87.14 73.33 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p 983 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 83.67 90.63 78.33 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa- miR-652-3p 984 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 83.67 90.16 70.00 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 985 hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 83.56 88.49 73.33 485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa- miR-181c-5p, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-miR-15a- 5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR- 140-3p 986 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-let- 83.56 88.89 70.00 7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa- miR-181c-5p, hsa-miR-27a-3p, hsa-miR-629-5p, hsa-miR-183- 3p, hsa-let-7i-3p 987 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 83.56 90.87 70.00 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 988 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 83.56 91.43 75.00 10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa- miR-652-3p 989 hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR- 83.44 86.83 68.33 10b-5p, hsa-miR-34a-3p, hsa-miR-188-5p, hsa-miR-4306, hsa- miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-224- 5p, hsa-let-7i-3p, hsa-miR-140-3p 990 hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 82.67 86.03 61.67 12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-let-7i-3p, hsa-miR-652- 3p, hsa-miR-140-3p 991 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-195-5p, hsa-miR- 82.56 91.35 65.00 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629- 5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p 992 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR- 82.56 87.86 66.67 195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa- miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296- 5p, hsa-miR-652-3p, hsa-miR-140-3p 993 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR- 82.56 92.14 68.33 744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR- 4306, hsa-miR-27a-3p, hsa-miR-629-5p, hsa-miR-224-5p, hsa- let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p 994 hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-12136, hsa-miR- 82.56 90.48 75.00 455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652- 3p 995 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 82.56 90.4 71.67 10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR- 629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 996 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 82.56 89.05 65.00 10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR- 224-5p, hsa-miR-652-3p 997 hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR- 82.44 92.14 65.00 485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR- 15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-140-3p 998 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 82.44 90.4 70.00 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR- 134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa- miR-652-3p 999 hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR- 81.33 91.43 71.67 10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR- 27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p 1000 hsa-miR-1307-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR- 80.56 86.43 70.00 27a-3p, hsa-miR-1296-5p, hsa-miR-629-5p, hsa-miR-100-5p 1001 hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR- 76.00 80.95 51.67 744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-let-7i- 3p 1002 combination 710 + rs28544423 80.23 79.59 70.53 1003 combination 712 + rs28544423 80.35 83.95 73.96 1004 combination 713 + rs28544423 80.29 85.44 82.76 1005 combination 714 + rs28544423 81.46 86.51 83.77 1006 combination 715 + rs28544423 84.68 87.85 88.02 1007 combination 718 + rs71384446 89.12 91.13 91.93 1008 combination 719 + rs28544423 91.29 94.21 89.92 1009 combination 724 + rs11647727 89.12 92.92 92.43 1010 combination 725 + rs11647727 89.18 94.91 92.12 1011 combination 726 + rs28544423 90.18 93.13 92.71 1012 combination 727 + rs7193058 86.96 93.13 92.46 1013 combination 728 + rs13333226 86.96 92.92 93.04 1014 combination 729 + rs4297685 88.01 94.72 92.43 1015 combination 730 + rs11647727 88.01 94.41 92.37 1016 combination 737 + rs11862974 88.01 94.26 92.98 1017 combination 738 + rs28544423 91.35 96.21 92.06 1018 combination 711 + rs4293393 72.63 73.03 91.44 1019 combination 712 + rs4293393 80.35 83.95 95.14 1020 combination 713 + rs4293393 80.35 85.59 93.88 1021 combination 714 + rs4293393 82.46 86.72 94.49 1022 combination 715 + rs4293393 84.68 87.85 93.57 1023 combination 718 + rs4293393 88.07 94.1 94.1 1024 combination 719 + rs4293393 87.95 94.21 94.21 1025 combination 725 + rs4293393 90.18 93.13 92.52 1026 combination 726 + rs4293393 89.06 93.13 92.71 1027 combination 727 + rs4293393 89.06 93.13 92.46 1028 combination 728 + rs4293393 86.96 93.74 93.24 1029 combination 729 + rs4293393 89.12 94.36 92.63 1030 combination 737 + rs4293393 89.18 96.56 92.72

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for tumour grade: hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour grade. (Table 18).

TABLE 18 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for tumour grade. N Combinations Accuracy ROC AUC Recall 1031 hsa-miR-33a-5p 73.57 60.35 60.00 1032 hsa-miR-33a-5p, hsa-miR-125a-5p 73.57 77.19 75.10 1033 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p 73.51 73.95 70.0 1034 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 82.4 88.59 80.52 hsa-miR-744-5p 1035 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 81.29 85.55 79.5 hsa-miR-744-5p, hsa-miR-125b-5p 1036 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 81.35 88.35 82.3 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1037 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 82.4 92.5 85.5 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p 1038 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 82.4 91.92 84.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p 1039 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 84.62 90.74 88.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p 1040 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 85.67 88.27 86.5 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1041 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 94.14 87.31 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p 1042 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 91.09 86.5 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p 1043 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.89 94.39 88.9 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p 1044 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.89 97.72 90.0 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p 1045 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 97.38 88.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p 1046 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 96.82 96.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p 1047 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 90.06 96.76 92.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p 1048 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 96.48 92.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p 1049 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 96.43 92.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p 1050 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 95.2 88.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p 1051 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 95.47 92.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p 1052 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 87.84 95.78 92.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p 1053 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 87.84 95.47 85.33 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p 1054 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 96.34 85.33 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p 1055 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 87.84 94.83 85.33 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p 1056 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 95.38 92.0 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p 1057 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 88.95 95.69 92.0 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p 1058 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 86.73 95.41 88.0 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p 1059 hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, 87.89 95.82 96.67 hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p 1060 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 97.89 100.00 100.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1061 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 97.89 100.00 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1062 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 97.78 100.00 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1063 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 96.67 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1064 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.78 100.00 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1065 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 98.25 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1066 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 97.78 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1067 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 98.33 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1068 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 100.00 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1069 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 100.00 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1070 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 97.78 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1071 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 98.33 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1072 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.67 100.00 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1073 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 95.56 95.95 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1074 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.78 100.00 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1075 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 94.56 98.33 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1076 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 97.78 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1077 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1078 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 97.62 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1079 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 94.56 98.89 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1080 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 98.89 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1081 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 99.44 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1082 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1083 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 98.33 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1084 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.56 98.33 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1085 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.44 96.67 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1086 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 94.44 98.89 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1087 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 94.44 96.11 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1088 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 94.44 95.56 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1089 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.67 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1090 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.56 98.33 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1091 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.56 98.89 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1092 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.56 98.89 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1093 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 93.56 98.33 86.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1094 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 93.56 99.44 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1095 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.56 97.3 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1096 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 93.44 97.22 88.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1097 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.44 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1098 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.44 98.33 85.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1099 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 93.44 98.33 88.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1100 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 93.44 98.33 88.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1101 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 93.44 99.44 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1102 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 93.44 97.06 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1103 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 93.44 98.89 86.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1104 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 93.44 97.22 80.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1105 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 93.33 96.11 86.67 hsa-miR-652-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1106 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 97.78 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1107 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 97.62 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1108 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.44 98.33 81.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1109 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1110 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1111 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 100.00 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1112 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 98.33 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1113 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 97.78 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1114 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.44 98.33 88.33 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1115 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 98.89 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1116 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 97.78 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1117 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.44 99.44 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1118 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.44 98.33 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1119 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 97.22 90.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1120 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 97.06 93.33 hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1121 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 98.33 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1122 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 97.3 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1123 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 96.51 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1124 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 95.63 90.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1125 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 98.33 93.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-31-5p 1126 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 98.89 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1127 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 97.78 93.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1128 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 96.11 90.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1129 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 96.67 90.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-31-5p 1130 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 96.67 88.33 hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1131 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 96.67 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1132 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 96.35 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1133 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 96.67 85.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1134 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 96.51 80.00 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1135 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 92.33 97.78 85.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1136 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 96.75 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1137 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.33 98.17 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1138 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 97.22 85.00 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1139 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 97.22 85.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1140 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 92.33 97.22 83.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1141 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.33 97.22 85.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1142 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 92.22 95.95 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1143 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 92.22 98.33 83.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1144 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.44 98.89 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1145 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1146 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 98.33 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1147 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 98.89 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1148 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 97.78 90.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1149 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 97.22 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1150 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 99.44 96.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1151 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 97.22 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1152 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 97.78 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1153 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 96.11 88.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1154 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 97.22 88.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1155 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 98.89 86.67 hsa-miR-103a-2-5p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1156 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 98.89 85.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1157 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 96.35 85.00 hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1158 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 96.59 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1159 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 97.22 85.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1160 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 98.89 85.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1161 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 95.00 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1162 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 96.11 88.33 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1163 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.33 97.22 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1164 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.33 98.89 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1165 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 98.33 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1166 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 98.17 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1167 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.22 95.24 93.33 hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-31-5p 1168 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 91.22 97.06 81.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1169 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 91.22 97.22 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1170 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 91.22 98.33 85.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1171 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 91.22 95.4 73.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1172 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 97.22 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1173 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 91.22 96.75 90.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1174 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 97.06 91.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1175 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 97.78 88.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1176 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.22 95.95 86.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1177 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 91.22 96.51 76.67 hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1178 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.11 97.22 86.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1179 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.11 95.08 83.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1180 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.11 94.68 78.33 hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1181 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 91.11 96.11 93.33 hsa-miR-652-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1182 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 91.11 95.24 76.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1183 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 91.11 95.79 76.67 hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1184 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.44 100.00 90.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1185 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.33 98.89 93.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1186 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.22 96.75 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1187 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.22 96.75 80.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1188 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p, 90.22 96.11 83.33 hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1189 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 90.22 98.89 85.00 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1190 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.22 97.22 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1191 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.22 96.75 83.33 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1192 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.22 97.22 83.33 hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1193 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p, 90.22 95.00 90.00 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1194 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.22 97.78 85.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1195 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.22 96.03 93.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1196 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.22 94.84 86.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1197 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.22 97.06 81.67 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1198 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.22 99.44 85.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1199 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.11 97.78 73.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1200 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.11 96.19 86.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1201 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.11 93.89 86.67 hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1202 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 90.11 88.89 85.00 hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p 1203 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.11 95.56 86.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1204 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.11 95.00 83.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1205 hsa-miR-545-5p, hsa-miR-222-3p, hsa-miR-151a-5p, 90.11 92.3 71.67 hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p 1206 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 90.11 97.22 80.00 hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1207 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.11 98.89 85.00 hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1208 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.00 91.43 75.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p 1209 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.00 95.08 80.00 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-144-3p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1210 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 90.00 96.51 75.00 hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1211 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 90.00 92.7 75.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p 1212 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p, 90.00 96.51 80.00 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p 1213 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p, 89.22 95.00 86.67 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1214 hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-664a-3p, 89.22 96.67 81.67 hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1215 hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-548am-5p, 89.11 96.51 86.67 hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1216 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 89.11 96.11 86.67 hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1217 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p, 89.11 92.7 75.00 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1218 hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-483-5p, 89.11 97.22 80.00 hsa-miR-548am-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1219 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.11 98.17 81.67 hsa-miR-103a-2-5p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1220 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.11 96.19 81.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p 1221 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 89.11 97.22 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p 1222 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.11 95.95 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1223 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.11 95.79 81.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1224 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p, 89.11 93.25 83.33 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1225 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 89.11 96.75 86.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1226 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 89.00 97.62 80.00 hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1227 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.00 98.17 85.00 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1228 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 89.00 96.67 70.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1229 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 89.00 95.4 76.67 hsa-miR-103a-2-5p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1230 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 89.00 97.22 90.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1231 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p, 89.00 88.17 78.33 hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-21-3p 1232 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 89.00 95.63 83.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1233 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 89.00 97.22 78.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1234 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 88.89 97.22 80.00 hsa-miR-652-3p, hsa-miR-222-3p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-31-5p 1235 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p, 88.11 94.44 86.67 hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1236 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 88.11 94.6 86.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1237 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 88.11 96.11 88.33 hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p 1238 hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-548am-5p, 88.11 96.11 81.67 hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1239 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 88.00 96.19 75.00 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1240 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 88.00 93.41 81.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1241 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-7-1-3p, 88.00 93.97 83.33 hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1242 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p, 88.00 92.14 80.00 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1243 hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-483-5p, 88.00 97.22 80.00 hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1244 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p, 88.00 95.4 71.67 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1245 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 88.00 95.56 80.00 hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p 1246 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 88.00 93.1 81.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1247 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 88.00 95.4 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1248 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 88.00 95.95 83.33 hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1249 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 87.89 97.78 83.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1250 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p, 87.89 93.02 76.67 hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-31-5p 1251 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 87.89 95.79 85.00 hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p 1252 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 87.89 97.22 73.33 hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1253 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 87.89 95.24 70.00 hsa-miR-652-3p, hsa-miR-222-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1254 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 87.78 92.3 76.67 hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-744-5p, hsa-miR-502-3p 1255 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p, 87.00 98.17 83.33 hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1256 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 94.84 80.00 hsa-miR-103a-2-5p, hsa-miR-369-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p 1257 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 86.89 95.00 71.67 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1258 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 86.89 94.13 76.67 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1259 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 94.68 88.33 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1260 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p, 86.89 94.21 78.33 hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1261 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 86.89 96.75 78.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1262 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 93.57 76.67 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1263 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 96.51 71.67 hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1264 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 86.89 95.56 80.00 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1265 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 96.9 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1266 hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p, 86.89 94.13 80.00 hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p 1267 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p, 86.89 95.56 75.00 hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p 1268 hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p, 86.89 93.65 80.00 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p 1269 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-7-1-3p, 86.89 95.08 73.33 hsa-miR-126-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1270 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 86.89 93.25 78.33 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1271 hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 86.78 95.24 71.67 hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-128-3p 1272 hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 86.67 94.13 71.67 hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p 1273 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p, 86.67 91.75 71.67 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-501-5p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-31-5p 1274 hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-369-3p, 85.89 96.67 76.67 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-629-5p 1275 hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p, 85.78 89.44 73.33 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-21-3p 1276 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 85.78 92.22 71.67 hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1277 hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p, 85.78 94.05 75.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1278 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, 85.78 89.68 76.67 hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1279 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 85.78 96.67 80.00 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-21-3p, hsa-miR-31-5p 1280 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 85.78 95.79 80.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1281 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p, 85.78 95.00 75.00 hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p 1282 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 85.78 93.1 75.00 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1283 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 85.78 95.63 81.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1284 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 85.78 93.25 75.00 hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1285 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p, 85.67 86.59 75.00 hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-128-3p 1286 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, 85.56 91.98 68.33 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-144-3p, hsa-miR-629-5p 1287 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 85.56 95.63 76.67 hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1288 hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p, 85.56 92.22 66.67 hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-21-3p, hsa-miR-31-5p 1289 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 85.56 89.6 73.33 hsa-miR-369-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-let-7d-3p, hsa-miR-21-3p, hsa-miR-31-5p 1290 hsa-miR-545-5p, hsa-miR-151a-5p, hsa-miR-126-5p, 84.78 91.51 73.33 hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-128-3p 1291 hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-339-3p, 84.78 92.7 80.00 hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1292 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p, 84.67 88.41 66.67 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p 1293 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p, 84.67 95.79 71.67 hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p 1294 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p, 84.56 91.67 80.00 hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-31-5p 1295 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 83.56 93.33 76.67 hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-126-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p 1296 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p, 83.56 90.32 68.33 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p 1297 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 83.44 90.63 81.67 hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-128-3p, hsa-miR-31-5p 1298 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p, 83.44 83.65 78.33 hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-126-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p 1299 hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p, 82.44 87.78 66.67 hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p 1300 hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, 82.33 88.1 61.67 hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-21-3p, hsa-miR-31-5p 1301 hsa-miR-545-5p, hsa-miR-369-3p, hsa-miR-483-5p, 82.33 91.35 75.00 hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-629-5p, hsa-miR-31-5p 1302 combination 1031 + rs11647727 74.68 59.34 75.65 1303 combination 1034 + rs11862974 82.46 90.46 74.46 1304 combination 1035 + rs4297685 81.35 88.02 85.85 1305 combination 10346 + rs4297685 82.46 88.88 87.82 1306 combination 1037 + rs4297685 85.73 91.06 89.18 1307 combination 1038 + rs4297685 85.73 90.75 89.06 1308 combination 1039 + rs11862974 85.79 92.77 92.51 1309 combination 1040 + rs76563024 86.78 92.5 91.06 1310 combination 1041 + rs76563024 87.95 95.69 93.0, 1311 combination 1044 + rs76563024 89.01 95.67 92.08 1312 combination 1045 + rs76563024 90.12 95.62 98.24 1313 combination 1046 + rs76563024 89.01 95.34 99.69 1314 combination 1047 + rs4297685 91.17 97.12 99.38 1315 combination 1049 + rs76563024 89.01 96.7 99.08 1316 combination 1050 + rs76563024 87.89 96.08 98.8 1317 combination 1051 + rs7204342 88.89 96 96.65 1318 combination 1052 + rs11647727 91.11 96.31 95.23 1319 combination 1054 + rsl2934455 89.01 95.74 95.53 1320 combination 1055 + rs9928757 89.01 95.19 95.5 1321 combination 1056 + rs76563024 90 96 92.51 1322 combination 1057 + rs28544423 90 95.72 91.06 1323 combination 1058 + rs34356953 90 94.8 93.0 1324 combination 1059 + rs28544423 88.95 96.05 92.08 1325 combination 1226 + rs11647727 89.00 90.32 92.51 1326 combination 1227 + rs11647727 89.00 90.63 91.06 1327 combination 1037 + rs4293393 82.46 91.67 93.0 1328 combination 1038 + rs4293393 83.51 91.64 92.08 1329 combination 1040 + rs4293393 84.68 92.26 98.24 1330 combination 1045 + rs4293393 90.18 99.08 99.69 1331 combination 1046 + rs4293393 93.45 97.69 99.38 1332 combination 1050 + rs4293393 91.23 98.18 99.08 1333 combination 1056 + rs4293393 92.28 97.34 95.23

List of the best 29 mRNAs selected by the algorithm sorted by importance for clinical metastasis: hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for clinical metastasis (Table 19).

TABLE 19 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for clinical metastasis. N Combinations Accuracy ROC AUC Recall 1334 hsa-miR-3613-3p 92.34 58.01 70.0 1335 hsa-miR-3613-3p, hsa-miR-548l 92.34 73.27 70.0 1336 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k 92.34 82.65 80.0 1337 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 92.46 94.67 80.0 3p 1338 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 93.51 92.9 70.0 3p, hsa-miR-153-3p 1339 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.56 97.02 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p 1340 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.67 98.2 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p 1341 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 94.5 97.61 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290 1342 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.61 96.47 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p 1343 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 96.47 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1344 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 96.47 100.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484 1345 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.61 97.65 100.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p 1346 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 97.84 96.47 100.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p 1347 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 98.89 97.65 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p 1348 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 100.00 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p 1349 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 100.00 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p 1350 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 100.00 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p 1351 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 100.00 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p 1352 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 98.89 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p 1353 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 97.78 99.38 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p 1354 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 97.78 99.38 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p 1355 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 97.78 99.38 80.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age 1356 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 100.00 100.00 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p 1357 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 98.75 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p 1358 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 97.57 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p 1359 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.56 95.22 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p 1360 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 95.56 97.57 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-126-3p 1361 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 96.4 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-150-5p 1362 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377- 96.67 98.75 70.0 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa- miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p 1363 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-590-3p 1364 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1365 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1366 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1367 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382- 5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-1290 1368 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382- 5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1369 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1370 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1371 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 100.00 100.00 100.00 3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p 1372 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p 1373 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1374 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1375 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1376 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa- miR-410-3p 1377 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 100.00 100.00 100.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1378 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1379 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 100.00 100.00 100.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1380 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1381 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p 1382 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 100.00 100.00 100.00 3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-410-3p 1383 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 100.00 100.00 100.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1384 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382- 5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1385 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290, hsa-miR-410-3p 1386 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 100.00 100.00 100.00 hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1387 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1- 100.00 100.00 100.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa- miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p 1388 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1389 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1390 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-590-3p 1391 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR- 410-3p 1392 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1393 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1394 hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 100.00 100.00 100.00 3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-410-3p 1395 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1396 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 100.00 100.00 100.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290, hsa-miR-410-3p 1397 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa- miR-582-5p 1398 hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR- 100.00 100.00 100.00 671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR- 1290, hsa-miR-410-3p 1399 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa- miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150- 5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1400 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 100.00 100.00 100.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290 1401 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1402 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 100.00 100.00 100.00 miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290 1403 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290 1404 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 100.00 100.00 100.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532- 5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR- 153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa- miR-410-3p 1405 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1406 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 100.00 100.00 100.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1407 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 100.00 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR- 410-3p 1408 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 100.00 100.00 100.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1409 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1410 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1411 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 100.00 100.00 100.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 590-3p, hsa-miR-582-5p, hsa-miR-1290 1412 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 100.00 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1413 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-miR- 100.00 100.00 100.00 382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290 1414 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 100.00 100.00 100.00 miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1415 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1- 100.00 100.00 100.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-410-3p 1416 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 100.00 100.00 100.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-590-3p 1417 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 100.00 100.00 100.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-1290 1418 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.95 99.41 100.00 hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR- 126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1419 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1420 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.95 100.00 90.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342- 3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1421 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 99.41 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1422 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1423 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-1290 1424 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.95 100.00 90.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1425 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.95 100.00 90.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290 1426 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.95 100.00 90.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1427 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1- 98.95 100.00 90.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p 1428 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa- miR-671-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1429 hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 98.95 99.41 90.00 598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1430 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1431 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.95 100.00 90.00 590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1432 hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d- 98.95 100.00 100.00 3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p 1433 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.95 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1434 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 100.00 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR- 197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1435 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 96.88 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g- 3p 1436 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 98.13 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1437 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 99.38 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p 1438 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1- 98.89 99.38 90.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590- 3p, hsa-miR-410-3p 1439 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 98.89 100.00 100.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1440 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.89 98.75 90.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1441 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.89 100.00 100.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1442 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 98.75 90.00 7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582- 5p, hsa-miR-1290 1443 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 100.00 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1444 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 80.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1445 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 100.00 miR-455-3p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1446 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 100.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p 1447 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 100.00 90.00 7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290 1448 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1449 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 80.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1450 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d- 98.89 99.38 90.00 3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-410-3p 1451 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.89 91.76 80.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p, hsa-let-7g-3p 1452 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 98.89 100.00 90.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1453 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR- 98.89 100.00 90.00 455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa- miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150- 5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR- 582-5p 1454 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-miR- 98.89 100.00 100.00 382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290, hsa-miR-410-3p 1455 hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR- 98.89 98.82 100.00 671-5p, age, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g- 3p 1456 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1- 98.89 99.38 90.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa- miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p 1457 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.89 100.00 90.00 590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa- miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290, hsa-miR-410-3p 1458 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290 1459 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 98.75 90.00 7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 582-5p, hsa-miR-1290 1460 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 99.38 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1461 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 100.00 6803-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1462 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 98.89 100.00 100.00 miR-671-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290 1463 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 95.29 80.00 7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1464 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290 1465 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa- 98.89 98.13 90.00 miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1466 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 100.00 miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1467 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 98.89 99.38 90.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-410-3p 1468 hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR- 98.89 100.00 90.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR- 590-3p 1469 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 98.13 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1470 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d- 98.89 97.65 80.00 3p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-410-3p 1471 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 98.89 99.38 100.00 3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1472 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.89 100.00 100.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1473 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 100.00 80.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342- 3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-miR-1290 1474 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 99.38 90.00 miR-455-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR- 153-3p, hsa-miR-582-5p, hsa-miR-1290 1475 hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 98.89 98.82 100.00 miR-382-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p 1476 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 97.65 80.00 545-5p, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p 1477 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 98.13 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1478 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 98.89 100.00 100.00 3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-410-3p 1479 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR- 150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1480 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 90.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290 1481 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 100.00 miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1482 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1- 98.89 100.00 100.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-590-3p 1483 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 97.5 90.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let- 7g-3p 1484 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 99.38 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-1290, hsa-miR-410-3p 1485 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 98.89 100.00 100.00 miR-671-5p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR- 126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1486 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1487 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.89 100.00 100.00 hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1488 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 100.00 90.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290 1489 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 98.89 100.00 90.00 miR-671-5p, age, hsa-miR-342-3p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290 1490 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 100.00 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-1290 1491 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 98.89 100.00 80.00 7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1492 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.89 100.00 100.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p 1493 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 98.89 100.00 100.00 hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1494 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 98.89 100.00 90.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290, hsa-miR-410-3p 1495 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 98.89 98.75 90.00 6803-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1496 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 98.89 98.75 90.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa- miR-410-3p 1497 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 98.89 98.75 90.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1498 hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 98.89 100.00 80.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-410-3p 1499 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 98.82 80.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g- 3p 1500 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 98.89 96.88 90.00 miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582- 5p 1501 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d- 98.89 100.00 100.00 3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1502 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 98.89 99.38 90.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1503 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa- 97.89 99.41 90.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, age, hsa-miR- 532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1504 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1- 97.89 100.00 80.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-590-3p 1505 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 97.89 100.00 80.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1506 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 97.84 100.00 80.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382- 5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1507 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.84 100.00 80.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa- miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290 1508 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.84 99.38 80.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa- miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 1290, hsa-miR-410-3p 1509 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 97.84 99.38 90.00 3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1510 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671- 97.84 98.75 90.00 5p, age, hsa-miR-342-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-590-3p, hsa-miR-582-5p 1511 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 97.84 100.00 80.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1512 hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 97.84 100.00 80.00 382-5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-410-3p 1513 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.84 100.00 80.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa- miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1514 hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR- 97.84 96.25 80.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-1290 1515 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 97.84 100.00 80.00 miR-590-5p, hsa-miR-455-3p, hsa-miR-598-3p, hsa-miR-671- 5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR- 590-3p, hsa-miR-1290 1516 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.84 96.47 80.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1517 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.84 96.47 80.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-let-7g-3p 1518 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR- 97.84 98.82 70.00 598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1519 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 97.84 100.00 100.00 miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1520 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 97.84 100.00 100.00 miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR- 197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1521 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.84 100.00 90.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-1290 1522 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 97.84 100.00 90.00 miR-455-3p, age, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1523 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.84 98.82 70.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa- miR-671-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126- 3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR- 590-3p, hsa-let-7g-3p 1524 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.84 96.47 80.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1525 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 96.95 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-1290, hsa-miR-410-3p 1526 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR- 97.78 98.75 100.00 197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1527 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 97.57 70.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g- 3p 1528 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 99.38 90.00 hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-377-3p, hsa-miR-582-5p 1529 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 98.82 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1530 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.13 70.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1531 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 97.02 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa- let-7g-3p 1532 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let- 97.78 98.13 90.00 7d-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR- 410-3p 1533 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 95.77 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1534 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 100.00 80.00 7d-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1535 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 98.82 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1536 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 96.95 70.00 7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1537 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.75 90.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1538 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 93.97 70.00 6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-590-3p 1539 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.75 90.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p 1540 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR- 97.78 100.00 80.00 598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290 1541 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.78 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p 1542 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-590- 97.78 98.75 90.00 5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR- 671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1543 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 97.78 99.38 70.00 3p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p 1544 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.78 100.00 100.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-410-3p 1545 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 96.88 70.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-342-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-590- 3p, hsa-let-7g-3p 1546 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 97.57 70.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-590-3p 1547 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 99.38 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1548 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 97.78 98.75 70.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p 1549 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 98.75 90.00 7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-miR-1290 1550 hsa-miR-484, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR- 97.78 98.82 60.00 382-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1551 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 99.38 70.00 6803-3p, hsa-miR-455-3p, age, hsa-miR-342-3p, hsa-miR-197- 3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290 1552 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 91.69 70.00 7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p 1553 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 95.29 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-671-5p, age, hsa-miR-342- 3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1554 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 84.26 70.00 6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1555 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 99.38 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1556 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 98.82 70.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342- 3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-410-3p 1557 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 95.29 80.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let- 7g-3p 1558 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 91.69 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1559 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1- 97.78 99.38 70.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1560 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 97.57 70.00 7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1561 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 97.57 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-410-3p, hsa-let-7g-3p 1562 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-590- 97.78 98.75 70.00 5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR- 671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1563 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 97.78 98.82 90.00 miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1564 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 97.78 98.75 90.00 hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-410-3p 1565 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let- 97.78 97.65 70.00 7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1566 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 99.38 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1567 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.13 70.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-let-7g-3p 1568 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa- 97.78 98.13 90.00 miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1569 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 100.00 70.00 6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1570 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 94.45 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1571 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 98.75 70.00 7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1572 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 89.96 70.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1573 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 97.78 99.38 90.00 miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, age, hsa-miR- 342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290 1574 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 98.75 70.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1575 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 90.92 70.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-532-5p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1576 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.13 90.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p 1577 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 97.78 98.75 90.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p 1578 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa- 97.78 90.37 70.00 miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-150-5p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-410-3p, hsa-let-7g-3p 1579 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 98.2 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1580 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 97.57 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1581 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR- 97.78 94.12 80.00 7-1-3p, age, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-let-7g-3p 1582 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa- 97.78 99.38 70.00 miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR- 410-3p, hsa-let-7g-3p 1583 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 97.78 98.2 70.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1584 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 98.75 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1585 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 97.78 98.75 70.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR- 410-3p 1586 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 97.78 99.38 70.00 6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1587 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 98.13 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1588 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 97.78 99.38 70.00 7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1589 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 97.78 100.00 90.00 miR-598-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR- 126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p 1590 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 97.78 93.49 70.00 590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa- miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1591 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 96.95 70.00 6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1592 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa- 97.78 92.32 70.00 miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR- 197-3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g- 3p 1593 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 97.78 92.32 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382- 5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1594 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 97.78 95.29 80.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-410-3p 1595 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.78 99.38 70.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa- miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p 1596 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.78 99.41 90.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1597 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 96.78 99.38 70.00 3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1598 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.78 100.00 70.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p 1599 hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, 96.73 97.57 100.00 hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-410-3p 1600 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 96.73 100.00 80.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-410-3p 1601 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.73 97.02 60.00 590-5p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1602 hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.73 100.00 90.00 hsa-miR-598-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-410-3p 1603 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.73 98.2 60.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290 1604 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 96.73 99.38 100.00 3p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410- 3p 1605 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 96.73 97.5 60.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p 1606 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.73 99.38 60.00 6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1607 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR- 96.73 100.00 60.00 598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1608 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.73 97.57 60.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p 1609 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 96.73 98.13 60.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-1290, hsa-miR-410-3p 1610 hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa- 96.73 96.99 70.00 miR-532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1611 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.73 97.02 60.00 590-5p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-1290, hsa-miR-410-3p 1612 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.73 95.29 60.00 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa- miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR- 1290, hsa-let-7g-3p 1613 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.73 98.79 100.00 hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-410-3p 1614 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 96.73 97.54 90.00 342-3p, hsa-miR-126-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1615 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-6803-3p, hsa-miR- 96.73 92.32 70.00 455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-let-7i-3p, hsa- miR-222-3p, hsa-miR-582-5p 1616 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 96.73 98.82 60.00 miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p 1617 hsa-miR-545-5p, hsa-miR-7-1-3p, hsa-miR-342-3p, hsa-miR- 96.73 92.87 90.00 532-5p, hsa-miR-126-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290 1618 hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.73 99.38 90.00 hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p 1619 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 96.73 95.81 70.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let- 7g-3p 1620 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d- 96.73 91.91 80.00 3p, hsa-miR-598-3p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR- 410-3p 1621 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.73 95.7 60.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1622 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.73 99.38 60.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-410-3p, hsa-let-7g-3p 1623 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.67 95.85 50.00 598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1624 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age, 96.67 92.94 70.00 hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR- 222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1625 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.67 98.13 70.00 6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa- miR-1290 1626 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-let-7d- 96.67 94.52 50.00 3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR- 153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1627 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 96.67 98.2 80.00 miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1628 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.67 97.57 50.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR- 410-3p 1629 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.67 97.57 50.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290 1630 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 96.67 88.79 70.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p, hsa-let-7g-3p 1631 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d- 96.67 97.65 70.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-532-5p, hsa- miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p 1632 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.67 97.65 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150- 5p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-let-7g-3p 1633 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.67 98.82 50.00 6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa- let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1634 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 96.67 95.7 70.00 7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 582-5p, hsa-miR-1290, hsa-miR-410-3p 1635 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-7-1-3p, hsa-miR-598- 96.67 96.47 40.00 3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1636 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 96.67 93.42 70.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-342-3p, hsa-miR-150-5p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p 1637 hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-let-7d- 96.67 92.87 50.00 3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa- miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR- 590-3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p 1638 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.67 97.65 60.00 590-5p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa-miR-197- 3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290 1639 hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, age, hsa- 96.67 98.75 70.00 miR-382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-582-5p 1640 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.67 98.75 50.00 545-5p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa- miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR- 150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let- 7g-3p 1641 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 96.67 95.63 70.00 6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR- 126-3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p 1642 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.67 98.13 70.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa- miR-671-5p, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150- 5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-let-7g-3p 1643 hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 96.67 97.57 60.00 3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa- let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1644 hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.67 99.38 80.00 hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa- miR-222-3p, hsa-miR-377-3p 1645 hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, 96.67 97.57 80.00 hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa- miR-222-3p, hsa-miR-410-3p 1646 hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR- 96.67 100.00 60.00 671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR- 410-3p 1647 hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 96.67 96.4 80.00 382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1648 hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa- 96.67 97.57 100.00 miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582- 5p, hsa-miR-410-3p 1649 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.67 95.77 70.00 590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p 1650 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR- 96.67 98.13 50.00 545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa- miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let- 7g-3p 1651 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR- 96.67 91.88 70.00 6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa- miR-153-3p, hsa-miR-582-5p, hsa-let-7g-3p 1652 hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 95.73 96.43 80.00 671-5p, age, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126- 3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR- 590-3p, hsa-miR-582-5p 1653 hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 95.67 98.24 70.00 miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p 1654 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 95.67 99.41 60.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa- miR-377-3p 1655 hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 95.67 98.75 70.00 3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582- 5p, hsa-miR-410-3p 1656 hsa-miR-30e-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 95.67 97.57 60.00 miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-410-3p 1657 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR- 95.67 98.2 50.00 590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p 1658 hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 95.67 94.6 50.00 671-5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410- 3p 1659 hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p, 95.67 95.7 50.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa- miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-410-3p, hsa-let-7g-3p 1660 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1- 95.67 98.2 80.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-410-3p 1661 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa- 95.61 98.13 50.00 miR-455-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342- 3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa- miR-377-3p, hsa-miR-153-3p, hsa-miR-410-3p 1662 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 95.61 97.57 40.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR- 410-3p 1663 hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7- 95.61 98.2 60.00 1-3p, age, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p 1664 hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR- 95.61 87.32 50.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-382-5p, hsa- miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222- 3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let- 7g-3p 1665 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 95.61 96.29 90.00 miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR- 377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1666 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa- 95.61 94.45 50.00 miR-455-3p, hsa-let-7d-3p, age, hsa-miR-342-3p, hsa-miR- 532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p 1667 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, age, hsa-miR- 95.61 95.74 80.00 382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1668 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa- 95.61 95.85 60.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa- miR-1290, hsa-miR-410-3p 1669 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-598-3p, hsa- 95.61 99.41 50.00 miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa- miR-1290 1670 hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR- 95.61 96.32 80.00 671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-1290, hsa-miR-410-3p 1671 hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 95.61 95.7 60.00 7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126- 3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR- 582-5p, hsa-miR-1290 1672 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-671- 95.61 95.29 50.00 5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-410-3p, hsa-let-7g-3p 1673 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 95.61 99.38 60.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p 1674 hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR- 95.61 95.77 60.00 671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-let-7g- 3p 1675 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 95.61 100.00 40.00 miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-410-3p, hsa- let-7g-3p 1676 hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR- 95.61 98.75 60.00 382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1677 hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7- 95.61 89.89 50.00 1-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p, hsa-let-7g-3p 1678 hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 95.61 98.13 60.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1679 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1- 95.61 96.47 40.00 3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153- 3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1680 hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, 95.61 97.57 80.00 age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa- miR-377-3p, hsa-miR-410-3p 1681 hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa- 95.56 97.57 90.00 miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1682 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671- 95.56 97.57 50.00 5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR- 590-3p, hsa-miR-582-5p 1683 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR- 95.56 97.57 90.00 342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1684 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-let-7d- 95.56 97.5 40.00 3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377- 3p, hsa-miR-590-3p, hsa-miR-410-3p 1685 hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa- 95.56 96.95 60.00 miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-582-5p, hsa-miR-410-3p 1686 hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, 95.56 93.9 40.00 age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR- 590-3p, hsa-miR-1290, hsa-miR-410-3p 1687 hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 95.56 97.57 50.00 3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa- miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p 1688 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671- 94.62 98.82 60.00 5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-miR-410-3p 1689 hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7- 94.62 98.82 60.00 1-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590- 3p, hsa-miR-582-5p 1690 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 94.56 95.22 30.00 598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532- 5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p 1691 hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 94.56 95.85 30.00 miR-382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222- 3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa- miR-410-3p 1692 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-532- 94.56 90.96 80.00 5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-582-5p, hsa-miR-410-3p 1693 hsa-miR-30e-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 94.56 94.67 80.00 3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-let-7g-3p 1694 hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598- 94.56 95.77 40.00 3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410- 3p 1695 hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, 94.5 96.95 20.00 hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR- 126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa- miR-410-3p, hsa-let-7g-3p 1696 hsa-miR-30e-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa- 94.5 96.43 50.00 miR-197-3p, hsa-miR-222-3p, hsa-miR-590-3p, hsa-miR-582- 5p, hsa-miR-410-3p, hsa-let-7g-3p 1697 hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 94.5 93.42 40.00 3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p 1698 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, age, hsa- 94.5 98.75 60.00 miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126- 3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-582-5p, hsa-miR-410-3p 1699 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, age, hsa-miR- 94.5 96.32 80.00 382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1700 hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR- 94.5 97.57 60.00 590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR- 377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p 1701 hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let- 94.5 91.99 70.00 7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582-5p 1702 hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, 94.5 97.02 40.00 age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa- miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p 1703 hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1- 94.44 96.4 50.00 3p, hsa-miR-382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa- miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1704 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR- 93.45 93.97 60.00 197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p 1705 hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR- 93.45 96.4 20.00 7-1-3p, hsa-miR-598-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-582-5p, hsa-miR-410-3p 1706 hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa- 93.33 97.57 50.00 miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i- 3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR- 410-3p 1707 hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-197-3p, hsa-miR- 92.34 92.79 0.00 222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1708 hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-222- 92.34 92.79 0.00 3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p 1709 combination 1337 + rs11647727 93.51 94.71 86.62 1710 combination 1338 + rs11647727 94.56 86.36 85.99 1711 combination 1339 + rs13329952 96.67 93.42 94.12 1712 combination 1340 + rs9928757 96.73 96.36 94.12 1713 combination 1341 + rs11647727 94.5 94.04 94.12 1714 combination 1344 + rs4297685 96.73 85.88 91.76 1715 combination 1345 + rs4297685 95.67 85.88 92.94 1716 combination 1353 + rs4293393 97.78 95.29 88.2 1717 combination 1354 + rs4293393 97.78 92.94 87.3 1718 combination 1356 + rs13335818 96.67 90.59 95.1 1719 combination 1359 + rs13335818 95.61 90.44 97.1 1720 combination 1360 + rs13335818 95.61 88.64 92.94 1721 combination 1681 + rs11647727 95.61 89.12 91.76 1722 combination 1682 + rs11647727 95.61 89.12 94.12

Example 3: Circulating Plasma miRNAs Profiling in the Prospective Multicentric Cohort

Then, the inventors repeat the same type of statistical analysis restricted to the prospective multicentric cohort only, consisting of 59 patients with a renal mass (either benign or malignant) and 51 controls.

The inventors found a set of 6 miRNAs that was significantly differentially expressed (p value <0.05) in plasma of patients with a renal mass (n=59) compared with controls (n=51). In addition, 12 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (0.05<p value <0.1)(Table 20).

TABLE 20 Differentially expressed miRNAs in patients with a renal mass (n = 59) compared with controls (n = 51). miRNA FC* p value hsa-miR-423-5p 1.21 0.006 hsa-miR-378a-3p 1.22 0.02 hsa-miR-877-5p 1.32 0.03 hsa-miR-505-3p 1.18 0.03 hsa-miR-2110 1.31 0.03 hsa-miR-500a-3p 1.15 0.047 hsa-miR-4306 1.16 0.05 hsa-miR-499a-5p 1.36 0.05 hsa-miR-483-5p 1.31 0.06 hsa-miR-376c-3p 0.76 0.06 hsa-miR-361-5p 1.17 0.07 hsa-miR-494-3p 0.69 0.08 hsa-miR-28-3p 1.21 0.08 hsa-miR-377-3p 0.84 0.08 hsa-miR-154-3p 0.86 0.08 hsa-miR-320e 1.17 0.08 hsa-miR-331-3p 0.88 0.09 hsa-miR-30b-5p 0.90 0.09 *fold changes (>1 increased; <1 decreased expression in patients with a renal mass)

Then, the inventors investigated whether patients with a benign mass were associated with a specific miRNA signature that significantly differs from patients with a malignant lesion (RCC). The inventors observed 26 miRNAs significantly differentially expressed in patients with a benign mass (n=17) compared with RCC patients (n=42),In addition, 17 miRNAs showed a trend towards statistical significance (0.05<p value <0.1)(Table 21).

TABLE 21 Differentially expressed miRNAs in patients with a benign mass (n = 17) compared with RCC patients (n = 42). miRNA FC p value* hsa-miR-337-5p 1.40 0.002 hsa-miR-550a-3-5p 1.85 0.003 hsa-miR-574-5p 1.71 0.01 hsa-miR-130b-5p 1.45 0.01 hsa-miR-132-3p 1.49 0.01 hsa-miR-103a-2-5p 1.18 0.01 hsa-miR-99a-3p 1.78 0.02 hsa-miR-1249-3p 1.35 0.02 hsa-miR-375-3p 1.43 0.02 hsa-miR-1290 1.45 0.02 hsa-miR-1180-3p 0.55 0.02 hsa-miR-29c-5p 0.81 0.03 hsa-miR-214-3p 1.38 0.03 hsa-miR-362-3p 1.27 0.03 hsa-miR-223-3p 0.82 0.03 hsa-miR-181a-5p 0.77 0.03 hsa-miR-205-5p 1.44 0.03 hsa-miR-582-5p 1.33 0.03 hsa-miR-196b-5p 1.46 0.03 hsa-miR-497-5p 1.14 0.04 hsa-miR-151a-3p 0.77 0.04 hsa-miR-361-3p 0.76 0.04 hsa-miR-450a-5p 1.43 0.04 hsa-miR-532-3p 1.28 0.04 hsa-miR-410-3p 1.49 0.047 hsa-miR-6803-3p 1.28 0.047 hsa-let-7d-5p 0.76 0.053 hsa-miR-1277-3p 1.38 0.053 hsa-miR-1260a 1.28 0.059 hsa-miR-96-5p 1.16 0.059 hsa-miR-31-5p 1.29 0.061 hsa-miR-942-5p 1.28 0.061 hsa-miR-1260b 1.21 0.074 hsa-miR-26a-5p 0.88 0.074 hsa-miR-30d-5p 0.88 0.074 hsa-miR-181c-5p 0.75 0.076 hsa-miR-7-l-3p 1.22 0.079 hsa-miR-590-3p 1.16 0.082 hsa-miR-590-5p 1.19 0.085 hsa-miR-421 1.22 0.088 hsa-miR-32-3p 1.31 0.091 hsa-miR-326 0.76 0.098 hsa-miR-3613-3p 0.79 0.098 *fold changes (>1 increased; <1 decreased expression in patients with a benign mass)

A panel of 11 miRNAs was found to be significantly differentially expressed between low grade RCC patients (n=31) and high grade cases (n=11), while 8 miRNAs showed a trend towards statistical significance (0.05<p value <0.1) (Table 22).

TABLE 22 Differentially expressed miRNAs (p value ≤ 0.05) in low grade RCC patients (n = 31) compared with high grade RCC patients (n = 11). miRNA FC* p value hsa-miR-103a-2-5p 1.23 0.03 hsa-miR-150-5p 0.61 0.03 hsa-miR-629-5p 1.38 0.03 hsa-miR-433-3p 1.89 0.04 hsa-miR-148a-3p 0.74 0.04 hsa-miR-29a-3p 0.72 0.04 hsa-miR-29b-3p 0.73 0.04 hsa-miR-29c-5p 0.76 0.04 hsa-let-7e-5p 1.17 0.0497 hsa-miR-27a-3p 0.76 0.0497 hsa-miR-342-3p 0.73 0.0497 hsa-miR-382-5p 2.17 0.060 hsa-miR-151a-3p 1.29 0.068 hsa-miR-10a-5p 0.73 0.087 hsa-miR-202-5p 0.79 0.087 hsa-miR-4306 1.32 0.087 hsa-miR-34a-5p 0.74 0.098 hsa-miR-369-3p 1.37 0.098 hsa-miR-584-5p 1.22 0.098 *fold changes (>1 increased; <1 decreased expression in high grade RCC patients)

Similarly, the inventors found that 7 miRNAs can significantly distinguish between low stage RCC patients (n=34) and high stage RCC patients (n=8), while 6 miRNAs showed a p value between 0.06 and 0.09, indicating a trend towards statistical significance (Table 23).

TABLE 23 Differentially expressed miRNAs in low stage RCC patients (n = 34) compared with high stage RCC patients (n = 8). miRNA FC p value* hsa-miR-324-3p 0.64 0.01 hsa-miR-215-5p 0.54 0.01 hsa-miR-769-5p 2.06 0.01 hsa-miR-598-3p 1.67 0.03 hsa-miR-320a-3p 1.32 0.04 hsa-miR-548a-3p 1.55 0.04 hsa-miR-190a-5p 0.70 0.04 hsa-miR-491-5p 1.34 0.06 hsa-miR-335-5p 0.83 0.07 hsa-miR-423-3p 1.32 0.09 hsa-miR-100-5p 0.60 0.09 hsa-miR-224-5p 0.61 0.09 hsa-miR-421 0.72 0.09 *fold changes (>1 increased; <1 decreased expression in high stage RCC patients)

No analysis regarding miRNAs' signatures related to metastatic outcome were performed in the prospectic multicentic phase because only one patient was affected by a metastatic process.

Similarly to the total study cohort analysis reported above, in addition to single biomarker analysis, the inventors identified unique sets of miRNAs (miRNA signatures) leading to a significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms.

Again, the inventors investigated clinical parameters in association with miRNAs biomarkers, using the feature selection algorithm, and the variable age resulted predictive in association with some miRNAs in screening, and diagnosis. It is important to underline that the single variable age, using the same evaluation metric, performed significantly less than the presented combinations with an accuracy of 52.72%, recall of 38.33%, and ROC AUC of 57.82% for screening and an accuracy of 38.78%, recall of 62.5%, and ROC AUC of 56.64% for diagnosis.

In addition, the inventors combined some of the identified miRNAs signatures (together or not with age) with SNPs, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms (Table 24, 25, 26, 27).

This is the list of the best 29 mRNA selected by the algorithm sorted by importance for screening outcome: hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, and hsa-miR-494-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening (Table 24).

TABLE 24 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for screening. N Combinations Accuracy ROC AUC Recall 1723 hsa-miR-378a-3p 60.61 64.57 86.8 1724 hsa-miR-378a-3p, hsa-miR-328-3p 59.7 62.72 80.71 1725 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p 69.74 69.33 81.66 1726 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age 68.83 75.54 85.14 1727 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 68.83 74.94 82.37 hsa-miR-361-5p 1728 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 70.69 75.89 84.15 hsa-miR-361-5p, hsa-miR-1260b 1729 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 72.55 81.78 79.84 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p 1730 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 75.24 82.96 81.5 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p 1731 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 74.37 83.15 83.28 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p 1732 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 78.92 85 83.28 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1733 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 79.87 85.67 79.84 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p 1734 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 77.14 86.35 81.58 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p 1735 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 74.24 86.59 81.66 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p 1736 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 79.83 87.87 79.80 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p 1737 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 82.64 88.87 82.45 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p 1738 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 81.65 88.35 79.76 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p 1739 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 77.92 88.43 80.67 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p 1740 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 81.65 90.81 77.94 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326 1741 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 81.65 90.31 78.02 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110 1742 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 82.6 92.35 78.02 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p 1743 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 81.69 91.35 81.54 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p 1744 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 80.82 89.56 80.67 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p 1745 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 80.65 89.8 81.54 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p 1746 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 78.92 90.35 80.63 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306 1747 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 79.74 90.67 82.37 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-423-3p 1748 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 80.69 90.67 80.59 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p 1749 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 81.65 91.17 81.5 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p 1750 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 82.6 91.48 81.5 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p 1751 hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age, 83.46 91.07 80.63 hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR- 550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR- 202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c- 5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p 1752 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 85.41 91.3 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1753 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 85.41 89.93 90 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1754 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 85.41 89.8 90 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1755 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 85.32 89.94 86.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1756 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 84.5 89.78 88.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-532-3p, hsa-miR- 15b-3p 1757 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 84.46 89.76 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p, hsa-miR-15b-3p 1758 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 84.46 90.43 88.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1759 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 84.46 90.41 86.67 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-miR-6803- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1760 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 84.46 86.39 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1761 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 84.46 90.61 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1762 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 84.42 88.52 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1763 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 84.42 86.15 86.67 hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa- miR-361-5p, hsa-miR-532-3p 1764 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 84.42 89.94 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p, hsa-miR-15b-3p 1765 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-423-5p, 84.42 91.78 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1766 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 84.37 93.67 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p, hsa-miR-7-5p 1767 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 84.37 93.31 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1768 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 83.59 86.39 86.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-1260b, hsa-miR-532- 3p, hsa-miR-15b-3p 1769 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 83.59 90.43 86.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1770 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 83.59 90.09 86.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1771 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 83.55 89.74 86.67 miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1772 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 83.55 90.91 85 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-15b-3p 1773 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 83.55 91.8 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa- miR-15b-3p, hsa-miR-7-5p 1774 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 83.55 88.33 86.67 miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1775 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 83.55 90.3 88.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1776 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 83.55 91 86.67 miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1777 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 83.55 87.87 83.33 hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-15b-3p 1778 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 83.51 89.91 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1779 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 83.51 90.74 85 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 101-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1780 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 83.51 85.46 85 hsa-miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa- miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p 1781 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 82.68 84.63 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1782 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 82.64 85.94 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p 1783 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 82.64 90.28 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1784 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 82.64 90.24 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 101-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1785 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 82.64 89.15 85 miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1786 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 82.64 88.43 83.33 hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa- miR-15b-3p 1787 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 82.64 88.07 81.67 hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1788 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 82.64 89.76 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1789 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 82.6 89.39 85 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 101-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1790 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 82.6 92.11 83.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p, hsa-miR-7-5p 1791 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 82.6 88.93 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1792 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 82.6 89.65 85 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-6803- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1793 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 82.51 92.37 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1794 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 82.51 92 80 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1795 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa- 81.73 83.63 83.33 miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR- 15b-3p 1796 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 81.73 90.63 80 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-532-3p, hsa-miR-15b-3p 1797 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 81.73 92.13 83.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1798 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 81.73 88.72 80 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-323b- 3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-532-3p 1799 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 81.73 87.48 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-6803-3p, hsa-miR-323b-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1800 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 81.73 87.28 83.33 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1801 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa- 81.73 87.04 83.33 miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1802 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 81.69 91.19 81.67 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423- 3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1803 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 81.69 86.39 83.33 197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1804 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 81.69 89.93 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p 1805 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 81.69 89.28 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1806 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 81.69 87.5 83.33 miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1807 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 81.69 89.22 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p 1808 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-197-3p, 81.69 85.89 85 hsa-miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1809 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 81.65 87.69 80 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1810 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-197-3p, 81.65 86.17 86.67 hsa-miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa- miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p, hsa-miR-15b-3p 1811 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 81.65 86.7 81.67 hsa-miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa- miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p 1812 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 81.65 92 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1813 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 81.65 90.15 83.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1814 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 81.65 88.15 83.33 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b- 3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1815 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p, 81.65 88.93 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1816 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 81.65 88.5 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532- 3p, hsa-miR-15b-3p, hsa-miR-7-5p 1817 hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-1301-3p, 81.6 86.13 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-323b-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1818 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 81.6 91.35 81.67 miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1819 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 81.6 88.22 81.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-7-5p 1820 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 80.87 83.78 80 hsa-miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1821 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 80.82 86.56 81.67 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1822 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 80.82 88.09 78.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 15b-3p 1823 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, 80.82 85.43 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p 1824 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 80.78 87.11 81.67 miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1825 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 80.78 86 83.33 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1826 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 80.78 90.46 85 miR-197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1827 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 80.78 83.74 83.33 hsa-miR-1301-3p, hsa-miR-326, hsa-miR-197-3p, hsa- miR-4306, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-miR- 361-5p, hsa-miR-1260b 1828 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 80.78 84.65 85 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-4306, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa- miR-532-3p 1829 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 80.78 88.56 85 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1830 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 80.78 83.37 83.33 hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa- miR-361-5p, hsa-miR-15b-3p 1831 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- 80.78 85.7 81.67 miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa- miR-15b-3p 1832 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 80.78 88.24 81.67 4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1833 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p, 80.78 83.46 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 4306, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1834 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 80.78 88.24 83.33 2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-323b- 3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1835 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 80.78 88.31 80 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 2110, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1836 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 80.78 87.76 78.33 miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1837 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 80.78 89.78 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1838 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 80.74 89.31 81.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, age, hsa- miR-361-5p, hsa-miR-1260b, hsa-miR-532-3p 1839 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 80.74 90.2 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b- 3p, hsa-miR-7-5p 1840 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 80.74 88.13 83.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-miR-6803- 3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-15b-3p, hsa-miR-7-5p 1841 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 80.74 88.89 81.67 hsa-miR-2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, age, hsa- miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1842 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 80.74 88.48 81.67 hsa-miR-423-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-15b-3p 1843 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 80.69 87.65 81.67 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p 1844 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p, 80.69 91.22 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1845 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p, 80.69 89.85 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1846 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p, 79.96 85.61 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1847 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa- 79.91 86.43 81.67 miR-326, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1848 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 79.91 88.56 81.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p 1849 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 84.81 85 hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1850 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 79.91 81.26 85 197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1851 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 87.04 80 hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 15b-3p 1852 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 83.74 86.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1853 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 79.91 85.61 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1854 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 86.44 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-532- 3p, hsa-miR-15b-3p 1855 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 88.44 81.67 hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1856 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 86.59 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1857 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.91 86.7 80 hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR- 6803-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1858 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa- 79.91 86.06 80 miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1859 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-1301-3p, 79.87 85.91 86.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR- 361-5p, hsa-miR-579-3p, hsa-miR-15b-3p 1860 hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa- 79.87 86.94 83.33 miR-1301-3p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1861 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p, 79.87 83.65 85 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-4306, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1862 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 79.87 86.3 78.33 miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1863 hsa-miR-202-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 79.87 85.65 80 miR-326, hsa-miR-2110, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-15b-3p 1864 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 79.87 84.72 81.67 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p 1865 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 79.87 89.59 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b- 3p, hsa-miR-7-5p 1866 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79.87 85.56 81.67 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa- miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p 1867 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 79.83 89.17 81.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- miR-197-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-6803-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1868 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 79.83 89.61 81.67 miR-197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1869 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p, 79.83 83.8 85 hsa-miR-1301-3p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-361-5p, hsa-miR-532-3p 1870 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 79.83 87.94 80 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-6803-3p, hsa-miR-323b-3p, age, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1871 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 79.83 89.2 81.67 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 2110, hsa-miR-197-3p, hsa-miR-6803-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-15b-3p 1872 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 79.83 88.35 81.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-2110, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-15b-3p 1873 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p, 79.83 87.09 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1874 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 79.78 85.17 81.67 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa- miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p 1875 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 79.78 87.61 78.33 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR- 494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1876 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 79 85.63 80 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1877 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 79 85.61 81.67 miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa- miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa- miR-15b-3p 1878 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 79 85.91 83.33 miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1879 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-197-3p, 79 83.2 81.67 hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa- miR-494-3p, hsa-miR-361-5p, hsa-miR-532-3p 1880 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 79 81.44 83.33 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1881 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR- 79 86.81 80 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1882 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 79 83.59 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-579-3p, hsa-miR-532- 3p, hsa-miR-15b-3p 1883 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 78.96 79.7 81.67 197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1884 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.96 86.78 80 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p 1885 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.96 84.56 81.67 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1886 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.96 87.15 78.33 hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR- 18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 15b-3p 1887 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.96 86.39 81.67 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa- miR-532-3p 1888 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 78.96 82.61 83.33 197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR- 15b-3p 1889 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, 78.92 84.81 80 hsa-miR-423-5p, hsa-miR-326, hsa-miR-4306, hsa-miR- 664a-3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-532-3p 1890 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 78.92 86.52 80 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1891 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 78.87 86.83 80 hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-579-3p, hsa-miR-532-3p 1892 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p, 78.87 84.19 81.67 hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-18a-5p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa- miR-6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR-579-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1893 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 78.87 87.26 80 miR-197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p, hsa-miR-7-5p 1894 hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa- 78.79 87.35 76.67 miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR- 197-3p, hsa-miR-101-3p, hsa-miR-664a-3p, hsa-miR-494- 3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532- 3p, hsa-miR-15b-3p, hsa-miR-7-5p 1895 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 78.1 84.65 78.33 miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1896 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa- 78.1 80.59 83.33 miR-197-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1897 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-29c-5p, 78.1 84.06 85 hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1898 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p, 78.1 85.17 81.67 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-532-3p, hsa-miR-15b-3p 1899 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 78.1 86.63 76.67 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1900 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 78.05 84.43 83.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p 1901 hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa- 78.05 87.48 81.67 miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa- miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p 1902 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa- 78.01 84.5 78.33 miR-29c-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-323b-3p, hsa-miR-128- 3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p, hsa-miR-7-5p 1903 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 78.01 81.85 81.67 miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-361-5p, hsa-miR-15b-3p 1904 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.01 84.37 80 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 361-5p, hsa-miR-532-3p 1905 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 78.01 84.56 80 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 361-5p, hsa-miR-532-3p 1906 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p, 78.01 79.31 83.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-130a-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-361-5p 1907 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 78.01 87.3 80 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p 1908 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 78.01 86.22 80 miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579- 3p, hsa-miR-532-3p, hsa-miR-15b-3p 1909 hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 78.01 83.67 83.33 miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1910 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 77.97 85.43 81.67 hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 532-3p 1911 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 77.97 86.59 76.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- miR-197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-15b-3p, hsa-miR-7-5p 1912 hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa- 77.97 83.8 78.33 miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a- 3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-7-5p 1913 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p, 77.97 82.22 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p 1914 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa- 77.23 81.94 80 miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1915 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 77.14 80.06 81.67 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-323b-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1916 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-326, hsa-miR- 77.14 87.83 80 18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1917 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 77.14 85.41 81.67 miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR- 532-3p, hsa-miR-15b-3p 1918 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 77.14 83.43 78.33 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1919 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 77.14 87.31 76.67 miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1920 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 77.14 85.54 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1921 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 77.14 87.11 75 hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1922 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p, 77.14 85.56 78.33 hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa- miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa- miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-532-3p 1923 hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 77.1 84.44 80 miR-326, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-423- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa- miR-15b-3p, hsa-miR-7-5p 1924 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, 77.1 83.65 78.33 hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-197-3p, hsa- miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1925 hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 77.1 78.39 81.67 miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1926 hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-2110, hsa- 77.1 82.46 75 miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa- miR-579-3p, hsa-miR-15b-3p 1927 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, 77.06 89.8 78.33 hsa-miR-202-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-664a-3p, age, hsa-miR-361- 5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1928 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 77.06 85.72 76.67 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-101-3p, hsa- miR-130a-3p, hsa-miR-423-3p, hsa-miR-128-3p, hsa- miR-494-3p, age, hsa-miR-1260b, hsa-miR-15b-3p, hsa-miR-7-5p 1929 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 76.32 83.76 76.67 hsa-miR-326, hsa-miR-101-3p, hsa-miR-4306, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1930 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-326, hsa- 76.28 83.94 76.67 miR-197-3p, hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p, hsa-miR-7-5p 1931 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 76.23 83.78 80 hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a- 3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1932 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p, 76.23 82.54 81.67 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423- 3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa- miR-15b-3p 1933 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 76.23 84.09 78.33 hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR- 6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 361-5p, hsa-miR-15b-3p 1934 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p, 76.23 81.52 78.33 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 101-3p, hsa-miR-18a-5p, hsa-miR-6803-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 1260b, hsa-miR-532-3p, hsa-miR-7-5p 1935 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-423-5p, 76.23 80.96 81.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-15b-3p 1936 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 76.23 84.35 76.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b- 3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-15b-3p 1937 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa- 76.23 88.17 80 miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR- 1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1938 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 76.19 79.41 80 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-15b-3p 1939 hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, 76.15 80.65 80 hsa-miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa- miR-130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-128-3p, hsa-miR-361-5p 1940 hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p, 76.15 81.61 80 hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR- 197-3p, hsa-miR-423-3p, hsa-miR-323b-3p, hsa-miR- 15b-3p 1941 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p, 75.37 80.35 78.33 hsa-miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 664a-3p, hsa-miR-323b-3p, hsa-miR-361-5p, hsa-miR- 532-3p, hsa-miR-15b-3p 1942 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 75.28 75.44 80 197-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1943 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p, 75.28 81.57 78.33 hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa- miR-6803-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR- 15b-3p, hsa-miR-7-5p 1944 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR- 75.28 81.22 76.67 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR- 532-3p, hsa-miR-15b-3p 1945 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p, 75.28 82.94 80 hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1946 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 75.24 84.85 78.33 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR- 423-3p, hsa-miR-6803-3p, hsa-miR-128-3p, hsa-miR-361- 5p, hsa-miR-1260b, hsa-miR-7-5p 1947 hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa- 75.19 80.24 80 miR-326, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR- 130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-15b-3p, hsa-miR-7-5p 1948 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p, 75.19 80.83 78.33 hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-18a-5p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR- 128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-7-5p 1949 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 74.46 79.13 76.67 101-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1950 hsa-miR-30b-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR- 74.46 76.76 78.33 4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b- 3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p 1951 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 74.37 82.94 76.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-6803-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR- 15b-3p 1952 hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p, 74.37 81.44 76.67 hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-18a-5p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR- 6803-3p, hsa-miR-323b-3p, hsa-miR-361-5p, hsa-miR- 579-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1953 hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 74.37 84.28 76.67 197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803- 3p, hsa-miR-323b-3p, age, hsa-miR-361-5p, hsa-miR- 532-3p 1954 hsa-miR-202-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 74.37 80.87 80 miR-101-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR- 6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR- 494-3p, hsa-miR-1260b, hsa-miR-532-3p, hsa-miR-15b-3p 1955 hsa-miR-181c-3p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- 74.2 83.07 76.67 miR-326, hsa-miR-2110, hsa-miR-101-3p, hsa-miR-6803- 3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-miR-579-3p, hsa-miR-7-5p 1956 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa- 73.55 81.39 73.33 miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1957 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 73.51 78.74 76.67 hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa- miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803- 3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-15b-3p 1958 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p, 73.46 78.2 76.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa- miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-15b-3p 1959 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-1301-3p, 73.33 83.43 71.67 hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa- miR-130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa- miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR- 579-3p, hsa-miR-15b-3p, hsa-miR-7-5p 1960 hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa- 72.6 79.83 76.67 miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR- 15b-3p 1961 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 72.55 79.56 78.33 423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR- 128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532- 3p, hsa-miR-15b-3p 1962 hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p, 71.6 83.37 76.67 hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-197-3p, hsa- miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR- 4306, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494- 3p, age, hsa-miR-579-3p, hsa-miR-15b-3p 1963 hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p, 71.56 78.3 71.67 hsa-miR-2110, hsa-miR-101-3p, hsa-miR-18a-5p, hsa- miR-4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 128-3p, age, hsa-miR-532-3p 1964 hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR- 70.78 77.81 71.67 101-3p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR- 323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361- 5p, hsa-miR-532-3p, hsa-miR-15b-3p 1965 combination 1723 + rs71384446 63.38 64.5 85.97 1966 combination 1723 + rs11647727 53.46 57.78 80.70 1967 combination 1724 + rs71384446 61.52 59 84.27 1968 combination 1725 + rs7193058 71.6 71 81.58 1969 combination 1725 + rs11647727 70.74 70.13 84.15 1970 combination 1735 + rs13335818 78.01 85.35 81.58 1971 combination 1735 + rs7193058 78.87 89.7 85.1 1972 combination 1739 + rs9928757 80.74 87.02 84.19 1973 combination 1744 + rs11862974 81.69 90.7 84.19 1974 combination 1745 + rs11647727 81.65 90.72 90.00 1975 combination 1747 + rs76563024 81.65 88.28 85.2 1976 combination 1750 + rs13335818 83.46 91.35 90.3 1977 combination 1877 + rs76563024 79.78 90.31 89.35 1978 combination 1877 + rs76563024 79.78 90.31 90.45

This is the list of the best 29 mRNA selected by the algorithm sorted by importance for diagnosis outcome: hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for diagnosis (Table 25).

TABLE 25 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for diagnosis. N Combinations Accuracy ROCAUC Recall 1979 hsa-miR-550a-3-5p 70 74.38 82.44 1980 hsa-miR-550a-3-5p, hsa-miR-132-3p 78.33 81.83 88.89 1981 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p 80 82.06 95.78 1982 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 76.67 80.14 96.89 hsa-miR-590-5p 1983 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 78.33 81.39 90.89 hsa-miR-590-5p, hsa-miR-590-3p 1984 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 81.67 83.89 96.89 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 1985 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 81.67 80.65 97.78 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 1986 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 76.67 79.79 98.89 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p 1987 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 71.67 78.89 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 1988 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 78.33 84.4 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 1989 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 76.67 81.55 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p 1990 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 76.67 82.36 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p 1991 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 91.06 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p 1992 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 83.33 90.95 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p 1993 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 81.67 90.32 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l 1994 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 81.67 88.22 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p 1995 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 88.96 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p 1996 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 88.33 95.05 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age 1997 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 88.33 95.16 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p 1998 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 86.67 94.19 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p 1999 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 86.67 92.94 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p 2000 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 86.67 97.04 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136 2001 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 86.67 97.04 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p 2002 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 94.65 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p 2003 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 95.39 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p 2004 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 83.33 93.52 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p 2005 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 93.91 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p 2006 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 80 94.54 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p 2007 hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, 85 93.91 100.0 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p 2008 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 95 97.78 97.78 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2009 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 95 90.09 95.28 hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p 2010 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 95 95.56 97.78 age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2011 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 95 95.56 97.78 age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2012 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 95 95.56 97.78 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2013 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 95 95.56 97.78 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2014 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 96.3 95.56 age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2015 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 94.77 95 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-374a-5p 2016 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 93.45 95.28 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p 2017 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 93.33 94.81 97.78 hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2018 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 94.81 97.78 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2019 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 98.52 95.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2020 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 96.3 95.56 age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2021 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 95.56 95.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2022 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 93.45 95.28 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2023 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 96.3 95.56 age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2024 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 93.33 90.83 95.28 hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2025 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 94.81 95.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2026 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 93.33 94.81 97.78 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p 2027 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 94.81 95.56 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2028 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 93.33 93.06 97.78 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2029 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 96.3 95.28 hsa-miR-548l, age, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2030 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 93.33 91.57 95.28 hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2031 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 93.33 94.31 95.56 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2032 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 96.3 93.33 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2033 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 94.07 95.28 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2034 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 92.08 95.56 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p 2035 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 91.67 89.07 95 hsa-miR-103a-2-5p, hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p 2036 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 98.52 95.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2037 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 91.67 95.51 92.78 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2038 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 91.67 92.82 95.56 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p 2039 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 91.67 97.04 92.78 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2040 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 95.56 95.28 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2041 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 97.04 95.56 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2042 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 91.67 92.43 95.28 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2043 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 91.67 97.04 92.78 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2044 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 94.81 90.56 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2045 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 94.31 93.06 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2046 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 94.31 93.06 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2047 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 90 94.31 93.06 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2048 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 90 94.31 93.06 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2049 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 94.03 92.78 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2050 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 90 88.33 92.78 hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2051 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 90 92.31 90.28 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-374a-5p 2052 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 97.15 90.56 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2053 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 90 94.81 90.83 hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2054 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 90 97.78 90.56 hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2055 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, age, 90 91.85 90.83 hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2056 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 90 95.67 93.06 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2057 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 90 93.52 90.28 hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2058 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 97.04 95.28 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2059 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 98.63 92.78 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2060 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 88.84 91.11 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2061 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 92.43 95.28 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2062 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 94.81 93.06 age, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2063 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 97.78 92.78 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2064 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 92.71 90.56 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p 2065 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 90 95.56 93.33 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p 2066 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 90 88.96 92.78 hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2067 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, age, 88.33 95.79 95.28 hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2068 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 95.79 85.83 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2069 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 92.71 88.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2070 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 88.33 87.59 90.28 hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p 2071 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 92.94 93.06 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p 2072 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 96.41 93.06 age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2073 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 92.94 86.11 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2074 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 88.33 95.56 95.56 hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2075 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 96.41 93.06 age, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2076 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 90.83 90.56 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-3p 2077 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 88.33 95.9 88.33 hsa-miR-29c-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2078 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 97.27 90.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2079 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 88.33 95.67 88.06 hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-337-5p 2080 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 89 88.33 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-590-3p 2081 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 98.63 90.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2082 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 90.72 90.83 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2083 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 86.9 90.83 hsa-miR-548l, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-590-3p 2084 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 91.85 92.78 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2085 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 88.33 90.56 90.56 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-500a-5p 2086 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 88.33 95.05 85.56 hsa-miR-103a-2-5p, hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2087 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 92.08 92.78 age, hsa-miR-192-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2088 hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-192-5p, 88.33 94.19 93.06 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2089 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 93.06 95.28 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2090 hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-181b-5p, 88.33 94.07 92.78 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2091 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 93.06 88.33 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2092 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 96.3 86.67 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2093 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 97.38 88.06 hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2094 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 91.11 88.61 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2095 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-548l, 88.33 95.67 88.33 hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2096 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 88.33 91.69 92.78 hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2097 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 93.68 90.56 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2098 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 88.33 93.91 88.33 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2099 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 88.33 96.3 92.78 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2100 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 88.33 92.82 90.83 age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2101 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.56 88.61 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2102 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.71 88.89 age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2103 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 86.67 93.45 85.83 hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-374a-5p, hsa-miR-130b-5p 2104 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.68 84.17 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2105 hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-192-5p, 86.67 93.45 93.06 hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2106 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 88.22 88.06 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2107 hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-192-5p, 86.67 94.19 90.83 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2108 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 89.24 88.33 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2109 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.59 88.89 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2110 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.45 86.11 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2111 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 91.46 86.39 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2112 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 90.83 85.56 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2113 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 86.67 94.07 83.89 hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2114 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 91.57 86.11 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2115 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 88.73 95.28 age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p 2116 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 86.67 95.51 90.56 hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2117 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 82.25 93.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2118 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.66 88.06 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2119 hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, 86.67 94.81 85.83 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2120 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 86.67 95.28 87.78 hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2121 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 86.16 88.89 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p 2122 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 87.36 92.78 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2123 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 88.38 92.5 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p 2124 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 91.57 88.33 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2125 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 84.12 90 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p 2126 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 91.57 87.78 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2127 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.43 88.06 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2128 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.71 88.06 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p 2129 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 86.67 89.63 88.61 hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-500a-5p 2130 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 92.2 88.33 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2131 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.8 88.33 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p 2132 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 91.81 87.78 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-374a-5p 2133 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 96.41 83.61 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2134 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 86.67 92.15 85.56 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2135 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.33 86.39 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2136 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 95.67 86.39 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2137 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 86.67 91.57 95.28 hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2138 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 86.67 94.93 88.61 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2139 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 96.41 88.33 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2140 hsa-miR-4732-5p, hsa-miR-1277-3p, age, hsa-miR-192-5p, 86.67 96.41 87.78 hsa-miR-12136, hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2141 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 93.56 85.83 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2142 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 86.67 87.41 88.61 hsa-miR-548l, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p 2143 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-29c-5p, 86.67 92.2 86.11 age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2144 hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 86.67 93.33 88.61 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2145 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 85 92.43 88.61 hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2146 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 85 91.11 92.78 hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2147 hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-192-5p, 85 90.72 88.33 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-500a-5p 2148 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 88.22 88.61 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-99a-3p, hsa-miR-337-5p 2149 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 85 88.45 88.33 hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2150 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 92.94 83.89 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2151 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 85 90.21 90.56 hsa-miR-12136, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2152 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 88.56 93.06 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2153 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 94.81 87.78 age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2154 hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-628-3p, 85 86.85 90.83 hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2155 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 93.06 93.06 age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2156 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 87.36 88.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2157 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 94.81 87.78 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2158 hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, age, 85 93.56 90.28 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2159 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p, 85 84.75 85.83 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p 2160 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 85 91.3 81.39 hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2161 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-192-5p, 85 94.07 86.67 hsa-miR-598-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2162 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 91.97 88.33 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p 2163 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 92.71 88.33 age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2164 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 92.59 86.11 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-130b-5p 2165 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 92.43 88.06 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2166 hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-196b-5p, 85 91.57 88.33 hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2167 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 91.57 85.28 hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-374a-5p 2168 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-181b-5p, 85 92.31 88.33 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2169 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 87.41 86.11 hsa-miR-548l, age, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-3p 2170 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 90.95 86.11 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2171 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 85 87.48 90.83 hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2172 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 85 89.24 88.06 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2173 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 85 87.94 81.11 hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2174 hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 85 97.78 83.61 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p 2175 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 83.33 92.82 81.39 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p, hsa-miR-337-5p 2176 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 94.81 85.28 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2177 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 92.08 86.39 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2178 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 84.56 86.67 hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2179 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-1277-3p, 83.33 88.29 81.11 hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p, hsa-miR-337-5p 2180 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 83.33 90.09 83.33 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p 2181 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 93.29 85.56 hsa-miR-548l, age, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2182 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 86 85.83 hsa-miR-548l, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p 2183 hsa-miR-4732-5p, hsa-miR-29c-5p, hsa-miR-433-3p, 83.33 90.44 83.61 hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2184 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, 83.33 90.49 81.39 hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2185 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p, 83.33 91.34 85.83 hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-590-3p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2186 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 91.46 83.89 hsa-miR-29c-5p, age, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2187 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 91.23 86.39 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p, hsa-miR-99a-3p, hsa-miR-130b-5p 2188 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 90.09 85.56 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2189 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 83.33 90.83 80.83 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2190 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 83.33 91.06 86.11 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2191 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 91.06 84.17 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2192 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 83.33 88.06 83.33 hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2193 hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, 83.33 84 90.56 hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2194 hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-1277-3p, 83.33 89.98 88.61 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-337-5p 2195 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 91.81 83.33 hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p 2196 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 83.33 92.08 88.33 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2197 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 87.36 90.56 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p 2198 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 83.33 90.83 88.33 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2199 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 83.33 89.47 88.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2200 hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-628-3p, 83.33 88.26 88.89 hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2201 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 89.86 84.17 hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2202 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 89.58 85.56 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2203 hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-433-3p, 81.67 87.59 81.39 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2204 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 90.83 83.89 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2205 hsa-miR-4732-5p, hsa-miR-192-5p, hsa-miR-122-5p, 81.67 86.74 85.56 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2206 hsa-miR-4732-5p, hsa-miR-196b-5p, hsa-miR-215-5p, 81.67 87.48 85.83 hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2207 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 81.67 91.46 88.33 hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2208 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 81.67 86.74 85.83 hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2209 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 83.96 85.56 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2210 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p, 81.67 88.45 81.11 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-337-5p 2211 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p, 81.67 88.33 80.83 hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2212 hsa-miR-374a-3p, hsa-miR-548l, hsa-miR-1277-3p, 81.67 83.56 79.17 hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-433-3p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p 2213 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-548l, 81.67 84.24 83.61 hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p 2214 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 88.1 85.56 hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2215 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 82.01 90.56 age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2216 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-29c-5p, 81.67 87.13 86.67 age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-99a-3p, hsa-miR-130b-5p 2217 hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-29c-5p, age, 81.67 91.11 86.67 hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2218 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 90.09 88.61 hsa-miR-548l, hsa-miR-29c-5p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-99a-3p 2219 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 81.67 90.44 79.17 hsa-miR-29c-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2220 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p, 81.67 88.96 83.33 hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2221 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 81.67 88.73 88.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2222 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 80 86 83.61 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-500a-5p 2223 hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, age, 80 88.61 88.06 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2224 hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-628-3p, 80 83.61 79.17 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2225 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 80 90.95 81.39 hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2226 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, 80 86 83.33 hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-500a-5p 2227 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 80 89.98 81.39 hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2228 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-122-5p, 80 86.34 87.78 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2229 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 80 86.27 74.72 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2230 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 80 90.32 88.33 hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2231 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 80 76.39 85.83 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p 2232 hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-433-3p, 80 83.15 83.89 hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2233 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 80 84.86 78.89 hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-433-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2234 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p, 80 89.58 88.33 hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2235 hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l, 80 87.31 78.89 hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p, hsa-miR-337-5p 2236 hsa-miR-4732-5p, hsa-miR-122-5p, hsa-miR-196b-5p, 80 89.58 88.06 hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2237 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-122-5p, 80 85.72 85.83 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p 2238 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p, 78.33 86.39 83.89 hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p 2239 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 78.33 84.86 79.44 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2240 hsa-miR-374a-3p, hsa-miR-548l, age, hsa-miR-181b-5p, 78.33 82.31 81.11 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2241 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 78.33 89.58 79.17 hsa-miR-29c-5p, age, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2242 hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-122-5p, 78.33 88.73 86.11 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2243 hsa-miR-4732-5p, age, hsa-miR-122-5p, hsa-miR-196b-5p, 78.33 87.94 80.83 hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2244 hsa-miR-374a-3p, hsa-miR-548l, hsa-miR-1277-3p, 78.33 87.2 76.67 hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2245 hsa-miR-374a-3p, hsa-miR-1277-3p, hsa-miR-29c-5p, 78.33 79.58 81.39 hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-130b-5p 2246 hsa-miR-4732-5p, hsa-miR-628-3p, hsa-miR-122-5p, 78.33 79.56 83.33 hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p 2247 hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-29c-5p, 78.33 82.25 83.06 age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p 2248 hsa-miR-374a-3p, hsa-miR-1277-3p, hsa-miR-181b-5p, 76.67 83.5 81.67 hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-374a-5p, hsa-miR-99a-3p 2249 hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-29c-5p, 76.67 81.27 76.39 hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p 2250 hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-181b-5p, 76.67 81.83 78.89 hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2251 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l, 76.67 83.38 76.67 hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-337-5p 2252 hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, 76.67 79.33 79.17 hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2253 hsa-miR-4732-5p, hsa-miR-628-3p, hsa-miR-196b-5p, 73.33 81.55 79.17 hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p 2254 hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-1277-3p, 73.33 82.29 76.94 age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p 2255 combinazione1979+rs71384446 73.33 80.07 80.07 2256 combinazione1979+rs76563024 71.67 76.88 76.88 2257 combinazione1980+rs7204342 83.33 81.71 81.71 2258 combinazione1980+rs7193058 73.33 77.57 77.57 2259 combinazione1982+rs4297685 81.67 83.26 83.26 2260 combinazione1982+rs4297685 80 84.75 84.75 2261 combinazione1983+rs4297685 80 82.01 82.01 2262 combinazione1934+rs28640218 83.33 80.02 80.02 2263 combinazione1985+rs13335818 83.33 83.03 83.03 2264 combinazione1986+rs13335818 76.67 78.26 78.26 2265 combinazione1987+rs76563024 75 79.91 79.91 2266 combinazione1993+rs11647727 85 87.64 87.64 2267 combinazione1994+rs4297685 85 85.76 85.76 2268 combinazione1995+rs13333226 88.33 91.57 91.57 2269 combinazione2006+rs13333226 80 84.24 84.24

This is the list of the best 30 miRNA selected by the algorithm sorted by importance for tumour stage: hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour stage (Table 26).

TABLE 26 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for tumour stage. N Combinations Accuracy ROC AUC Recall 2270 hsa-miR-769-5p 81.67 80 74.44 2271 hsa-miR-769-5p, hsa-miR-548a-3p 81.67 84.29 72.5 2272 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p 83.89 90 85.83 2273 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.89 95.71 86.11 miR-190a-5p 2274 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.39 91.43 93.33 miR-190a-5p, hsa-miR-215-5p 2275 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 95.71 91.39 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p 2276 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 81.67 95.71 96.39 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p 2277 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 83.89 94.29 96.11 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421 2278 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.61 91.43 99.17 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p 2279 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 94.29 98.06 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2280 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.33 95.71 100.0 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p 2281 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.33 90 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p 2282 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 90.83 95.71 97.78 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p 2283 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.33 98.57 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p 2284 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 98.57 100.0 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p 2285 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 83.61 98.57 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p 2286 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.39 98.57 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941 2287 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 85.83 97.14 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p 2288 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 83.33 97.14 97.78 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p 2289 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 81.11 97.14 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p 2290 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 81.11 97.14 98.89 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p 2291 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 83.33 97.14 100.0 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p 2292 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 94.29 100.0 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p 2293 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 92.86 99.17 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p 2294 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 92.86 99.17 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-100-5p 2295 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 86.11 90 99.17 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p 2296 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 85.83 91.43 99.17 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR- 323b-3p 2297 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 85.83 94.29 97.22 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR- 323b-3p, hsa-miR-452-3p 2298 hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa- 88.33 91.43 97.22 miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa- miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR- 30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa- miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR- 323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p 2299 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 100 100 100 miR-941, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR- 1296-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR- 215-5p, hsa-miR-324-3p, hsa-miR-143-3p 2300 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR- 215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2301 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR- 1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143- 3p, hsa-miR-421 2302 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa- 100 100 100 miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa- miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR- 421, hsa-miR-22-5p 2303 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR- 1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421 2304 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i- 5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa- miR-143-3p, hsa-miR-421 2305 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 100 100 100 miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296- 5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2306 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p, 100 100 100 hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa- miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p, hsa- miR-215-5p, hsa-miR-143-3p, hsa-miR-421 2307 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR- 1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-421 2308 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 100 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i- 5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-1301- 3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2309 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p, 97.78 100 100 hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa- miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa- miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR- 421 2310 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR- 1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143- 3p, hsa-miR-421 2311 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140- 3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p 2312 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 97.78 100 100 miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR- 1301-3p, hsa-miR-324-3p, hsa-miR-421 2313 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR- 1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421 2314 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa- 97.78 100 100 miR-32-3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i- 5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-143-3p, hsa-miR-421, hsa- miR-22-5p, hsa-miR-4306 2315 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-941, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-30e- 5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p 2316 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-941, hsa-miR- 97.78 100 100 30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b- 3p, hsa-miR-452-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2317 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 97.78 100 90 miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR- 1301-3p, hsa-miR-324-3p, hsa-miR-421 2318 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-503- 5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p 2319 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i- 5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa- miR-421 2320 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 90 miR-664a-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa- miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa- miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR- 421 2321 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 97.78 100 100 miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296- 5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2322 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 90 miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR- 452-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421 2323 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-941, hsa-miR- 97.78 100 100 30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b- 3p, hsa-miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2324 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa- 97.78 97.14 100 miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p 2325 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.78 100 90 miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR- 323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR- 324-3p, hsa-miR-143-3p, hsa-miR-421 2326 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 97.5 100 100 miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296- 5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa- miR-421 2327 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.5 100 100 miR-664a-3p, hsa-miR-941, hsa-miR-503-5p, hsa-miR- 30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR- 323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR- 324-3p, hsa-miR-421 2328 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 97.5 100 80 miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR- 324-3p, hsa-miR-143-3p, hsa-miR-421 2329 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 97.5 100 100 miR-664a-3p, hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR- 30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-421 2330 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa- 97.5 97.14 100 miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR- 30e-5p, hsa-miR-1296-5p, 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hsa-miR-452-3p, hsa-miR- 190a-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2515 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 86.11 94.29 50 miR-664a-3p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa- miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa- miR-215-5p, hsa-miR-143-3p 2516 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 86.11 92.86 60 miR-31-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR- 181c-5p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-22- 5p 2517 hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 86.11 95.71 100 miR-503-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR- 215-5p, hsa-miR-324-3p, hsa-miR-421 2518 hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 86.11 98.57 60 miR-503-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR- 100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR- 215-5p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p 2519 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 86.11 95.71 80 miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-100- 5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301- 3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2520 hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR- 85.83 90 80 32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e- 5p, hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa- miR-143-3p, hsa-miR-22-5p, hsa-miR-4306 2521 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa- 85.83 91.43 100 miR-32-3p, hsa-miR-140-3p, hsa-miR-181c-5p, hsa-miR- 323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR- 215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2522 hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 85.83 94.29 100 miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR- 30e-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452- 3p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR- 22-5p 2523 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 85.83 94.29 100 miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32- 3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa- miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa- miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa- miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR- 421, hsa-miR-4306 2524 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p, 85.83 100 100 hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let- 7i-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301- 3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306 2525 hsa-miR-106b-3p, hsa-miR-941, hsa-miR-140-3p, hsa- 85.83 90 70 miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR- 20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR- 215-5p, hsa-miR-143-3p, hsa-miR-421 2526 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p, 84.44 91.43 80 hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR- 323b-3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR- 143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2527 hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 84.17 91.43 70 miR-503-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR- 181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR- 1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p 2528 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 84.17 91.43 80 miR-664a-3p, hsa-miR-32-3p, hsa-miR-30e-5p, hsa-miR- 1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR- 20b-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324- 3p, hsa-miR-143-3p, hsa-miR-421 2529 hsa-miR-132-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa- 84.17 94.29 70 let-7i-5p, hsa-miR-452-3p, hsa-miR-421, hsa-miR-22-5p 2530 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p, 83.89 94.29 100 hsa-miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR- 100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR- 190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143- 3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2531 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 83.89 97.14 80 miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-100- 5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421 2532 hsa-miR-335-5p, hsa-miR-941, hsa-miR-503-5p, hsa-miR- 83.89 92.86 70 30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-452-3p, hsa-miR-215-5p, hsa-miR-421 2533 hsa-miR-132-3p, hsa-miR-664a-3p, hsa-miR-503-5p, hsa- 83.89 88.57 60 let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR- 181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR- 20b-5p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306 2534 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 83.61 88.57 80 miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR- 140-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249- 3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-143-3p, hsa-miR-421 2535 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa- 83.61 88.57 100 miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140- 3p, hsa-miR-1249-3p, hsa-miR-181c-5p, hsa-miR-323b- 3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-22-5p, hsa- miR-4306 2536 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa- 83.61 90 60 miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140- 3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-143-3p 2537 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 81.67 92.86 90 miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR- 140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa- miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa- miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306 2538 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-503-5p, hsa- 81.67 82.86 40 miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR- 1249-3p, hsa-miR-323b-3p 2539 hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 81.67 90 90 miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140- 3p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa- miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22- 5p, hsa-miR-4306 2540 hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa- 81.39 91.43 50 miR-664a-3p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR- 1296-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR- 323b-3p, hsa-miR-215-5p, hsa-miR-143-3p 2541 hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa- 81.11 94.29 70 miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503- 5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa- miR-143-3p, hsa-miR-22-5p 2542 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa- 81.11 87.14 80 miR-31-5p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR- 1249-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-421 2543 hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR- 79.44 94.29 70 32-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR- 4306 2544 hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p, 76.94 85.71 70 hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa- miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p, hsa- miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22- 5p, hsa-miR-4306 2545 combination 2272 + rs12917707 84.17 80 53.33 2546 combination 2274 + rs9928757 84.44 90 63.33 2547 combination 2275 + rs13335818 91.11 95.71 71.67 2548 combination 2276 + rs13335818 88.61 94.29 78.33 2549 combination 2277 + rs76563024 88.89 95.71 81.67 2550 combination 2278 + rs4297685 86.67 94.29 93.33 2551 combination 2279 + rs9928757 88.89 92.86 91.39 2552 combination 2280 + rs71384446 91.11 97.14 96.39 2553 combination 2281 + rs13333226 93.33 98.57 96.11 2554 combination 2282 + rs7204342 93.33 100 100 2555 combination 2283 + rs11862974 90.83 95.71 99.17 2556 combination 2284 + rs13335818 93.33 98.57 98.06 2557 combination 2285 + rs13335818 93.33 98.57 100.0 2558 combination 2286 + rs13333226 88.89 100 100 2559 combination 2287 + rs13333226 90.83 95.71 93.33 2560 combination 2288 + rs13335818 93.06 95.71 91.39 2561 combination 2289 + rs4297685 88.33 94.29 96.39 2562 combination 2290 + rs76563024 88.33 94.29 96.11 2563 combination 2291 + rs71384446 86.11 94.29 99.17 2564 combination 2292 + rs71384446 86.11 94.29 98.06 2565 combination 2293 + rs71384446 95 94.29 100.0 2566 combination 2294 + rs11647727 95 94.29 98.89 2567 combination 2295 + rs11647727 92.78 92.86 97.78 2568 combination 2296 + rs11647727 92.78 92.86 98.89 2569 combination 2297 + rs13335818 87.78 90 98.89 2570 combination 2528 + rs12934455 85.28 90 98.89 2571 combination 2529 + rs12934455 85.28 90 98.89 2572 combination 2274 + rs4293393 88.61 91.43 97.78 2573 combination 2275 + rs4293393 91.11 95.71 98.89 2574 combination 2277 + rs4293393 88.89 94.29 98.89 2575 combination 2278 + rs4293393 91.11 94.29 100.0 2576 combination 2279 + rs4293393 86.67 90 100.0 2577 combination 2280 + rs4293393 88.61 88.57 99.17 2578 combination 2282 + rs4293393 90.83 94.29 99.17 2579 combination 2283 + rs4293393 92.78 94.29 99.17 2580 combination 2287 + rs4293393 90.56 95.71 99.17 2581 combination 2288 + rs4293393 90.56 92.86 97.22 2582 combination 2289 + rs4293393 90.56 95.71 97.22 2583 combination 2290 + rs4293393 90.56 92.86 91.39 2584 combination 2292 + rs4293393 95.28 97.14 96.39 2585 combination 2293 + rs4293393 92.78 95.71 96.11 2586 combination 2294 + rs4293393 90.56 95.71 99.17 2587 combination 2295 + rs4293393 90.56 94.29 98.06 2588 combination 2296 + rs4293393 88.06 91.43 93.33 2589 combination 2297 + rs4293393 88.06 91.43 91.39

This is the list of the best 30 mRNA selected by the algorithm sorted by importance for tumour grade: hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour grade (Table 27).

TABLE 27 Combinations that allow higher sensitivity, specificity, accuracy and predictive power for tumour grade. N Combinations Accuracy ROC AUC Recall 2590 hsa-miR-4306 76.67 74.76 58.57 2591 hsa-miR-4306, hsa-miR-132-3p 70 63.33 76.40 2592 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p 79.17 80.79 85.51 2593 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 86.11 88.65 87.24 miR-148a-3p 2594 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 83.89 84.92 89.21 miR-148a-3p, hsa-miR-629-5p 2595 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 93.06 96.9 89.43 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p 2596 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.56 96.9 88.79 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p 2597 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.56 93.81 83.31 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p 2598 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.83 95.24 89.77 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2599 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.56 100 91.19 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p 2600 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 93.06 98.33 92.39 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p 2601 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.83 98.57 92.61 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p 2602 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 86.39 95.24 95.90 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p 2603 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 85.83 95 95.84 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p 2604 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 86.39 93.81 97.10 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p 2605 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.56 95.24 96.40 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p 2606 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 92.78 95.24 99.11 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p 2607 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.56 98.57 99.11 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p 2608 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 90.83 93.81 99.14 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p 2609 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 88.33 92.62 98.52 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p 2610 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 93.06 94.29 98.83 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p 2611 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 81.11 92.38 100.00 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p 2612 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 81.39 93.81 100.00 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p 2613 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 81.39 92.14 100.00 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p 2614 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 88.33 90.48 98.77 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p, hsa-miR-340-5p 2615 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 88.33 90.48 97.85 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p 2616 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 83.89 90.71 97.23 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p 2617 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 83.61 86.19 97.57 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p 2618 hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa- 83.89 87.62 97.26 miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR- 1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b- 3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p 2619 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 97.78 98.57 100.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-590-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-let-7i-5p 2620 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 97.78 97.14 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2621 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 97.78 100.00 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-1296-5p, hsa-let-7i-5p 2622 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 97.78 98.57 100.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i- 5p 2623 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 97.78 100.00 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-let-7i-5p 2624 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 95.56 97.46 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2625 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 95.56 97.46 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2626 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 95.56 98.89 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-let-7i-5p, hsa-miR-652-5p 2627 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 95.56 97.46 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2628 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 95.56 93.17 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-miR-1296-5p, hsa-let-7i- 5p, hsa-miR-652-5p 2629 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 95.56 97.46 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-let-7i-5p 2630 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 95.56 97.46 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-let-7i-5p, hsa-miR-652-5p 2631 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 95.56 100.00 90.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2632 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 95.56 98.57 100.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR- 433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a- 3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2633 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 95.56 98.57 90.00 miR-202-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-652- 5p 2634 hsa-miR-424-5p, hsa-miR-202-5p, hsa-miR-410-3p, hsa- 95.56 100.00 90.00 miR-584-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR- 433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a- 3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2635 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 95.28 98.57 90.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-miR- 545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i- 5p 2636 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa- 95.28 98.57 80.00 miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2637 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 95.28 100.00 90.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-let-7i-5p, hsa-miR-652-5p 2638 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 95.28 96.67 90.00 miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa- miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2639 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 95.28 98.57 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-545-5p, hsa-let-7i-5p 2640 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 95.28 98.33 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p, hsa-miR-545-5p 2641 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa- 95.00 98.33 90.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-150-5p, hsa-miR- 590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-29c- 5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2642 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-1537-3p, hsa- 95.00 98.33 80.00 miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR- 505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a- 3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-652-5p 2643 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 93.33 96.35 93.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-590-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2644 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 98.57 83.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2645 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 92.86 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-15a- 3p, hsa-miR-1296-5p, hsa-let-7i-5p 2646 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 95.71 90.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR- 433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p 2647 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 93.33 96.03 93.33 miR-202-5p, hsa-miR-744-5p, hsa-miR-433-3p, hsa-miR- 148a-3p, hsa-miR-629-5p 2648 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 93.33 91.43 90.00 miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p 2649 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 92.86 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p 2650 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.33 91.43 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-433- 3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa- miR-652-5p 2651 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 98.57 83.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 1296-5p, hsa-let-7i-5p 2652 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.33 97.14 93.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-148a-3p, hsa-let-7i-5p 2653 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.33 97.14 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2654 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.33 98.57 83.33 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2655 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.33 91.43 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-29c- 5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p 2656 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.33 94.29 90.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-148a-3p 2657 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 93.33 97.14 90.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-let-7i-5p 2658 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.06 93.81 100.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa- miR-590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-629- 5p, hsa-miR-545-5p, hsa-miR-652-5p 2659 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.06 98.89 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-545-5p 2660 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.06 98.57 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p 2661 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 93.06 94.05 90.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-29b-3p, hsa-miR- 15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-1296- 5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2662 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa- 93.06 91.90 90.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-590-5p, hsa-miR- 340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-148a- 3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p 2663 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 93.06 95.71 80.00 miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 148a-3p, hsa-miR-652-5p 2664 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 93.06 100.00 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p 2665 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 93.06 98.89 83.33 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 545-5p 2666 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 93.06 100.00 100.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR- 15a-3p, hsa-let-7i-5p 2667 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 92.78 96.90 80.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a- 3p, 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hsa-miR-202-5p, hsa- 92.50 93.33 80.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-29b-3p, hsa-miR- 590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-148a- 3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p 2673 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 91.11 92.86 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a- 5p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p 2674 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 91.11 91.43 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2675 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 91.11 94.60 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-miR-340- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2676 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 91.11 91.43 100.00 miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-let-7i-5p 2677 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 91.11 91.43 100.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-15a- 3p, hsa-let-7i-5p 2678 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 91.11 91.43 93.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-3p, hsa-miR- 1296-5p, hsa-let-7i-5p 2679 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.83 95.48 70.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p 2680 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 90.83 94.92 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-433- 3p, hsa-let-7i-5p 2681 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.83 97.14 80.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p 2682 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.83 92.62 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-150-5p, hsa-miR-590-5p, hsa-miR-340- 5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-652-5p 2683 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 90.83 95.24 83.33 miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-103a- 2-5p 2684 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 90.83 95.71 80.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2685 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 90.83 93.17 93.33 miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-340-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 629-5p, hsa-let-7i-5p 2686 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 90.83 92.70 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-150-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-629-5p 2687 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 90.83 93.49 90.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 15a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p 2688 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.83 97.46 83.33 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 545-5p, hsa-let-7i-5p 2689 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 90.83 97.22 83.33 miR-34a-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-miR- 590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2690 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 93.81 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2691 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 95.48 90.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-let-7i-5p 2692 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 98.57 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c- 5p, hsa-miR-15a-3p, hsa-let-7i-5p 2693 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 95.48 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-15a- 3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2694 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 90.56 98.33 80.00 miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545- 5p, hsa-let-7i-5p, hsa-miR-652-5p 2695 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 90.56 95.48 80.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa-miR-103a-2- 5p, hsa-let-7i-5p 2696 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 90.56 98.57 80.00 miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2697 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 90.56 94.13 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-150-5p, hsa-miR-433-3p, hsa-miR-15a- 3p 2698 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 90.56 96.90 90.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a- 3p, hsa-let-7i-5p 2699 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 90.56 95.00 90.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 629-5p, hsa-miR-545-5p 2700 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 95.48 80.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2701 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.56 95.48 80.00 miR-744-5p, hsa-miR-1537-3p, hsa-miR-340-5p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 545-5p 2702 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 90.56 95.48 80.00 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2703 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 90.56 97.14 70.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 148a-3p, hsa-miR-652-5p 2704 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-410-3p, hsa- 90.28 92.14 90.00 miR-150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-148a-3p, hsa-miR-629- 5p, hsa-miR-545-5p, hsa-miR-652-5p 2705 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 90.28 95.24 80.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2706 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 90.28 93.33 70.00 miR-34a-5p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p 2707 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.89 90.00 93.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-let-7i-5p 2708 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.89 96.35 86.67 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-miR-545-5p, hsa-let-7i-5p 2709 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.89 91.43 100.00 miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-let-7i-5p 2710 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.89 92.86 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p 2711 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.61 98.57 100.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-629-5p 2712 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.61 97.14 80.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p 2713 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 88.61 91.19 90.00 miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-15a-3p, hsa-miR- 103a-2-5p, hsa-let-7i-5p 2714 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.61 88.41 90.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-629-5p 2715 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 88.61 96.03 76.67 miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR- 505-5p, hsa-miR-433-3p, hsa-miR-1296-5p, hsa-let-7i-5p 2716 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 88.61 91.43 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-629-5p 2717 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 88.61 97.14 83.33 miR-34a-5p, hsa-miR-32-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-505- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-let-7i-5p 2718 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.61 97.46 83.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR- 148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2719 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-664a-3p, hsa- 88.61 86.90 80.00 miR-1537-3p, hsa-miR-150-5p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-505-5p, hsa-miR-29c-5p, hsa-miR- 1296-5p, hsa-let-7i-5p 2720 hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 88.61 95.48 83.33 miR-410-3p, hsa-miR-664a-3p, hsa-miR-29b-3p, hsa- miR-629-5p, hsa-miR-1296-5p, hsa-let-7i-5p 2721 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.61 93.25 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR- 584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-340- 5p, hsa-miR-15a-3p, hsa-let-7i-5p 2722 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 88.33 97.14 70.00 miR-744-5p, hsa-miR-29b-3p, hsa-miR-505-5p, hsa-miR- 433-3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-miR- 103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p 2723 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 88.33 95.48 80.00 miR-34a-5p, hsa-miR-32-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-590- 5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2724 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.33 93.81 83.33 miR-202-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545- 5p 2725 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa- 88.33 94.68 73.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2726 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 88.33 91.43 70.00 miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa- miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR- 15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a- 3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2- 5p, hsa-let-7i-5p, hsa-miR-652-5p 2727 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 88.33 92.14 83.33 miR-410-3p, hsa-miR-744-5p, hsa-miR-15a-5p, hsa-miR- 433-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-let-7i-5p 2728 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.33 90.95 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-29c- 5p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2729 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.33 93.81 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2730 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.33 92.62 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-103a-2- 5p, hsa-let-7i-5p 2731 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.33 93.81 80.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, 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hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-652- 5p 2736 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 88.06 91.90 80.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p, hsa-miR-545-5p 2737 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 88.06 95.56 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-5p 2738 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 88.06 91.90 90.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-629-5p, hsa-miR-545-5p 2739 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa- 87.78 91.11 70.00 miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-let-7i- 5p 2740 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 87.78 93.81 90.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-let-7i-5p 2741 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa- 86.39 98.89 83.33 miR-1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR- 433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2742 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa- 86.39 96.11 76.67 miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR- 505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2743 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 86.39 91.19 86.67 miR-584-5p, hsa-miR-744-5p, hsa-miR-433-3p, hsa-miR- 15a-3p 2744 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 86.39 88.10 90.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p 2745 hsa-miR-369-3p, hsa-miR-410-3p, hsa-miR-664a-3p, hsa- 86.39 84.84 73.33 miR-744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-340-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR- 1296-5p, hsa-let-7i-5p, hsa-miR-652-5p 2746 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 86.39 90.32 80.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR- 590-5p, hsa-miR-340-5p, hsa-miR-29c-5p, hsa-miR-15a- 3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p 2747 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 86.39 92.14 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-let-7i-5p 2748 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa- 86.39 94.92 83.33 miR-1537-3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa- miR-15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR- 652-5p 2749 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 86.11 95.71 80.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 29b-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545- 5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2750 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 86.11 92.62 70.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 29b-3p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-miR- 103a-2-5p, hsa-let-7i-5p 2751 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 86.11 94.37 73.33 miR-32-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p 2752 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 86.11 90.95 80.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a- 5p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2753 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 86.11 90.95 90.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR- 629-5p 2754 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 86.11 96.35 66.67 miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR- 664a-3p, hsa-miR-1537-3p, hsa-miR-340-5p, hsa-miR- 15a-3p, hsa-miR-545-5p, hsa-let-7i-5p 2755 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 86.11 92.62 70.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-652-5p 2756 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa- 86.11 96.67 73.33 miR-1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR- 433-3p, hsa-miR-15a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2757 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 86.11 96.03 63.33 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR- 148a-3p, hsa-let-7i-5p 2758 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa- 86.11 94.13 66.67 miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p 2759 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 86.11 95.48 90.00 miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-505-5p, hsa-miR-148a-3p, hsa-miR-629- 5p, hsa-miR-545-5p 2760 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 86.11 91.19 70.00 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a- 5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-103a-2- 5p, hsa-let-7i-5p 2761 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 86.11 92.38 90.00 miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-let-7i-5p 2762 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 86.11 90.63 73.33 miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR- 433-3p, hsa-miR-15a-3p 2763 hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa- 86.11 92.38 70.00 miR-584-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR- 505-5p, hsa-miR-433-3p, 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hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629- 5p, hsa-miR-545-5p, hsa-let-7i-5p 2773 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 85.83 95.56 73.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-545-5p 2774 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 85.83 86.27 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-miR-652-5p 2775 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 85.83 91.27 73.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-340- 5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-629-5p 2776 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 85.83 93.81 70.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-103a- 2-5p, hsa-let-7i-5p 2777 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 85.83 89.92 83.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629- 5p, hsa-let-7i-5p 2778 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 85.56 89.05 70.00 miR-32-3p, hsa-miR-202-5p, hsa-miR-664a-3p, hsa-miR- 150-5p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p 2779 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 85.56 93.57 73.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a- 3p, hsa-let-7i-5p 2780 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 85.56 93.57 83.33 miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545- 5p 2781 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 85.56 84.92 60.00 miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i- 5p 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hsa-miR- 148a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652- 5p 2802 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 83.89 86.43 83.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-590-5p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-652-5p 2803 hsa-miR-128-3p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- 83.89 92.14 63.33 miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-let-7i-5p 2804 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 83.89 94.44 66.67 miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433- 3p, hsa-miR-15a-3p, hsa-let-7i-5p 2805 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 83.89 90.95 83.33 miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-433- 3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-let-7i-5p 2806 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 83.89 96.67 73.33 miR-202-5p, 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hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 83.33 90.48 70.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-433- 3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2816 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 83.33 91.03 70.00 miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR- 410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744- 5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa- let-7i-5p 2817 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 83.33 89.13 73.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p, hsa-miR-545-5p, hsa-let-7i-5p 2818 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 81.94 86.51 83.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-29c- 5p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-let-7i-5p, hsa- miR-652-5p 2819 hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 81.67 83.57 60.00 miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-340-5p, hsa-miR-29c-5p, hsa-miR- 148a-3p, hsa-miR-652-5p 2820 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa- 81.67 89.05 66.67 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let- 7i-5p 2821 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 81.67 92.62 73.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR- 744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a- 5p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-miR-103a-2- 5p, hsa-let-7i-5p 2822 hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 81.67 90.95 56.67 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-433-3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa- let-7i-5p 2823 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa- 81.67 93.81 73.33 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR- 15a-3p, hsa-let-7i-5p 2824 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 81.39 83.65 90.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p 2825 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa- 81.39 93.02 56.67 miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa- miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i- 5p 2826 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 81.39 92.70 73.33 miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa- miR-150-5p, hsa-miR-590-5p, hsa-miR-433-3p, hsa-miR- 29c-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-652- 5p 2827 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 81.39 81.98 73.33 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 744-5p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-629-5p 2828 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 81.39 92.38 73.33 miR-410-3p, hsa-miR-744-5p, hsa-miR-15a-5p, hsa-miR- 433-3p, hsa-miR-29c-5p, hsa-miR-629-5p, hsa-let-7i-5p 2829 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa- 81.39 94.05 70.00 miR-32-3p, hsa-miR-584-5p, hsa-miR-150-5p, hsa-miR- 29b-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-103a- 2-5p 2830 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 81.11 89.05 73.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p, hsa-let-7i-5p 2831 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 80.83 88.25 63.33 miR-584-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629- 5p, hsa-let-7i-5p 2832 hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 80.83 82.62 60.00 miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR- 664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR- 29b-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-miR-1296- 5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2833 hsa-miR-369-3p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa- 80.83 84.29 60.00 miR-29b-3p, hsa-miR-590-5p, hsa-miR-15a-5p, hsa-miR- 505-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-629- 5p, hsa-miR-103a-2-5p 2834 hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 79.44 87.22 63.33 miR-410-3p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-15a- 5p, hsa-miR-29c-5p, hsa-miR-148a-3p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p 2835 hsa-miR-34a-5p, hsa-miR-202-5p, hsa-miR-584-5p, hsa- 79.17 83.10 63.33 miR-664a-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 505-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545- 5p, hsa-miR-1296-5p, hsa-miR-652-5p 2836 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa- 78.89 87.94 43.33 miR-34a-5p, hsa-miR-32-3p, hsa-miR-744-5p, hsa-miR- 1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-433- 3p, hsa-miR-15a-3p 2837 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 78.61 86.59 63.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c- 5p, hsa-miR-629-5p, hsa-let-7i-5p 2838 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 78.61 93.33 70.00 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433- 3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p 2839 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 78.61 80.08 53.33 miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p 2840 hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa- 76.94 82.22 73.33 miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR- 15a-5p, hsa-miR-433-3p, hsa-miR-629-5p 2841 hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa- 76.67 88.41 63.33 miR-32-3p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-629- 5p 2842 hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa- 76.67 82.86 63.33 miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-433-3p, hsa-miR-629-5p 2843 hsa-miR-369-3p, hsa-miR-32-3p, hsa-miR-584-5p, hsa- 76.67 89.60 66.67 miR-744-5p, hsa-miR-150-5p, hsa-miR-505-5p, hsa-miR- 433-3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-miR- 103a-2-5p, hsa-let-7i-5p 2844 hsa-miR-369-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa- 76.67 86.19 63.33 miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR- 150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629- 5p 2845 combination 2591 + rs13335818 74.44 49.29 57.31 2846 combination 2592 + rs11647727 83.61 85.32 75.17 2847 combination 2595 + rs4297685 95.28 98.33 85.85 2848 combination 2596 + rs4297685 95.28 96.9 87.82 2849 combination 2597 + rs4297685 95.28 98.33 89.49 2850 combination 2598 + rs13335818 93.06 98.33 89.37 2851 combination 2598 + rs4293393 90.83 90.71 80 2852 combination 2599 + rs4297685 95.28 98.57 89.31 2853 combination 2599 + rs4293393 90.83 90.71 86.51 2854 combination 2600 + rs13335818 97.5 100 89.31 2855 combination 2600 + rs4293393 90.83 91.03 83.44 2856 combination 2601 + rs13335818 93.06 98.57 94.09 2857 combination 2601 + rs4293393 93.06 93.81 87.15 2858 combination 2602 + rs4297685 95.28 98.57 97.66 2859 combination 2603 + rs11647727 90.83 98.33 99.14 2860 combination 2604 + rs13335818 93.06 100 99.14 2861 combination 2605 + rs11647727 90.83 96.9 99.14 2862 combination 2617 + rs11647727 85.56 87.62 99.14 2863 combination 2818 + rs11647727 83.33 87.62 99.08 2864 combination 2819 + rs11647727 83.33 87.62 95.63 2865 combination 2591 + rs4293393 74.44 49.29 58.92

Through statistical analysis, the inventors demonstrated that UMOD variants are significantly associated with renal mass presence, malignancy, and aggressiveness in patients. The present data also revealed multiple potential biomarkers (miRNAs) of presence, stage, grade, and metastatic potential of RCC. The combined use of genetic and miRNAs data, together with clinical parameters, could have the unique potential to aid patient management in the setting of screening, diagnosis and therapeutic decision-making with respect to surgical and medical strategy and prognostic. The use of such combined biomarkers panel can lead to a tailored and personalized treatment to avoid unnecessary and associated wasteful costs. Then the present molecular tool can reduce the burden on public and private health care system.

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1. A method to determine if a renal mass present in a subject is a benign or a malignant renal mass comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 11 or Table 21 or is selected from the group consisting of: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p and wherein said combination is indicated in Table 16 or Table
 25. 2. The method according to claim 1 further comprising determining the genotype of UMOD SNPs rs71384446, rs9928757, rs11647727, rs28640218, rs7193058, rs76563024, rs11862974, rs13329952, rs7203642, rs7204342, and rs28688991 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs are selected from the group consisting of: rs7204775, rs4997081, rs12922822, rs12917707, rs9933330, rs13334589, rs13333226, rs28362063, rs4293393, rs35650857, rs34882080, rs13335818, rs28544423, rs9928003, rs12934320, rs34356953, rs34115067, rs60136849, rs9928936, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71149135, rs71377648, rs80159442, rs11342813, rs6497476, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs74842838, rs143657120, rs145915865, rs75645968, rs114333799, rs114112267, rs75459600, rs76625281, rs76236484, rs4500734, rs58351658, rs4490010, rs147846395, rs34857077, rs6497475, rs7204210, rs6497474, rs8060932, rs8062123, and rs4238595.
 3. A method to discriminate a subject affected by a low stage RCC from a subject affected by a high stage RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one is indicated in Table 13 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p and wherein said combination is indicated in Table 17 or Table
 26. 4. The method according to claim 3 further comprising determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs11647727, rs34356953, rs12934320, rs12934455, rs28640218, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs is selected from the group consisting of: rs12922822, rs9933330, rs13334589, rs34115067, rs9928936, rs71149134, rs7204775, rs71377648, rs9924088, rs9923990, rs9926225, rs111483946, rs112166439, rs113923200, rs554722277, rs111992415, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs8060932, rs8062123, rs4238595, rs7193058, rs34857077, rs6497475, rs6497474, rs181820305, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, and rs372456426.
 5. A method to discriminate a subject affected by a low grade RCC from a subject affected by a high grade RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 22 or is selected from the group consisting of: hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 18 or Table
 27. 6. The method according to claim 5 further comprising determining the genotype of UMOD SNP rs13333226 or of any other UMOD SNPs in linkage disequilibrium with rs13333226 (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNP is selected from the group consisting of: rs7204775, rs7203642, rs4293393, rs4997081, rs28688991, rs28640218, rs13329952, rs13335818, rs34115067, rs60136849, rs9928936, rs35650857, rs34882080, rs71149135, rs34356953, rs11862974, rs6497476, rs11342813, rs7204342, rs76563024, rs80159442, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs28362063, rs13334589, rs9933330, rs12922822, rs12917707, rs28544423, rs9928003, rs12934320, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71377648, rs9928757, and rs71384446.
 7. A method to determine the presence of clinical metastasis in a RCC patient comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 14 or is selected from the group consisting of: hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, and wherein the combination is indicated in Table
 19. 8. The method according to claim 7 further comprising determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs34356953, rs12934320, rs12934455, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs12922822, rs9933330, rs13334589, rs35650857, rs34882080, rs9928003, rs34115067, rs9928936, rs36060036, rs71149135, rs71149134, rs34262842, rs35830321, rs7204775, rs4997081, rs28640218, rs71377648, rs9924088, rs9923990, rs9926225, rs369494277, rs111483946, rs112166439, rs188045848, rs111904030, rs113923200, rs149786037, rs554722277, rs113452476, rs111992415, rs377257136, rs114997829, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs372456426, rs6497475, rs34857077, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, rs181820305, rs4238595, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs8060932, and rs8062123.
 9. A method for predicting a prognosis of RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 13 or Table 14 or Table 22 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, and hsa-miR-15a-5p, hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 17 or Table 18 or Table 19 or Table 26 or Table
 27. 10. The method according to claim 9 further comprising determining the genotype of UMOD SNPs rs11647727, rs12917707, rs12934320, rs12934455, rs13329952, rs13333226, rs13335818, rs28362063, rs28544423, rs28640218, rs28688991, rs34356953, rs4293393, rs60136849, rs71384446, rs7203642, and rs9928757 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs111266260, rs111483946, rs111904030, rs111992415, rs112166439, rs11342813, rs113452476, rs113923200, rs113957052, rs114997829, rs116563128, rs117774819, rs118059635, rs11862974, rs12102292, rs12922822, rs13334589, rs138755971, rs145279202, rs147946789, rs149233634, rs149786037, rs150044343, rs150052437, rs181711435, rs181820305, rs182188833, rs182605229, rs182744661, rs183590048, rs184483102, rs185128245, rs185578691, rs185630961, rs186260541, rs187620954, rs188045848, rs189908977, rs190450490, rs191065984, rs191171015, rs192180621, rs192280820, rs34115067, rs34262842, rs34857077, rs34882080, rs35650857, rs35830321, rs36060036, rs369494277, rs372456426, rs377257136, rs4238595, rs4997081, rs528859496, rs544951514, rs554722277, rs55808501, rs58768874, rs59027126, rs6497474, rs6497475, rs6497476, rs71149134, rs71149135, rs71377648, rs7193058, rs7204342, rs7204775, rs74011921, rs74011925, rs75864273, rs76563024, rs77225526, rs77875418, rs78052469, rs79245268, rs80142672, rs80159442, rs8060932, rs8062123, rs9923990, rs9924088, rs9926225, rs9928003, rs9928936, rs9933330, and rs9937393.
 11. A method to predict the presence of a renal mass in a subject comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 10 or Table 20 or is selected from the group consisting of: hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-28-3p, hsa-miR-15b, 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, and hsa-miR-494-3p and wherein the combination is indicated in Table 15 or Table
 24. 12. The method according to claim 11 wherein the subject is affected by obesity, autosomal polycystic kidney disease, multicystic kidney disease, hypertension or diabetes or wherein the subject is a smoker or has a family history of kidney cancer.
 13. The method according to claim 1 further comprising measuring the level of uromodulin in a biological sample of the subject and comparing said measured level to a reference level, preferably the biological sample is selected from the group consisting of: plasma, serum and urine sample.
 14. The method according to claim 1 further comprising the analysis of a phenotypic characteristic, preferably selected from the group consisting of: clinical parameters, such as age at diagnosis/treatment, comorbidity index and specific comorbidities or history of previous renal or non-renal cancer; radiological parameters, such as clinical size defined as clinical diameter at axial imaging, tumor volume, clinical tumor stage, clinical nodal stage, PADUA score, RENAL score, ABC score or other nephrometric scores; biohumoral parameters, such as hemoglobin, platelets, creatinine, urea, blood electrolytes, total protein serum level and electrophoresis, measured and estimated glomerular filtration rate, proteinuria and urine tests.
 15. The method according to claim 1 wherein the biological sample is selected from: blood, blood cells, serum, plasma, urine, saliva, sputum, tears, kidney tissue.
 16. A kit comprising (a) means to quantify at least one miRNA that is indicated in Table 11 or Table 21 or is selected from the group consisting of: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p and (b) control means.
 17. The kit according to claim 16, further comprising means to determine at least one UMOD genotype.
 18. The kit according to claim 16, wherein the kit comprises an array.
 19. A method according to claim 1, further comprising treating the subject surgically via nephron sparing surgery or radical nephrectomy.
 20. A method according to claim 1, further comprising surgically removing renal tumor mass.
 21. A method according to claim 11, further comprising determining the genotype of UMOD SNPs rs11647727 and rs7193058 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs28640218, rs34857077, rs6497475, rs6497474, and rs7204210. 